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We study the optimal design of switching measurements of small Josephson junction circuits which operate in the macroscopic quantum tunnelling regime. Starting from the D-optimality criterion we derive the optimal design for the estimation…

Superconductivity · Physics 2008-02-07 Juha Karvanen , Juha J. Vartiainen , Andrey Timofeev , Jukka Pekola

Diffusion models (DMs) have recently been introduced as a regularizing prior for PET image reconstruction, integrating DMs trained on high-quality PET images with unsupervised schemes that condition on measured data. While these approaches…

Medical Physics · Physics 2026-03-18 George Webber , Alexander Hammers , Andrew P King , Andrew J Reader

This paper considers the estimation of treatment effects in randomized experiments with complex experimental designs, including cases with interference between units. We develop a design-based estimation theory for arbitrary experimental…

Econometrics · Economics 2025-05-27 Haoge Chang

Cumulative link models have been widely used for ordered categorical responses. Uniform allocation of experimental units is commonly used in practice, but often suffers from a lack of efficiency. We consider D-optimal designs with ordered…

Statistics Theory · Mathematics 2017-11-09 Jie Yang , Liping Tong , Abhyuday Mandal

We analyze and optimize two-level methods applied to a symmetric interior penalty discontinuous Galerkin finite element discretization of a singularly perturbed reaction-diffusion equation. Previous analyses of such methods have been…

Numerical Analysis · Mathematics 2021-03-04 José Pablo Lucero Lorca , Martin Jakob Gander

We present a comprehensive analysis of an algorithm for evaluating high-dimensional polynomials that are invariant under permutations and rotations. The key bottleneck is the contraction of a high-dimensional symmetric and sparse tensor…

Numerical Analysis · Mathematics 2022-02-10 Illia Kaliuzhnyi , Christoph Ortner

Under a generalised estimating equation analysis approach, approximate design theory is used to determine Bayesian D-optimal designs. For two examples, considering simple exchangeable and exponential decay correlation structures, we compare…

Methodology · Statistics 2024-02-16 Laura Etfer , James M. S. Wason , Michael J. Grayling

We consider optimal sensor placement for hyper-parameterized linear Bayesian inverse problems, where the hyper-parameter characterizes nonlinear flexibilities in the forward model, and is considered for a range of possible values. This…

Numerical Analysis · Mathematics 2020-11-24 Nicole Aretz-Nellesen , Peng Chen , Martin A. Grepl , Karen Veroy

Recent developments in the field of computational modeling of fracture have opened up possibilities for designing structures against failure. A special case, called interfacial fracture or delamination, can occur in loaded composite…

Optimization and Control · Mathematics 2022-09-13 Sukhminder Singh , Lukas Pflug , Julia Mergheim , Michael Stingl

This paper presents a new and efficient method for the construction of optimal designs for regression models with dependent error processes. In contrast to most of the work in this field, which starts with a model for a finite number of…

Methodology · Statistics 2015-11-06 Holger Dette , Maria Konstantinou , Anatoly Zhigljavsky

In order to identify important variables that are involved in making optimal treatment decision, Lu et al. (2013) proposed a penalized least squared regression framework for a fixed number of predictors, which is robust against the…

Machine Learning · Statistics 2015-10-16 Chengchun Shi , Rui Song , Wenbin Lu

A class of nonlinear models combining a pharmacokinetic compartmental model and a pharmacodynamic Emax model is introduced. The locally D-optimal (LD) design for a four-parameter composed model is found to be a saturated four-point uniform…

Methodology · Statistics 2008-12-18 X. Fang , A. S. Hedayat

Although recent developments in 3D printing technology have made it possible to fabricate metamaterials with characteristic mechanical properties, it is not easy to fabricate complex shapes containing cavities. In this study, a composite…

Applied Physics · Physics 2023-02-27 Daichi Akamatsu , Yuki Noguchi , Kei Matsushima , Yuji Sato , Jun Yanagimoto , Takayuki Yamada

Robust and semiparametric statistics are of the same historical origin and largely employ the same locally asymptotically normal framework. In our talk, we consider he following more intrinsic connections of both fields: 1) Robust influence…

Statistics Theory · Mathematics 2013-06-25 Helmut Rieder

Complex design problems are common in the scientific and industrial fields. In practice, objective functions or constraints of these problems often do not have explicit formulas, and can be estimated only at a set of sampling points through…

Optimization and Control · Mathematics 2022-10-12 Lulu Zhang , Zhi-Qin John Xu , Yaoyu Zhang

The increasing popularity of regression discontinuity methods for causal inference in observational studies has led to a proliferation of different estimating strategies, most of which involve first fitting non-parametric regression models…

Methodology · Statistics 2018-06-11 Guido Imbens , Stefan Wager

In this paper we provide theoretical support for the so-called "Sigmoidal Gaussian Cox Process" approach to learning the intensity of an inhomogeneous Poisson process on a $d$-dimensional domain. This method was proposed by Adams, Murray…

Statistics Theory · Mathematics 2015-03-03 Alisa Kirichenko , Harry van Zanten

This study presents a generative optimization framework that builds on a fine-tuned diffusion model and reward-directed sampling to generate high-performance engineering designs. The framework adopts a parametric representation of the…

Machine Learning · Computer Science 2025-08-05 Hadi Keramati , Patrick Kirchen , Mohammed Hannan , Rajeev K. Jaiman

We present a collection of algorithms which utilize dimensional reduction to perform mesh refinement and study possibly singular solutions of time-dependent partial differential equations. The algorithms are inspired by constructions used…

Numerical Analysis · Mathematics 2007-06-21 Panagiotis Stinis

We present a rigorous derivation of dimensionally reduced theories for thin sheets of nematic elastomers, in the finite bending regime. Focusing on the case of twist nematic texture, we obtain 2D and 1D models for wide and narrow ribbons…

Analysis of PDEs · Mathematics 2017-02-03 Virginia Agostiniani , Antonio DeSimone