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Over the past few years, technological advances have allowed for measurement of omics data at the cell level, creating a new type of data generally referred to as single-cell (sc) omics. On the other hand, the so-called spatial omics are a…

Joint analysis of multi-omic single-cell data across cohorts has significantly enhanced the comprehensive analysis of cellular processes. However, most of the existing approaches for this purpose require access to samples with complete…

Machine Learning · Computer Science 2024-05-21 Marianne Arriola , Weishen Pan , Manqi Zhou , Qiannan Zhang , Chang Su , Fei Wang

Spatial omics assays allow for the molecular characterisation of cells in their spatial context. Notably, the two main technological streams, imaging-based and high-throughput sequencing-based, can give rise to very different data…

Quantitative Methods · Quantitative Biology 2025-06-26 Martin Emons , Samuel Gunz , Helena L. Crowell , Izaskun Mallona , Reinhard Furrer , Mark D. Robinson

The visual analysis of retinal data contributes to the understanding of a wide range of eye diseases. For the evaluation of cross-sectional studies, ophthalmologists rely on workflows and toolsets established in their work environment. That…

Human-Computer Interaction · Computer Science 2023-01-06 Martin Röhlig , Lars Nonnemann , Hans-Jörg Schulz , Oliver Stachs , Heidrun Schumann

The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and…

Genomics · Quantitative Biology 2024-12-09 Shuang Ge , Shuqing Sun , Huan Xu , Qiang Cheng , Zhixiang Ren

Recent advances in spatial omics technologies have revolutionized our ability to study biological systems with unprecedented resolution. By preserving the spatial context of molecular measurements, these methods enable comprehensive mapping…

Quantitative Methods · Quantitative Biology 2025-09-18 Zhiwei Fan , Tiangang Wang , Kexin Huang , Binwu Ying , Xiaobo Zhou

Recently developed technologies to generate single-cell genomic data have made a revolutionary impact in the field of biology. Multi-omics assays offer even greater opportunities to understand cellular states and biological processes.…

Genomics · Quantitative Biology 2022-01-19 Stefan Stanojevic , Yijun Li , Lana X. Garmire

Epidemiology characterizes the influence of causes to disease and health conditions of defined populations. Cohort studies are population-based studies involving usually large numbers of randomly selected individuals and comprising numerous…

Computer Vision and Pattern Recognition · Computer Science 2015-01-19 Bernhard Preim , Paul Klemm , Helwig Hauser , Katrin Hegenscheid , Steffen Oeltze , Klaus Toennies , Henry Völzke

Spatial omics has transformed our understanding of tissue architecture by preserving spatial context of gene expression patterns. Simultaneously, advances in imaging AI have enabled extraction of morphological features describing the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Eduard Chelebian , Christophe Avenel , Carolina Wählby

Single-cell multi-omics data contain huge information of cellular states, and analyzing these data can reveal valuable insights into cellular heterogeneity, diseases, and biological processes. However, as cell differentiation \& development…

Genomics · Quantitative Biology 2025-08-27 Wuchao Liu , Han Peng , Wengen Li , Yichao Zhang , Jihong Guan , Shuigeng Zhou

Multiplexed imaging data are revolutionizing our understanding of the composition and organization of tissues and tumors. A critical aspect of such tissue profiling is quantifying the spatial relationship relationships among cells at…

Quantitative Methods · Quantitative Biology 2024-05-06 Ajit J. Nirmal , Peter K. Sorger

We developed a new approach comprised of different visualizations for the comparative spatio-temporal analysis of displacement processes in porous media. We aim to analyze and compare ensemble datasets from experiments to gain insight into…

Graphics · Computer Science 2024-01-17 Alexander Straub , Nikolaos Karadimitriou , Guido Reina , Steffen Frey , Holger Steeb , Thomas Ertl

Spatial transcriptomics methods capture cellular measurements such as gene expression and cell types at specific locations in a cell, helping provide a localized picture of tissue health. Traditional visualization techniques superimpose the…

Quantitative Methods · Quantitative Biology 2024-10-16 Siyuan Zhao , G. Elisabeta Marai

With advanced imaging, sequencing, and profiling technologies, multiple omics data become increasingly available and hold promises for many healthcare applications such as cancer diagnosis and treatment. Multimodal learning for integrative…

Genomics · Quantitative Biology 2022-12-20 Sina Tabakhi , Mohammod Naimul Islam Suvon , Pegah Ahadian , Haiping Lu

Multiplexed immunofluorescence microscopy captures detailed measurements of spatially resolved, multiple biomarkers simultaneously, revealing tissue composition and cellular interactions in situ among single cells. The growing scale and…

Software Engineering · Computer Science 2025-06-03 Fang Liu , Rui He , Andrei Bombin , Ahmad B. Abdallah , Omar Eldaghar , Tommy R. Sheeley , Sam E. Ying , George Zaki

Cell detection is a fundamental task in computational pathology that can be used for extracting high-level medical information from whole-slide images. For accurate cell detection, pathologists often zoom out to understand the tissue-level…

Cellular identity and function are linked to both their intrinsic genomic makeup and extrinsic spatial context within the tissue microenvironment. Spatial transcriptomics (ST) offers an unprecedented opportunity to study this, providing in…

Machine Learning · Computer Science 2026-02-16 Rui Yan , Xiaohan Xing , Xun Wang , Zixia Zhou , Md Tauhidul Islam , Lei Xing

Human-in-the-loop data analysis applications necessitate greater transparency in machine learning models for experts to understand and trust their decisions. To this end, we propose a visual analytics workflow to help data scientists and…

Machine Learning · Statistics 2017-10-03 Josua Krause , Aritra Dasgupta , Jordan Swartz , Yindalon Aphinyanaphongs , Enrico Bertini

Next generation astronomical surveys naturally pose challenges for human-centred visualisation and analysis workflows that currently rely on the use of standard desktop display environments. While a significant fraction of the data…

Instrumentation and Methods for Astrophysics · Physics 2023-07-11 C. J. Fluke , D. Vohl , V. A. Kilborn , C. Murugeshan

Modern high-throughput sequencing technologies have enabled us to profile multiple molecular modalities from the same single cell, providing unprecedented opportunities to assay celluar heterogeneity from multiple biological layers.…

Machine Learning · Statistics 2022-05-20 Pengcheng Zeng , Zhixiang Lin
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