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In the present article the diffusion equation is used to model the spatio-temporal dynamics of a tumor, taking into account the heterogeneous of the medium. This approach makes it possible to take into account the complex geometric shape of…

Biological Physics · Physics 2023-02-07 Maxim V. Polyakov , Valeria V. Ten

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein

We study a time-fractional Fisher-KPP equation involving a Riemann-Liouville fractional derivative acting on the diffusion term, as derived by Angstmann and Henry (Entropy, 22:1035, 2020). The model captures memory effects in diffusive…

Analysis of PDEs · Mathematics 2025-11-10 Marvin Fritz , Nikos I. Kavallaris

In this work, we investigate a fractional-order tumor growth model aimed at capturing memory effects and nonlocal temporal dynamics inherent to tumor evolution. The model is formulated using Caputo fractional derivatives and incorporates…

Medical Physics · Physics 2026-03-17 Karen Escutia , Carlos Islas , Pablo Padilla

We investigate the evolution of tumor growth relying on a nonlinear model of partial differential equations which incorporates mechanical laws for tissue compression combined with rules for nutrients availability and drug application.…

Numerical Analysis · Mathematics 2016-02-23 Konstantina Trivisa , Franziska Weber

In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour…

Tissues and Organs · Quantitative Biology 2019-05-15 Sounak Sadhukhan , S. K. Basu

We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…

Analysis of PDEs · Mathematics 2015-06-22 Donatella Donatelli , Konstantina Trivisa

Many physical phenomena occur on domains that grow in time. When the timescales of the phenomena and domain growth are comparable, models must include the dynamics of the domain. A widespread intrinsically slow transport process is…

Statistical Mechanics · Physics 2017-11-01 C. N. Angstmann , B. I. Henry , A. V. McGann

We consider a biphasic continuum model for avascular tumour growth in two spatial dimensions, in which a cell phase and a fluid phase follow conservation of mass and momentum. A limiting nutrient that follows a diffusion process controls…

Numerical Analysis · Mathematics 2020-10-21 Jerome Droniou , Jennifer A. Flegg , Gopikrishnan C. Remesan

In this work, we develop a structure-preserving numerical scheme for a Cahn-Hilliard-Darcy model that describes tumor growth in a fluid-saturated porous medium. First, we derive a physically consistent model from the general framework…

Numerical Analysis · Mathematics 2026-05-22 Daniel Acosta-Soba , Francisco Guillén-González , J. Rafael Rodríguez-Galván

In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalization of a phase field…

Analysis of PDEs · Mathematics 2019-06-27 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

We consider the initial/boundary value problem for a diffusion equation involving multiple time-fractional derivatives on a bounded convex polyhedral domain. We analyze a space semidiscrete scheme based on the standard Galerkin finite…

Numerical Analysis · Mathematics 2015-06-18 Bangti Jin , Raytcho Lazarov , Yikan Liu , Zhi Zhou

The work presents a study of the non-linear mathematical model of tumor growth, proposed by Kolev and Zubik-Kowal (2011). The model is described by a system composed of four partial differential equations that represent the evolution of the…

Tissues and Organs · Quantitative Biology 2025-06-02 Jesika Maganin , Neyva Maria Lopes Romeiro , Eliandro Rodrigues Cirilo , Paulo Laerte Natti

In this paper, a free boundary problem modelling the growth of tumor is considered. The model includes two reaction-diffusion equations modelling the diffusion of nutrient and drug in the tumor and three hyperbolic equations describing the…

Numerical Analysis · Mathematics 2020-01-29 Sakine Esmaili , F. Nasresfahani , M. R. Eslahchi

We introduce a new diffuse interface model for tumour growth in the presence of a nutrient, in which we take into account mechanical effects and reversible tissue damage. The highly nonlinear PDEs system mainly consists of a Cahn-Hilliard…

Analysis of PDEs · Mathematics 2025-10-09 Giulia Cavalleri

We consider a one--spatial dimensional tumour growth model [2, 3, 4] that consists of three dependent variables of space and time: volume fraction of tumour cells, velocity of tumour cells, and nutrient concentration. The model variables…

Numerical Analysis · Mathematics 2020-07-01 Jerome Droniou , Neela Nataraj , Gopikrishnan Chirappurathu Remesan

In this paper, we propose a fractional differential equation of order one-half, to model the evolution through time of the dynamics of accumulation and elimination of the contaminant in human organism with a deficient immune system, during…

Methodology · Statistics 2022-07-28 Komla Elom Adedje , Diakarya Barro

In this paper we present a study of local dynamics of the growth of cancer tumor and healthy cells considering the presence of nutrients in the system. We also analyze the evolution of system if we take indirectly into account the level of…

Biological Physics · Physics 2019-01-29 Cristian C. Pérez Águila , Maura Cárdenas G. , J. Fernando Rojas

Mechanical models for tumor growth have been used extensively in recent years for the analysis of medical observations and for the prediction of cancer evolution based on imaging analysis. This work deals with the numerical approximation of…

Numerical Analysis · Mathematics 2015-04-24 Konstantina Trivisa , Franziska Weber

In this note we analyse the propagation of a small density perturbation in a one-dimensional compressible fluid by means of fractional calculus modelling, replacing thus the ordinary time derivative with the Caputo fractional derivative in…

Analysis of PDEs · Mathematics 2014-03-06 Roberto Garra , Federico Polito
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