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To facilitate rational molecular and materials design, this research proposes an integrated computational framework that combines stochastic simulation, ab initio quantum chemistry, and molecular docking. The suggested workflow allows…

Materials Science · Physics 2026-01-08 Md Rakibul Karim Akanda , Michael P. Richard

Owing to the computational complexity of electronic structure algorithms running on classical digital computers, the range of molecular systems amenable to simulation remains tightly circumscribed even after many decades of work. Quantum…

Quantum Physics · Physics 2022-05-18 Alexis Ralli , Michael I. Williams , Peter V. Coveney

Over the past three decades, countless embodied yet virtual agents have freely evolved inside computer simulations, but vanishingly few were realized as physical robots. This is because evolution was conducted at a level of abstraction that…

Robotics · Computer Science 2026-03-17 Zihan Guo , Muhan Li , Shuzhe Zhang , Sam Kriegman

This paper proposes a software repository model together with associated tooling and consists of several complex, open-source GUI driven applications ready to be used in empirical software research. We start by providing the rationale for…

Software Engineering · Computer Science 2017-02-28 Arthur-Jozsef Molnar

As large language models (LLMs) continue to improve in reasoning and decision-making, there is a growing need for realistic and interactive environments where their abilities can be rigorously evaluated. We present VirtualEnv, a…

Artificial Intelligence · Computer Science 2026-02-10 Kabir Swain , Sijie Han , Ayush Raina , Jin Zhang , Shuang Li , Michael Stopa , Antonio Torralba

The rapid evolution of embedded systems, along with the growing variety and complexity of AI algorithms, necessitates a powerful hardware/software co-design methodology based on virtual prototyping technologies. The market offers a diverse…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-20 Tim Kraus , Axel Sauer , Ingo Feldner

A consistent theme in software experimentation at Microsoft has been solving problems of experimentation at scale for a diverse set of products. Running experiments at scale (i.e., many experiments on many users) has become state of the art…

Applications · Statistics 2019-12-03 Craig Boucher , Ulf Knoblich , Daniel Miller , Sasha Patotski , Amin Saied , Venky Venkateshaiah

The miniaturization and integration of electronic circuitry has not only made the enormous increase in performance of semiconductor devices possible but also spawned a myriad of new products and applications ranging from a cellular phone to…

Fluid Dynamics · Physics 2011-03-16 A. Rathgeber , C. Strobl , H. -J. Kutschera , A. Wixforth

This paper proposes a novel approach to scaling distributed collaboration in mixed reality by virtualizing collaborative tasks as independent, installable environments. By mapping group activities into dedicated virtual spaces that adapt to…

Human-Computer Interaction · Computer Science 2025-04-07 Euijun Jung , Youngki Lee

Performing a computer experiment can be viewed as observing a mapping between the model parameters and the corresponding model outputs predicted by the computer model. In view of this, experimental design for computer experiments can be…

Computation · Statistics 2017-12-29 Chang-Han Rhee , Enlu Zhou , Peng Qiu

Heraklit is an ongoing research program and development project aimed at creating an infrastructure for modeling large-scale, computer-integrated systems. We discuss the key requirements for such models (hierarchies, user view,…

Software Engineering · Computer Science 2022-05-23 Peter Fettke , Wolfgang Reisig

In the past twelve months, our team has had to move rapidly from conducting most of our user experiments in a laboratory setting, to running experiments in the wild away from the laboratory and without direct synchronous oversight from an…

Human-Computer Interaction · Computer Science 2021-04-13 Anthony Steed , Daniel Archer , Ben Congdon , Sebastian Friston , David Swapp , Felix J. Thiel

At present moment, there is a great interest in development of information systems operating in cloud infrastructures. Generally, many of tasks remain unresolved such as tasks of optimization of large databases in a hybrid cloud…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-09-17 Evgeniy Pluzhnik , Evgeny Nikulchev , Simon Payain

Optimal use of computing resources requires extensive coding, tuning and benchmarking. To boost developer productivity in these time consuming tasks, we introduce the Experimental Linear Algebra Performance Studies framework (ELAPS), a…

Performance · Computer Science 2015-05-01 Elmar Peise , Paolo Bientinesi

As quantum computing evolves from theoretical promise to practical deployment, the demand for robust, portable, and scalable tools for quantum software experimentation is growing. This paper introduces Quantum Executor, a backend-agnostic…

Quantum Physics · Physics 2025-07-11 Giuseppe Bisicchia , Alessandro Bocci , Antonio Brogi

The vulnerability of cyber-physical systems to cyber attack is well known, and the requirement to build cyber resilience into these systems has been firmly established. The key challenge this paper addresses is that maturing this discipline…

Cryptography and Security · Computer Science 2023-02-17 Jason E. Ellis , Travis W. Parker , Joachim Vandekerckhove , Brian J. Murphy , Sidney Smith , Alexander Kott , Michael J. Weisman

Embodied AI systems, comprising AI models and physical plants, are increasingly prevalent across various applications. Due to the rarity of system failures, ensuring their safety in complex operating environments remains a major challenge,…

In context of highly complex energy system experiments, sensitivity analysis is gaining more and more importance to investigate the effects changing parameterization has on the outcome. Thus, it is crucial how to design an experiment to…

Computational Engineering, Finance, and Science · Computer Science 2024-10-23 Jan Sören Schwarz , Leonard Enrique Ramos Perez , Minh Cong Pham , Kai Heussen , Quoc Tuan Tran

Rigorous and reproducible evaluation is critical for assessing the state of the art and for guiding scientific advances in Artificial Intelligence. Evaluation is challenging in practice due to several reasons, including benchmark…

Computer simulations have become a very powerful tool for scientific research. Given the vast complexity that comes with many open scientific questions, a purely analytical or experimental approach is often not viable. For example,…

Neural and Evolutionary Computing · Computer Science 2016-07-12 Roman Bauer , Lukas Breitwieser , Alberto Di Meglio , Leonard Johard , Marcus Kaiser , Marco Manca , Manuel Mazzara , Max Talanov