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Related papers: BioDynaMo: a general platform for scalable agent-b…

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Agent-based modeling is indispensable for studying complex systems across many domains. However, existing simulation platforms exhibit two major issues: performance and modularity. Low performance prevents simulations with a large number of…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-17 Lukas Johannes Breitwieser

Agent-based modeling plays an essential role in gaining insights into biology, sociology, economics, and other fields. However, many existing agent-based simulation platforms are not suitable for large-scale studies due to the low…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-04-25 Lukas Breitwieser , Ahmad Hesam , Fons Rademakers , Juan Gómez Luna , Onur Mutlu

Agent-based simulation is an indispensable paradigm for studying complex systems. These systems can comprise billions of agents, requiring the computing resources of multiple servers to simulate. Unfortunately, the state-of-the-art…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-30 Lukas Breitwieser , Ahmad Hesam , Abdullah Giray Yağlıkçı , Mohammad Sadrosadati , Fons Rademakers , Onur Mutlu

Researchers in biology are faced with the tough challenge of developing high-performance computer simulations of their increasingly complex agent-based models. BioDynaMo is an open-source agent-based simulation platform that aims to…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-06-29 Ahmad Hesam , Lukas Breitwieser , Fons Rademakers , Zaid Al-Ars

This paper is a brief update on developments in the BioDynaMo project, a new platform for computer simulations for biological research. We will discuss the new capabilities of the simulator, important new concepts simulation methodology as…

Neural and Evolutionary Computing · Computer Science 2018-01-22 Leonard Johard , Lukas Breitwieser , Alberto Di Meglio , Marco Manca , Manuel Mazzara , Max Talanov

Computer simulations have become a very powerful tool for scientific research. Given the vast complexity that comes with many open scientific questions, a purely analytical or experimental approach is often not viable. For example,…

Neural and Evolutionary Computing · Computer Science 2016-07-12 Roman Bauer , Lukas Breitwieser , Alberto Di Meglio , Leonard Johard , Marcus Kaiser , Marco Manca , Manuel Mazzara , Max Talanov

Computer simulations have become a very powerful tool for scientific research. In order to facilitate research in computational biology, the BioDynaMo project aims at a general platform for biological computer simulations, which should be…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-08-18 Lukas Breitwieser , Roman Bauer , Alberto Di Meglio , Leonard Johard , Marcus Kaiser , Marco Manca , Manuel Mazzara , Fons Rademakers , Max Talanov

Agent-based modeling and network science have been used extensively to advance our understanding of emergent collective behavior in systems that are composed of a large number of simple interacting individuals or agents. With the increasing…

Multiagent Systems · Computer Science 2019-03-14 Marcos Cardinot , Colm O'Riordan , Josephine Griffith , Matjaž Perc

BioDynaMo is a biological processes simulator developed by an international community of researchers and software engineers working closely with neuroscientists. The authors have been working on gene expression, i.e. the process by which…

Quantitative Methods · Quantitative Biology 2018-03-13 Sadyk Sayfullin , Fedor Akhmetov , Manuel Mazzara , Ruslan Mustafin , Victor Rivera

Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly…

Quantitative Methods · Quantitative Biology 2025-04-17 Kerri-Ann Norton , Daniel Bergman , Harsh Vardhan Jain , Trachette Jackson

With recent and rapid advancements in artificial intelligence (AI), understanding the foundation of purposeful behaviour in autonomous agents is crucial for developing safe and efficient systems. While artificial neural networks have…

Artificial Intelligence · Computer Science 2025-08-12 Aswin Paul , Moein Khajehnejad , Forough Habibollahi , Brett J. Kagan , Adeel Razi

Recent advances in large language models (LLMs) have opened new avenues for applying multi-agent systems in very large-scale simulations. However, there remain several challenges when conducting multi-agent simulations with existing…

Multiagent Systems · Computer Science 2024-10-29 Xuchen Pan , Dawei Gao , Yuexiang Xie , Yushuo Chen , Zhewei Wei , Yaliang Li , Bolin Ding , Ji-Rong Wen , Jingren Zhou

We present an approach of using AI to model and simulate biology and life. Why is it important? Because at the core of medicine, pharmacy, public health, longevity, agriculture and food security, environmental protection, and clean energy,…

Artificial Intelligence · Computer Science 2024-12-11 Le Song , Eran Segal , Eric Xing

Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our understanding of immunology and disease pathology. We review various agent-based…

Cell Behavior · Quantitative Biology 2017-12-05 Amy L. Bauer , Catherine A. A. Beauchemin , Alan S. Perelson

Agent-based modeling and simulation tools provide a mature platform for development of complex simulations. They however, have not been applied much in the domain of mainstream modeling and simulation of computer networks. In this article,…

Networking and Internet Architecture · Computer Science 2017-08-07 Muaz A. Niazi , Amir Hussain

Simulation is an essential tool to develop and benchmark autonomous vehicle planning software in a safe and cost-effective manner. However, realistic simulation requires accurate modeling of nuanced and complex multi-agent interactive…

Agent-based modeling is a computational dynamic modeling technique that may be less familiar to some readers. Agent-based modeling seeks to understand the behaviour of complex systems by situating agents in an environment and studying the…

Multiagent Systems · Computer Science 2023-04-19 G. Wade McDonald , Nathaniel D. Osgood

The fundamental understanding of how cells physically interact with each other and their environment is key to understanding their organisation in living tissues. Over the past decades several computational methods have been developed to…

Quantitative Methods · Quantitative Biology 2026-01-22 Paul Van Liedekerke , Jiří Pešek , Kevin Alessandri , Dirk Drasdo

Our understanding of the physics of biological molecules, such as proteins and DNA, is limited because the approximations we usually apply to model inert materials are not in general applicable to soft, chemically inhomogeneous systems. The…

Quantum Physics · Physics 2010-07-13 Sarah Harris , Vivien M. Kendon

We envision the Full-Body AI Agent as a comprehensive AI system designed to simulate, analyze, and optimize the dynamic processes of the human body across multiple biological levels. By integrating computational models, machine learning…

Tissues and Organs · Quantitative Biology 2025-08-28 Aoqi Wang , Jiajia Liu , Jianguo Wen , Yangyang Luo , Zhiwei Fan , Liren Yang , Xi Hu , Ruihan Luo , Yankai Yu , Sophia Li , Weiling Zhao , Xiaobo Zhou
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