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To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy treatment planning that combines deep-learning(DL) aperture predictions and forward-planning algorithms. We designed an algorithm to automate the…

Dose prediction is an area of ongoing research that facilitates radiotherapy planning. Most commercial models utilise imaging data and intense computing resources. This study aimed to predict the dose-volume of rectum and bladder from…

Deep learning models (DLMs) can achieve state-of-the-art performance in histopathology image segmentation and classification, but have limited deployment potential in real-world clinical settings. Uncertainty estimates of DLMs can increase…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Audrey Xie , Elhoucine Elfatimi , Sambuddha Ghosal , Pratik Shah

Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…

Quantitative Methods · Quantitative Biology 2024-09-19 Qingqing Wang , Chang Chang

Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation. The dose conformity of this treatment modality may be further improved if narrower proton…

Conventional beam orientation optimization (BOO) algorithms for IMRT assume that the same set of beam angles is used for all treatment fractions. In this paper we present a BOO formulation based on group sparsity that simultaneously…

Medical Physics · Physics 2018-03-14 Daniel O'Connor , Dan Nguyen , Dan Ruan , Victoria Yu , Ke Sheng

We propose the BayesDose-Framework, a Bayesian approach for fast and accurate dose prediction in proton therapy. Our framework is based on a previously published deterministic LSTM model and is trained and evaluated on simulated beamlet…

Medical Physics · Physics 2023-07-04 Luke Voss , Ahmad Neishabouri , Tim Ortkamp , Andrea Mairani , Niklas Wahl

This study focuses on comparing deep learning methods for the segmentation and quantification of uncertainty in prostate segmentation from MRI images. The aim is to improve the workflow of prostate cancer detection and diagnosis. Seven…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Pablo Cesar Quihui-Rubio , Daniel Flores-Araiza , Gilberto Ochoa-Ruiz , Miguel Gonzalez-Mendoza , Christian Mata

Dose volume histograms are a useful tool in state-of-the-art radiotherapy planning, and it is essential to be aware of their limitations. Dose distributions computed by treatment planning systems are affected by several sources of…

Medical Physics · Physics 2007-06-13 Francisco Cutanda-Henriquez , Silvia Vargas-Castrillon

Automatic classification of Diabetic Retinopathy (DR) can assist ophthalmologists in devising personalized treatment plans, making it a critical component of clinical practice. However, imbalanced data distribution in the dataset becomes a…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Abdul Hannan , Zahid Mahmood , Rizwan Qureshi , Hazrat Ali

Deep learning (DL) has successfully automated dose distribution prediction in radiotherapy planning, enhancing both efficiency and quality. However, existing methods suffer from the over-smoothing problem for their commonly used L1 or L2…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Zhenghao Feng , Lu Wen , Jianghong Xiao , Yuanyuan Xu , Xi Wu , Jiliu Zhou , Xingchen Peng , Yan Wang

Volumetric Modulated Arc Therapy (VMAT) revolutionizes cancer treatment by precisely delivering radiation while sparing healthy tissues. Fluence maps generation, crucial in VMAT planning, traditionally involves complex and iterative, and…

Image and Video Processing · Electrical Eng. & Systems 2025-02-06 Simon Arberet , Florin C. Ghesu , Riqiang Gao , Martin Kraus , Jonathan Sackett , Esa Kuusela , Ali Kamen

Purpose: To develop a deep network architecture that would achieve fully automated radiologist-level segmentation of cancers at breast MRI. Materials and Methods: In this retrospective study, 38229 examinations (composed of 64063 individual…

Purpose: To develop a model to generate volumetric dose distribution from two isodose surfaces (iso-surfaces), and to interactively tune dose distribution by iso-surface dragging. Methods: We model volumetric dose distribution as analytical…

Medical Physics · Physics 2022-03-01 Lin Ma , Mingli Chen , Xuejun Gu , Weiguo Lu

Cancer drug response prediction (DRP) models present a promising approach towards precision oncology, tailoring treatments to individual patient profiles. While deep learning (DL) methods have shown great potential in this area, models that…

Stereotactic body radiotherapy (SBRT) is characterized by delivering a high amount of dose in a short period of time. In SBRT the dose is delivered using open fields (e.g., beam's-eye-view) known as "apertures". Mathematical methods can be…

Medical Physics · Physics 2015-06-15 Hamed Yarmand , David Craft

Huge overhead of beam training imposes a significant challenge in millimeter-wave (mmWave) wireless communications. To address this issue, in this paper, we propose a wide beam based training approach to calibrate the narrow beam direction…

Signal Processing · Electrical Eng. & Systems 2021-07-21 Ke Ma , Dongxuan He , Hancun Sun , Zhaocheng Wang , Sheng Chen

Cancer claims millions of lives yearly worldwide. While many therapies have been made available in recent years, by in large cancer remains unsolved. Exploiting computational predictive models to study and treat cancer holds great promise…

Quantitative Methods · Quantitative Biology 2022-11-22 Alexander Partin , Thomas S. Brettin , Yitan Zhu , Oleksandr Narykov , Austin Clyde , Jamie Overbeek , Rick L. Stevens

The emergence of multi-parametric magnetic resonance imaging (mpMRI) has had a profound impact on the diagnosis of prostate cancers (PCa), which is the most prevalent malignancy in males in the western world, enabling a better selection of…

Currently, deep learning (DL) has achieved the automatic prediction of dose distribution in radiotherapy planning, enhancing its efficiency and quality. However, existing methods suffer from the over-smoothing problem for their commonly…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Zhenghao Feng , Lu Wen , Peng Wang , Binyu Yan , Xi Wu , Jiliu Zhou , Yan Wang