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The COVID-19 pandemic has stimulated the scientific world to intensify virus-related studies, aimed at the development of quick and safe ways of detecting viruses in human body, studying the virus-antibody and virus-cell interactions, and…

The unprecedented outbreak of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), or COVID-19, continues to be a significant worldwide problem. As a result, a surge of new COVID-19 related research has followed suit. The growing…

Machine Learning · Computer Science 2021-07-21 Maksim E. Eren , Nick Solovyev , Chris Hamer , Renee McDonald , Boian S. Alexandrov , Charles Nicholas

The availability of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus data post-COVID has reached exponentially to an enormous magnitude, opening research doors to analyze its behavior. Various studies are conducted by…

Neural and Evolutionary Computing · Computer Science 2025-01-28 Taslim Murad , Prakash Chourasia , Sarwan Ali , Imdad Ullah Khan , Murray Patterson

COVID-19 has claimed more 1 million lives and resulted in over 40 million infections. There is an urgent need to identify drugs that can inhibit SARS-CoV-2. In response, the DOE recently established the Medical Therapeutics project as part…

Currently, the world seeks to find appropriate mitigation techniques to control and prevent the spread of the new SARS-CoV-2. In our paper herein, we present a peculiar Multi-Task Learning framework that jointly predicts the effect of…

Machine Learning · Computer Science 2021-08-24 Bonaventure Chidube Molokwu , Shaon Bhatta Shuvo , Ziad Kobti , Anne Snowdon

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been mutating since it was first sequenced in early January 2020. The genetic variants have developed into a few distinct clusters with different properties. Since the…

Genomics · Quantitative Biology 2020-07-28 Rui Wang , Jiahui Chen , Kaifu Gao , Yuta Hozumi , Changchuan Yin , Guo-Wei Wei

With worldwide concerns surrounding the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), there is a rapidly growing body of literature on the virus. Clinicians, researchers, and policy-makers need a way to effectively search…

Information Retrieval · Computer Science 2020-08-04 Sean MacAvaney , Arman Cohan , Nazli Goharian

There is a near consensus view that SARS-CoV-2 has a natural zoonotic origin; however, several characteristics of SARS-CoV-2 taken together are not easily explained by a natural zoonotic origin hypothesis. These include: a low rate of…

Populations and Evolution · Quantitative Biology 2021-02-10 Rossana Segreto , Yuri Deigin , Kevin McCairn , Alejandro Sousa , Dan Sirotkin , Karl Sirotkin , Jonathan J. Couey , Adrian Jones , Daoyu Zhang

The wide spread of coronavirus disease 2019 (COVID-19) has declared a global health emergency. As one of the most important targets for antibody and drug developments, Spike RBD-ACE2 interface has received extensive attention. Here, using…

Biomolecules · Quantitative Biology 2021-05-14 Yanmei Yang , Yunju Zhang , Yuanyuan Qu , Xuewei Liu , Mingwen Zhao , Yuguang Mu , Weifeng Li

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emergence began in late 2019 and has since spread rapidly worldwide. The characteristics of respiratory immune response to this emerging virus is not clear. Recently,…

Quantitative Methods · Quantitative Biology 2021-10-12 Seyednami Niyakan , Xiaoning Qian

In this study, we investigated the inhibition of SARS-CoV-2 spike glycoprotein with HIV drugs and their combinations. This glycoprotein is essential for the reproduction of the SARS-COV-2 virus, so its inhibition opens new avenues for the…

The determination of the infection fatality rate (IFR) for the novel SARS-CoV-2 coronavirus is a key aim for many of the field studies that are currently being undertaken in response to the pandemic. The IFR together with the basic…

This paper introduces a lossless data compression competition that benchmarks solutions (computer programs) by the compressed size of the 44,981 concatenated SARS-CoV-2 sequences, with a total uncompressed size of 1,339,868,341 bytes. The…

Databases · Computer Science 2020-12-23 Innar Liiv

The global SARS-CoV-2 pandemic is currently putting a massive strain on the world's critical infrastructures. With healthcare systems and internet service providers already struggling to provide reliable service, some operators may,…

The year 2020 has seen an unprecedented COVID-19 pandemic due to the outbreak of a novel strain of coronavirus in 180 countries. In a desperate effort to discover new drugs and vaccines for COVID-19, many scientists are working around the…

Information Retrieval · Computer Science 2020-04-07 Sabber Ahamed , Manar Samad

The novel coronavirus (2019-nCoV) has been declared to be a new international health emergence and no specific drug has been yet identified. Several methods are currently being evaluated such as protease and glycosylated spike (S) protein…

Quantitative Methods · Quantitative Biology 2020-04-14 Nicolò Savioli

The fast and untraceable virus mutations take lives of thousands of people before the immune system can produce the inhibitory antibody. Recent outbreak of novel coronavirus infected and killed thousands of people in the world. Rapid…

Biomolecules · Quantitative Biology 2020-03-20 Rishikesh Magar , Prakarsh Yadav , Amir Barati Farimani

When the novel coronavirus disease SARS-CoV2 (COVID-19) was officially declared a pandemic by the WHO in March 2020, the scientific community had already braced up in the effort of making sense of the fast-growing wealth of data gathered by…

Populations and Evolution · Quantitative Biology 2020-05-25 Timoteo Carletti , Duccio Fanelli , Francesco Piazza

As the year 2020 draws to an end, several new strains have been reported for the SARS-CoV-2 coronavirus, the agent responsible for the COVID-19 pandemic that has afflicted us all this past year. However, it is difficult to comprehend the…

Genomics · Quantitative Biology 2023-06-09 Rene L. Warren , Inanc Birol

To support the ongoing management of viral respiratory diseases, many countries are moving towards an integrated model of surveillance for SARS-CoV-2, influenza, and other respiratory pathogens. While many surveillance approaches catalysed…

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