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Cortical neurons whose activity is recorded in behavioral experiments has been classified into several types such as stimulus-related neurons, delay-period neurons, and reward-related neurons. Moreover, the population activity of neurons…
Humans and animals exhibit a range of interesting behaviors in dynamic environments, and it is unclear how our brains actively reformat this dense sensory information to enable these behaviors. Experimental neuroscience is undergoing a…
Identifying the physiological processes underlying the emergence and maintenance of consciousness is one of the most fundamental problems of neuroscience, with implications ranging from fundamental neuroscience to the treatment of patients…
The brain is a highly complex organ consisting of a myriad of subsystems that flexibly interact and adapt over time and context to enable perception, cognition, and behavior. Understanding the multi-scale nature of the brain, i.e., how…
In neuroscience, researchers have developed informal notions of what it means to reverse engineer a system, e.g., being able to model or simulate a system in some sense. A recent influential paper of Jonas and Kording, that examines a…
One major challenge in neuroscience is the identification of interrelations between signals reflecting neural activity and how information processing occurs in the neural circuits. At the cellular and molecular level, mechanisms of signal…
One of the central problems in neuroscience is reconstructing synaptic connectivity in neural circuits. Synapses onto a neuron can be probed by sequentially stimulating potentially pre-synaptic neurons while monitoring the membrane voltage…
Individual neurons often produce highly variable responses over nominally identical trials, reflecting a mixture of intrinsic "noise" and systematic changes in the animal's cognitive and behavioral state. Disentangling these sources of…
We investigate the sparse functional identification of complex cells and the decoding of visual stimuli encoded by an ensemble of complex cells. The reconstruction algorithm of both temporal and spatio-temporal stimuli is formulated as a…
The brain is immensely complex, with diverse components and dynamic interactions building upon one another to orchestrate a wide range of functions and behaviors. Understanding patterns of these complex interactions and how they are…
This paper presents an algorithm for searching for the minimum number of neurons in fully connected layers of an arbitrary network solving given problem, which does not require multiple training of the network with different number of…
Superconducting optoelectronic loop neurons are a class of circuits potentially conducive to networks for large-scale artificial cognition. These circuits employ superconducting components including single-photon detectors, Josephson…
Understanding how the brain learns to compute functions reliably, efficiently and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could…
Neuroscience has focused on the detailed implementation of computation, studying neural codes, dynamics and circuits. In machine learning, however, artificial neural networks tend to eschew precisely designed codes, dynamics or circuits in…
Biological circuits such as neural or gene regulation networks use internal states to map sensory input to an adaptive repertoire of behavior. Characterizing this mapping is a major challenge for systems biology, and though experiments that…
Modern deep networks are highly complex and their inferential outcome very hard to interpret. This is a serious obstacle to their transparent deployment in safety-critical or bias-aware applications. This work contributes to post-hoc…
We propose a formal mathematical model for sparse representations and active dendrites in neocortex. Our model is inspired by recent experimental findings on active dendritic processing and NMDA spikes in pyramidal neurons. These…
Neurons communicate with downstream systems via sparse and incredibly brief electrical pulses, or spikes. Using these events, they control various targets such as neuromuscular units, neurosecretory systems, and other neurons in connected…
Spiking Neural Networks have earned increased recognition in recent years owing to their biological plausibility and event-driven computation. Spiking neurons are the fundamental building components of Spiking Neural Networks. Those neurons…
Simulation is a third pillar next to experiment and theory in the study of complex dynamic systems such as biological neural networks. Contemporary brain-scale networks correspond to directed graphs of a few million nodes, each with an…