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Intrinsic transcriptional noise induced by operator fluctuations is investigated with a simple spin like stochastic model. The effects of transcriptional fluctuations in protein synthesis is probed by coupling transcription and translation…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Guilherme da C. P. Innocentini , Jose E. M. Hornos

This paper is the first part of a two-part series in which we present results from an experimental demonstration of frequency regulation in a commercial building test facility. In Part I, we introduce the test facility and develop relevant…

Optimization and Control · Mathematics 2016-05-20 Evangelos Vrettos , Emre C. Kara , Jason MacDonald , Göran Andersson , Duncan S. Callaway

Recently, stochastic resonance was obtained numerically in an underdamped periodic potential system driven by a periodic force and a Gaussian white noise. In that numerical work, the occurrence of stochastic resonance was explained in terms…

Chaotic Dynamics · Physics 2018-12-21 Ivan Skhem Sawkmie , Mangal C. Mahato

The rapid advancement of neuroscience and machine learning has established data-driven stochastic dynamical system modeling as a powerful tool for understanding and controlling high-dimensional, spatio-temporal processes. We introduce the…

Dynamical Systems · Mathematics 2025-05-15 Jiani Cheng , Ting Gao , Jinqiao Duan

Actuating the acoustic resonance modes of a microfluidic device containing suspended particles (e.g., cells) allows for the manipulation of their individual positions. In this work, we investigate how the number of resonance modes $M$…

Applied Physics · Physics 2025-10-08 Guilherme Perticarari , Dongjun Wu , Thierry Baasch

We show that current fluctuations in a stochastic pump can be robustly mapped to fluctuations in a corresponding time-independent nonequilibrium steady state. We thus refine a recently proposed mapping so that it ensures equivalence of not…

Statistical Mechanics · Physics 2017-03-22 Grant M. Rotskoff

We study the surface fluctuations of a tissue with a dynamics dictated by cell-rearrangement, cell-division, and cell-death processes. Surface fluctuations are calculated in the homeostatic state, where cell division and cell death…

Biological Physics · Physics 2015-12-22 Thomas Risler , Aurélien Peilloux , Jacques Prost

A binary fluid mixture in contact with lateral particle reservoirs is considered. By imposing different particle concentrations in these reservoirs, the system can be maintained under controlled non-equilibrium conditions. Previous…

Statistical Mechanics · Physics 2026-04-01 O. Politano , Alejandro L. Garcia , F. Baras , M. Malek Mansour

We propose an adaptive optimisation approach for tuning stochastic model predictive control (MPC) hyper-parameters while jointly estimating probability distributions of the transition model parameters based on performance rewards. In…

Robotics · Computer Science 2022-06-02 Rel Guzman , Rafael Oliveira , Fabio Ramos

Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as…

Biological Physics · Physics 2018-05-02 F. Gnesotto , F. Mura , J. Gladrow , C. P. Broedersz

Stochastic hydrodynamics provides a dynamical framework for the evolution of fluctuations in heavy-ion collisions, but poses significant challenges in numerical simulations. We present an algorithm for the simulation of non-relativistic…

Nuclear Theory · Physics 2026-02-03 Mattis Harhoff , Sören Schlichting , Lorenz von Smekal

The proper sorting of membrane components by regulated exchange between cellular organelles is crucial to intra-cellular organisation. This process relies on the budding and fusion of transport vesicles, and should be strongly influenced by…

Biological Physics · Physics 2018-02-07 Quentin Vagne , Pierre Sens

Model-based prediction of stochastic noise in biomolecular reactions often resorts to approximation with unknown precision. As a result, unexpected stochastic fluctuation causes a headache for the designers of biomolecular circuits. This…

Molecular Networks · Quantitative Biology 2018-08-07 Yuta Sakurai , Yutaka Hori

In this paper we propose a framework towards achieving two intertwined objectives: (i) equipping reinforcement learning with active exploration and deliberate information gathering, such that it regulates state and parameter uncertainties…

Machine Learning · Computer Science 2024-09-10 Mohammad S. Ramadan , Mahmoud A. Hayajnh , Michael T. Tolley , Kyriakos G. Vamvoudakis

Stochastic resonance is a general phenomenon usually observed in one-dimensional, amplitude modulated, bistable systems.We show experimentally the emergence of phase stochastic resonance in the bidimensional response of a forced…

Hybrid multiscale modelling has emerged as a useful framework for modelling complex biological phenomena. However, when accounting for stochasticity in the internal dynamics of agents, these models frequently become computationally…

Quantitative Methods · Quantitative Biology 2021-05-11 Daria Stepanova , Helen M. Byrne , Philip K. Maini , Tomás Alarcón

Reversible electropermeabilization, commonly referred to as electroporation, is a transient increase in cell membrane permeability induced by short, high-voltage electric pulses. We present a stochastically perturbed version of a…

Analysis of PDEs · Mathematics 2026-04-14 Tobias Gebäck , Oleksandr Misiats , Ioanna Motschan-Armen , Irina Pettersson

An approach is suggested for treating multiscale fluctuations in macromolecular systems. The emphasis is on the statistical properties of such fluctuations. The approach is illustrated by a macromolecular system with mesoscopic fluctuations…

Chemical Physics · Physics 2012-08-07 V. I. Yukalov , E. P. Yukalova

We formulate theoretical modeling approaches and develop practical computational simulation methods for investigating the non-equilibrium statistical mechanics of fluid interfaces with passive and active immersed particles. Our approaches…

Soft Condensed Matter · Physics 2024-10-03 Dev Jasuja , Paul J. Atzberger

We examine a biomolecular machine involving a driven, observable process coupled to a hidden process in a kinetically cooperative manner. A stochastic thermodynamics framework is employed to analyze a fluctuation theorem for the…

Statistical Mechanics · Physics 2025-11-14 D. Evan Piephoff , Jianshu Cao