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Estimating and testing for differences in molecular phenotypes (e.g. gene expression, chromatin accessibility, transcription factor binding) across conditions is an important part of understanding the molecular basis of gene regulation.…

A flexible semiparametric class of models is introduced that offers an alternative to classical regression models for count data as the Poisson and negative binomial model, as well as to more general models accounting for excess zeros that…

Methodology · Statistics 2020-03-30 Moritz Berger , Gerhard Tutz

By learning the gradient of smoothed data distributions, diffusion models can iteratively generate samples from complex distributions. The learned score function enables their generalization capabilities, but how the learned score relates…

Machine Learning · Computer Science 2024-12-16 Binxu Wang , John J. Vastola

Because of its mathematical tractability, the Gaussian mixture model holds a special place in the literature for clustering and classification. For all its benefits, however, the Gaussian mixture model poses problems when the data is skewed…

Applications · Statistics 2020-11-19 Michael P. B. Gallaugher , Paul D. McNicholas , Volodymyr Melnykov , Xuwen Zhu

Approximate Bayesian Computation is a family of likelihood-free inference techniques that are well-suited to models defined in terms of a stochastic generating mechanism. In a nutshell, Approximate Bayesian Computation proceeds by computing…

Computation · Statistics 2010-07-28 Michael Blum

Univariate regression models have rich literature for counting data. However, this is not the case for multivariate count data. Therefore, we present the Multivariate Generalized Linear Mixed Models framework that deals with a multivariate…

One aspect of Poisson approximation is that the support of the random variable of interest is often finite while the support of the Poisson distribution is not. In this paper we will remedy this by examining truncated negative binomial (of…

Probability · Mathematics 2017-05-02 H. L. Gan

In multivariate statistics, the question of finding direct interactions can be formulated as a problem of network inference - or network reconstruction - for which the Gaussian graphical model (GGM) provides a canonical framework.…

Methodology · Statistics 2018-06-11 Julien Chiquet , Mahendra Mariadassou , Stéphane Robin

In statistical modeling of computer experiments sometimes prior information is available about the underlying function. For example, the physical system simulated by the computer code may be known to be monotone with respect to some or all…

Methodology · Statistics 2014-06-17 Shirin Golchi , Derek R. Bingham , Hugh Chipman , David A. Campbell

[ABRIDGED] The Cash statistic, also known as the C stat, is commonly used for the analysis of low-count Poisson data, including data with null counts for certain values of the independent variable. The use of this statistic is especially…

Methodology · Statistics 2020-09-18 Massimiliano Bonamente , David Spence

Gaussian graphical regressions have emerged as a powerful approach for regressing the precision matrix of a Gaussian graphical model on covariates, which, unlike traditional Gaussian graphical models, can help determine how graphs are…

Methodology · Statistics 2025-01-17 Xuran Meng , Jingfei Zhang , Yi Li

We approximate the distribution of the sum of independent but not necessarily identically distributed Bernoulli random variables using a shifted binomial distribution where the three parameters (the number of trials, the probability of…

Probability · Mathematics 2010-04-02 Vydas Čekanavičius , Erol A. Peköz , Adrian Röllin , Michael Shwartz

There has recently been considerable interest in addressing the problem of unifying distributed statistical analyses into a single coherent inference. This problem naturally arises in a number of situations, including in big-data settings,…

Methodology · Statistics 2021-02-04 Hongsheng Dai , Murray Pollock , Gareth Roberts

Gaussian distributions are widely used in Bayesian variational inference to approximate intractable posterior densities, but the ability to accommodate skewness can improve approximation accuracy significantly, when data or prior…

Methodology · Statistics 2025-02-05 Linda S. L. Tan , Aoxiang Chen

We analyze here in details the probability to find a given number of particles in a finite volume inside a normal or superfluid finite system. This probability, also known as counting statistics, is obtained using projection operator…

Nuclear Theory · Physics 2020-01-22 Denis Lacroix , Sakir Ayik

Small-angle X-ray and neutron scattering (SAXS and SANS) are powerful techniques in material science and soft matter. In this study, it was addressed how multiple SAXS or SANS datasets are best weighted when doing simultaneous fitting.…

Soft Condensed Matter · Physics 2025-05-30 Andreas Haahr Larsen

Monitoring plant and animal populations is an important goal for both academic research and management of natural resources. Successful management of populations often depends on obtaining estimates of their mean or total over a region. The…

Methodology · Statistics 2014-10-14 Jay M. Ver Hoef , John K. Jansen

In this paper we propose a procedure to evaluate Bayesian confidence intervals in counting experiments where both signal and background fluctuations are described by the Poisson statistics. The results obtained when the method is applied to…

Data Analysis, Statistics and Probability · Physics 2015-03-19 F. Loparco , M. N. Mazziotta

Small-angle X-ray and neutron scattering are widely used to investigate soft matter and biophysical systems. The experimental errors are essential when assessing how well a hypothesized model fits the data. Likewise, they are important when…

Data Analysis, Statistics and Probability · Physics 2022-04-20 Andreas Haahr Larsen , Martin Cramer Pedersen

We consider the problem of inferring an unknown number of clusters in replicated multinomial data. Under a model based clustering point of view, this task can be treated by estimating finite mixtures of multinomial distributions with or…

Methodology · Statistics 2023-07-07 Panagiotis Papastamoulis