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Mapping the brain imaging data to networks, where each node represents a specific area of the brain, has enabled an objective graph-theoretic analysis of human connectome. However, the latent structure on higher-order connections remains…

Neurons and Cognition · Quantitative Biology 2019-04-09 Bosiljka Tadic , Miroslav Andjelkovic , Roderick Melnik

Brain connectomics is still largely dominated by pairwise-based models, such as graphs, which cannot represent circulatory or higher-order functional interactions. In this paper, we propose a multimodal framework based on Topological Signal…

Neurons and Cognition · Quantitative Biology 2026-04-01 Breno C. Bispo , Stefania Sardellitti , Juliano B. Lima , Fernando A. N. Santos

The large-scale structural ingredients of the brain and neural connectomes have been identified in recent years. These are, similar to the features found in many other real networks: the arrangement of brain regions into modules and the…

Neurons and Cognition · Quantitative Biology 2018-11-01 Gorka Zamora-López , Yuhan Chen , Gustavo Deco , Morten L. Kringelbach , Changsong Zhou

Brain imaging data mapping onto human connectome networks enables the investigation of global brain dynamics, where the brain hubs play an essential role in transferring activity between different brain parts. At this scale, the…

Pattern Formation and Solitons · Physics 2025-07-11 Bosiljka Tadic , Marija Mitrovic Dankulov , Roderick Melnik

Investigations of the human connectome have elucidated core features of adult structural networks, particularly the crucial role of hub-regions. However, little is known regarding network organisation of the healthy elderly connectome, a…

Neurons and Cognition · Quantitative Biology 2015-12-15 Alistair Perry , Wei Wen , Anton Lord , Anbupalam Thalamuthu , Perminder Sachdev , Michael Breakspear

To understand collective network behavior in the complex human brain, pairwise correlation networks alone are insufficient for capturing the high-order interactions that extend beyond pairwise interactions and play a crucial role in brain…

Neurons and Cognition · Quantitative Biology 2025-07-01 Qiang Li , Jingyu Liu , Vince D. Calhoun

Simplicial complexes capture the underlying network topology and geometry of complex systems ranging from the brain to social networks. Here we show that algebraic topology is a fundamental tool to capture the higher-order dynamics of…

Disordered Systems and Neural Networks · Physics 2021-07-12 Reza Ghorbanchian , Juan G. Restrepo , Joaquín J. Torres , Ginestra Bianconi

Encoding brain regions and their connections as a network of nodes and edges captures many of the possible paths along which information can be transmitted as humans process and perform complex behaviors. Because cognitive processes involve…

Neurons and Cognition · Quantitative Biology 2016-12-21 Ann Sizemore , Chad Giusti , Ari Kahn , Richard F. Betzel , Danielle S. Bassett

Higher-order networks are gaining significant scientific attention due to their ability to encode the many-body interactions present in complex systems. However, higher-order networks have the limitation that they only capture many-body…

Adaptation and Self-Organizing Systems · Physics 2023-12-20 Sanjukta Krishnagopal , Ginestra Bianconi

Understanding how cortex, subcortex and cerebellum integrate is a major challenge for neuroscience, however, studies of the brain's structural connectivity have mostly focused on cortico-cortical links. Here, we used diffusion imaging to…

Neurons and Cognition · Quantitative Biology 2025-10-21 Julian Schulte , Mario Senden , Gustavo Deco , Xenia Kobeleva , Gorka Zamora-López

In recent years numerous attempts to understand the human brain were undertaken from a network point of view. A network framework takes into account the relationships between the different parts of the system and enables to examine how…

Neurons and Cognition · Quantitative Biology 2018-03-13 Nir Lahav , Baruch Ksherim , Eti Ben-Simon , Adi Maron-Katz , Reuven Cohen , Shlomo Havlin

Human brain structural networks contain sets of centrally embedded hub regions that enable efficient information communication. However, it remains largely unknown about categories of structural brain hubs and their microstructural,…

Neurons and Cognition · Quantitative Biology 2016-09-13 Xindi Wang , Qixiang Lin , Mingrui Xia , Yong He

Simplicial complexes constitute the underlying topology of interacting complex systems including among the others brain and social interaction networks. They are generalized network structures that allow to go beyond the framework of…

Disordered Systems and Neural Networks · Physics 2020-06-02 Joaquín J. Torres , Ginestra Bianconi

The human brain is a complex system defined by multi-way, higher-order interactions invisible to traditional pairwise network models. Although a diverse array of analytical methods has been developed to address this shortcoming, the field…

Quantitative Methods · Quantitative Biology 2025-11-11 Mohamma Reza Salehi , Ali BashirGonbadi , Hamid Soltanian-Zadeh

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

Hypergraphs and simplical complexes both capture the higher-order interactions of complex systems, ranging from higher-order collaboration networks to brain networks. One open problem in the field is what should drive the choice of the…

Physics and Society · Physics 2022-09-28 Federica Baccini , Filippo Geraci , Ginestra Bianconi

The underlying anatomical structure is fundamental to the study of brain networks, but the role of brainstem from a structural perspective is not very well understood. We conduct a computational and graph-theoretical study of the human…

Neurons and Cognition · Quantitative Biology 2023-04-26 Salma Salhi , Youssef Kora , Gisu Ham , Hadi Zadeh Haghighi , Christoph Simon

Higher-order networks are able to capture the many-body interactions present in complex systems and to unveil new fundamental phenomena revealing the rich interplay between topology, geometry, and dynamics. Simplicial complexes are…

Disordered Systems and Neural Networks · Physics 2024-10-08 Runyue Wang , Riccardo Muolo , Timoteo Carletti , Ginestra Bianconi

The architecture of the human connectome supports efficient communication protocols relying either on distances between brain regions or on the intensities of connections. However, none of these protocols combines information about the two…

Neurons and Cognition · Quantitative Biology 2024-10-07 Laia Barjuan , Jordi Soriano , M. Ángeles Serrano

Complex systems in the real world can be modeled as a network of connected components. The human brain, as a network of neurons among which the interactions cause perception, is a complex network. Synchronization is a dynamical phenomenon…

Biological Physics · Physics 2019-04-30 Arefeh Mazarei , Mohammad Amirian Matlob , Gholamhossein Riazi , Yousef Jamali
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