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Protein structure prediction is a critical and longstanding challenge in biology, garnering widespread interest due to its significance in understanding biological processes. A particular area of focus is the prediction of missing loops in…

Delay-coupled electro-optical systems have received much attention for their dynamical properties and their potential use in signal processing. In particular it has recently been demonstrated, using the artificial intelligence algorithm…

Emerging Technologies · Computer Science 2018-02-09 Michiel Hermans , Piotr Antonik , Marc Haelterman , Serge Massar

LLM post-training typically propagates task gradients through the full depth of the model. Although this end-to-end structure is simple and general, it couples task adaptation to full-depth activation storage, long-range backward…

Computation and Language · Computer Science 2026-05-11 Hengyu Shi , Tianyang Han , Peizhe Wang , Zhiling Wang , Xu Yang , Junhao Su

It has been proposed by many researchers that combining deep neural networks with graphical models can create more efficient and better regularized composite models. The main difficulties in implementing this in practice are associated with…

Computer Vision and Pattern Recognition · Computer Science 2020-03-16 Patrick Knöbelreiter , Christian Sormann , Alexander Shekhovtsov , Friedrich Fraundorfer , Thomas Pock

In this study, we investigate how the updating of weights during forward operation and the computation of gradients during backpropagation impact the optimization process, training procedure, and overall performance of the neural network,…

Machine Learning · Computer Science 2024-07-10 Amir Noorizadegan , D. L. Young , Y. C. Hon , C. S. Chen

Despite its widespread use in neural networks, error backpropagation has faced criticism for its lack of biological plausibility, suffering from issues such as the backward locking problem and the weight transport problem. These limitations…

Machine Learning · Computer Science 2024-10-24 Chia-Hsiang Kao , Bharath Hariharan

The neural plausibility of backpropagation has long been disputed, primarily for its use of non-local weight transport $-$ the biologically dubious requirement that one neuron instantaneously measure the synaptic weights of another. Until…

Neurons and Cognition · Quantitative Biology 2020-06-26 Daniel Kunin , Aran Nayebi , Javier Sagastuy-Brena , Surya Ganguli , Jonathan M. Bloom , Daniel L. K. Yamins

The backpropagation algorithm for neural networks is widely felt hard to understand, despite the existence of some well-written explanations and/or derivations. This paper provides a new derivation of this algorithm based on the concept of…

Machine Learning · Computer Science 2022-05-03 Yiping Cheng

When training neural networks for classification tasks with backpropagation, parameters are updated on every trial, even if the sample is classified correctly. In contrast, humans concentrate their learning effort on errors. Inspired by…

Neural and Evolutionary Computing · Computer Science 2023-03-29 Aaron Pache , Mark CW van Rossum

The Massive Parallel Computation (MPC) model is a theoretical framework for popular parallel and distributed platforms such as MapReduce, Hadoop, or Spark. We consider the task of computing a large matching or small vertex cover in this…

Data Structures and Algorithms · Computer Science 2018-07-24 Krzysztof Onak

The ubiquitous backpropagation algorithm requires sequential updates through the network introducing a locking problem. In addition, back-propagation relies on the transpose of forward weight matrices to compute updates, introducing a…

Machine Learning · Computer Science 2023-10-31 David Kappel , Khaleelulla Khan Nazeer , Cabrel Teguemne Fokam , Christian Mayr , Anand Subramoney

Perforated Backpropagation is a neural network optimization technique based on modern understanding of the computational importance of dendrites within biological neurons. This paper explores further experiments from the original…

Machine Learning · Computer Science 2025-06-03 Rorry Brenner , Evan Davis , Rushi Chaudhari , Rowan Morse , Jingyao Chen , Xirui Liu , Zhaoyi You , Laurent Itti

The long-held assumption that backpropagation (BP) is essential for state-of-the-art performance is challenged by this work. We present rigorous, hardware-validated evidence that the Mono-Forward (MF) algorithm, a backpropagation-free…

Machine Learning · Computer Science 2025-11-04 Przemysław Spyra , Witold Dzwinel

Continual learning remains a fundamental challenge in artificial intelligence, with catastrophic forgetting posing a significant barrier to deploying neural networks in dynamic environments. Inspired by biological memory consolidation…

Machine Learning · Computer Science 2025-12-19 Goutham Nalagatla , Shreyas Grandhe

Machine-learning architectures, such as Convolutional Neural Networks (CNNs) are vulnerable to adversarial attacks: inputs crafted carefully to force the system output to a wrong label. Since machine-learning is being deployed in…

Cryptography and Security · Computer Science 2022-11-03 Amira Guesmi , Ihsen Alouani , Khaled N. Khasawneh , Mouna Baklouti , Tarek Frikha , Mohamed Abid , Nael Abu-Ghazaleh

Understanding what graph neural networks can learn, especially their ability to learn to execute algorithms, remains a central theoretical challenge. In this work, we prove exact learnability results for graph algorithms under…

Machine Learning · Computer Science 2026-02-02 Muhammad Fetrat Qharabagh , Artur Back de Luca , George Giapitzakis , Kimon Fountoulakis

Nonlinear Parametric Optimization Network (NLPOpt-Net) is an unsupervised learning architecture to solve constrained nonlinear programs (NLP). Given the structure of an NLP, it learns the parametric solution maps with guaranteed constraint…

Machine Learning · Computer Science 2026-05-04 Bimol Nath Roy , Rahul Golder , MM Faruque Hasan

Additive manufacturing using 2-Photon Polymerization (2PP, aka direct laser writing DLW) enables the fabrication of almost arbitrary complex 3D structures from the meso to the submicron scale. However, deviations between the anticipated…

Optics · Physics 2025-12-01 Sven Enns , Julian Hering-Stratemeier , Georg von Freymann

Large language models (LLMs) have achieved remarkable success, yet aligning their generations with human preferences remains a critical challenge. Existing approaches to preference modeling often rely on an explicit or implicit reward…

Computation and Language · Computer Science 2025-05-09 Zhuocheng Gong , Jian Guan , Wei Wu , Huishuai Zhang , Dongyan Zhao

Feedback-rich neural architectures can regenerate earlier representations and inject temporal context, making them a natural setting for strictly local synaptic plasticity. Existing literature raises doubt about whether a minimal,…

Neural and Evolutionary Computing · Computer Science 2026-02-03 Josh Li , Fow-sen Choa