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High-throughput sequencing technologies have led to explosive growth of genomic databases; one of which will soon reach hundreds of terabytes. For many applications we want to build and store indexes of these databases but constructing such…

Data Structures and Algorithms · Computer Science 2018-11-19 Christina Boucher , Travis Gagie , Alan Kuhnle , Ben Langmead , Giovanni Manzini , Taher Mun

When building Burrows-Wheeler Transforms (BWTs) of truly huge datasets, prefix-free parsing (PFP) can use an unreasonable amount of memory. In this paper we show how if a dataset can be broken down into small datasets that are not very…

Data Structures and Algorithms · Computer Science 2025-06-09 Diego Diaz-Dominguez , Travis Gagie , Veronica Guerrini , Ben Langmead , Zsuzsanna Liptak , Giovanni Manzini , Francesco Masillo , Vikram Shivakumar

We propose a new technique for creating a space-efficient index for large repetitive text collections, such as pangenomic databases containing sequences of many individuals from the same species. We combine two recent techniques from this…

Data Structures and Algorithms · Computer Science 2023-08-28 Adrián Goga , Andrej Baláž

The Positional Burrows--Wheeler Transform (PBWT) is a data structure designed for efficiently representing and querying large collections of sequences, such as haplotype panels in genomics. Forward and backward stepping operations --…

Data Structures and Algorithms · Computer Science 2026-02-17 Paola Bonizzoni , Davide Cozzi , Younan Gao

FM-indexes are a crucial data structure in DNA alignment, for example, but searching with them usually takes at least one random access per character in the query pattern. Ferragina and Fischer observed in 2007 that word-based indexes often…

Data Structures and Algorithms · Computer Science 2023-05-11 Aaron Hong , Marco Oliva , Dominik Köppl , Hideo Bannai , Christina Boucher , Travis Gagie

Indexing of very large collections of strings such as those produced by the widespread sequencing technologies, heavily relies on multi-string generalizations of the Burrows-Wheeler Transform (BWT), and for this problem various in-memory…

Data Structures and Algorithms · Computer Science 2016-07-29 Paola Bonizzoni , Gianluca Della Vedova , Serena Nicosia , Marco Previtali , Raffaella Rizzi

We show how to build several data structures of central importance to string processing, taking as input the Burrows-Wheeler transform (BWT) and using small extra working space. Let $n$ be the text length and $\sigma$ be the alphabet size.…

Data Structures and Algorithms · Computer Science 2019-08-14 Nicola Prezza , Giovanna Rosone

Indexing very large collections of strings, such as those produced by the widespread next generation sequencing technologies, heavily relies on multistring generalization of the Burrows-Wheeler Transform (BWT): large requirements of…

Data Structures and Algorithms · Computer Science 2020-12-07 Paola Bonizzoni , Gianluca Della Vedova , Yuri Pirola , Marco Previtali , Raffaella Rizzi

We show that the Longest Common Prefix Array of a text collection of total size n on alphabet [1, {\sigma}] can be computed from the Burrows-Wheeler transformed collection in O(n log {\sigma}) time using o(n log {\sigma}) bits of working…

Data Structures and Algorithms · Computer Science 2019-01-23 Nicola Prezza , Giovanna Rosone

Mantaci et al. [TCS 2007] defined the eBWT to extend the definition of the BWT to a collection of strings, however, since this introduction, it has been used more generally to describe any BWT of a collection of strings and the fundamental…

Data Structures and Algorithms · Computer Science 2021-06-22 Christina Boucher , Davide Cenzato , Zsuzsanna Lipták , Massimiliano Rossi , Marinella Sciortino

We present a new semi-external algorithm that builds the Burrows--Wheeler transform variant of Bauer et al. (a.k.a., BCR BWT) in linear expected time. Our method uses compression techniques to reduce computational costs when the input is…

Data Structures and Algorithms · Computer Science 2023-08-15 Diego Díaz-Domínguez , Gonzalo Navarro

The positional Burrows-Wheeler Transform (PBWT) is commonly used to store haplotype panels compactly in such a way that, given a query haplotype, we can quickly find the set maximal exact matches (SMEMs) between the query and the haplotypes…

Data Structures and Algorithms · Computer Science 2026-05-26 Travis Gagie

Motivation The Burrows-Wheeler transform (BWT) is the foundation of many algorithms for compression and indexing of text data, but the cost of computing the BWT of very large string collections has prevented these techniques from being…

Data Structures and Algorithms · Computer Science 2015-03-20 Anthony J. Cox , Markus J. Bauer , Tobias Jakobi , Giovanna Rosone

Given a text, a query $\mathsf{rank}(q, c)$ counts the number of occurrences of character $c$ among the first $q$ characters of the text. Space-efficient methods to answer these rank queries form an important building block in many succinct…

Data Structures and Algorithms · Computer Science 2026-04-02 R. Groot Koerkamp

The suffix array is an efficient data structure for in-memory pattern search. Suffix arrays can also be used for external-memory pattern search, via two-level structures that use an internal index to identify the correct block of suffix…

Data Structures and Algorithms · Computer Science 2013-03-27 Simon Gog , Alistair Moffat , J. Shane Culpepper , Andrew Turpin , Anthony Wirth

While short read aligners, which predominantly use the FM-index, are able to easily index one or a few human genomes, they do not scale well to indexing databases containing thousands of genomes. To understand why, it helps to examine the…

Data Structures and Algorithms · Computer Science 2018-11-19 Alan Kuhnle , Taher Mun , Christina Boucher , Travis Gagie , Ben Langmead , Giovanni Manzini

We propose algorithms that, given the input string of length $n$ over integer alphabet of size $\sigma$, construct the Burrows-Wheeler transform (BWT), the permuted longest-common-prefix (PLCP) array, and the LZ77 parsing in…

Data Structures and Algorithms · Computer Science 2020-12-09 Dominik Kempa

A recent paradigm shift in bioinformatics from a single reference genome to a pangenome brought with it several graph structures. These graph structures must implement operations, such as efficient construction from multiple genomes and…

Data Structures and Algorithms · Computer Science 2023-06-27 Andrej Baláž , Alessia Petescia

Recently, Cenzato et al.\ proposed a new text index, called the \emph{suffixient array}, which is a subset of the suffix array and supports locating a single pattern occurrence or finding its maximal exact matches (MEMs), assuming random…

Data Structures and Algorithms · Computer Science 2026-05-07 Paola Bonizzoni , Younan Gao , Brian Riccardi

The longest common prefix array is a very advantageous data structure that, combined with the suffix array and the Burrows-Wheeler transform, allows to efficiently compute some combinatorial properties of a string useful in several…

Data Structures and Algorithms · Computer Science 2016-05-16 Anthony J. Cox , Fabio Garofalo , Giovanna Rosone , Marinella Sciortino
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