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Background: Transcranial magnetic stimulation (TMS) is a powerful tool to investigate neurophysiology of the human brain and treat brain disorders. Traditionally, therapeutic TMS has been applied in a one-size-fits-all approach,…

Background & Aim: Transcranial temporal interference stimulation (TIS) is a novel transcranial electrical stimulation modality that enables focused targeting of deep brain structures. When targeting deep regions, current pathways traverse…

Medical Physics · Physics 2025-11-17 Kanata Yatsuda , Masaki Fukunaga , Wenwei Yu , Jose Gomez-Tames

This paper explores advanced electrode modeling in the context of separate and parallel transcranial electrical stimulation (tES) and electroencephalography (EEG) measurements. We focus on boundary condition based approaches that do not…

Medical Physics · Physics 2016-08-22 Britte Agsten , Sven Wagner , Sampsa Pursiainen , Carsten H. Wolters

Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) is widely used to study the reactivity and connectivity of brain regions for clinical or research purposes. The electromagnetic pulse of the TMS device…

Quantitative Methods · Quantitative Biology 2019-10-30 Panteleimon Vafeidis , Vasilios K. Kimiskidis , Dimitris Kugiumtzis

The primary motor cortex appears to be in the center of transcranial magnetic stimulation (TMS). It is one of few locations that provide directly observable responses, and its physiology serves as model or reference for almost all other TMS…

Neurons and Cognition · Quantitative Biology 2025-07-08 Maryam Farahmandrad , Stefan Goetz

During brain function, groups of neurons fire synchronously. When these groups are large enough, the resulting electrical signals can be measured on the scalp using Electroencephalography (EEG). The amplitude of these signals can be…

Neurons and Cognition · Quantitative Biology 2025-02-05 Jesus Acosta-Elias , Santiago Mendez-Moreno , Omar Vital-Ochoa , Ricardo Espinosa-Tanguma

Background: Calculation of the electric field induced by transcranial magnetic stimulation (TMS) in the brain requires accurate models of the stimulation coils. Reconstructing models from the measured magnetic fields of coils so far worked…

Other Quantitative Biology · Quantitative Biology 2021-12-30 Kristoffer Hougaard Madsen , Maria Drakaki , Axel Thielscher

Transcranial Electrical Stimulation (tES) is a neuromodulation technique that utilizes electrodes on the scalp to stimulate target brain regions. tES has shown promise in treating many neurological conditions, such as stroke rehabilitation…

Systems and Control · Electrical Eng. & Systems 2025-02-04 Chaitanya Goswami , Pulkit Grover

A major shortcoming of medical practice is the lack of an objective measure of conscious level. Impairment of consciousness is common, e.g. following brain injury and seizures, which can also interfere with sensory processing and volitional…

Neurons and Cognition · Quantitative Biology 2025-12-24 Alexis Pomares Pastor , Ines Ribeiro Violante , Gregory Scott

Low-intensity transcranial focused ultrasound (tFUS) is rapidly emerging as a transformative non-invasive brain stimulation (NIBS) modality characterized by high spatial resolution and ability to target deep brain circuits. Unlike…

Neurons and Cognition · Quantitative Biology 2026-04-02 William J. Tyler

The present literature about possible mechanisms behind the effectivity of noninvasive electromagnetic stimulation in major depressive disorder (MDD) is not very rich. Despite extensive research in applications for clinical practice, the…

Neurons and Cognition · Quantitative Biology 2019-12-19 Milena Cukic

This paper discusses the use of the scalp electric field to decode EEG-recorded brain processes. Instead of using bipolar measurements, the scalp electric field is described as a 3-vector field whose orthogonal components are obtained from…

Neurons and Cognition · Quantitative Biology 2013-07-11 C. G. Carvalhaes , J. Acacio de Barros , M. Perreau-Guimarães , P. Suppes

The electromagnetic pulses of rare long (order of seconds) repetitive lightning discharges near strike point (order of 100m) are analyzed and compared to magnetic fields applied in standard clinical transcranial magnetic stimulation (TMS)…

Medical Physics · Physics 2010-10-19 J. Peer , A. Kendl

Transcranial Electrical Stimulation (TCES) and Deep Brain Stimulation (DBS) are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency,…

Neurons and Cognition · Quantitative Biology 2019-07-15 Markus Schütt , Jens Christian Claussen

Transcranial magnetic stimulation (TMS) is a noninvasive medical procedure that can modulate brain activity, and it is widely used in neuroscience and neurology research. Compared to manual operators, robots may improve the outcome of TMS…

Spinal cord injury (SCI) is a debilitating condition that often results in significant motor and sensory deficits, impacting the quality of life. Current rehabilitation methods, including physical therapy and electrical stimulation, offer…

Neurons and Cognition · Quantitative Biology 2024-12-18 Ruidong Cheng , Yuling Shao , Xi Li , Li Zhang , Zehao Sheng , Chenyang Li , Xu Xie , Huilin Mou , Weidong Chen , Shaomin Zhang , Yuchen Xu , Minmin Wang

The interaction between excitation and inhibition is crucial for brain computation. To understand synaptic mechanisms underlying brain function, it is important to separate excitatory and inhibitory inputs to a target neuron. In the…

Neurons and Cognition · Quantitative Biology 2017-10-17 Songting Li , Xiaohui Zhang , Douglas Zhou , David Cai

Transcranial photobiomodulation (tPBM) therapy is an emerging, non-invasive neuromodulation technique that has demonstrated considerable potential in the field of neuropsychiatric disorders. Several studies have found that pulsed wave (PW)…

Neurons and Cognition · Quantitative Biology 2025-12-02 Jiangshan He , Hui Xie , Yuqiang Yang , Chunli Jia , Dan Liang , Lianghua Zhang , Xiaoyu Wang , Tianyi Luo , Zexiao Dong , Huiting Yang , Zhen Yuan , Mingzhe Jiang , Xueli Chen

Neurostimulation using weak electric fields has generated excitement in recent years due to its potential as a medical intervention. However, study of this stimulation modality has been hampered by inconsistent results and large variability…

Neurons and Cognition · Quantitative Biology 2020-01-29 Frances Hutchings , Christopher Thornton , Chencheng Zhang , Yujiang Wang , Marcus Kaiser

Transcranial photobiomodulation is an optical method for non-invasive brain stimulation. The method projects red and near-infrared light through the scalp within 600-1100 nm and low energy within the 1-20 J/cm2 range. Recent studies have…

Numerical Analysis · Mathematics 2022-12-12 Faezeh Ibrahimi , Mehdi Delrobaei