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Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for elucidating the three-dimensional structure of proteins and other biologically significant complexes at near-atomic resolution. It is an imaging…

Computational Physics · Physics 2020-04-01 Amit Singer , Fred J. Sigworth

In computational imaging, hardware for signal sampling and software for object reconstruction are designed in tandem for improved capability. Examples of such systems include computed tomography (CT), magnetic resonance imaging (MRI), and…

Image and Video Processing · Electrical Eng. & Systems 2022-11-01 Andrew Olsen , Yolanda Hu , Vidya Ganapati

The use of computed tomography (CT) imaging has become of increasing interest to academic areas outside of the field of medical imaging and industrial inspection, e.g., to biology and cultural heritage research. The pecularities of these…

Image and Video Processing · Electrical Eng. & Systems 2020-11-16 Florian Schiffers , Thomas Bochynek , Andre Aichert , Tobias Würfl , Michael Rubenstein , Oliver Cossairt

Single particle cryo-electron microscopy has become a critical tool in structural biology over the last decade, able to achieve atomic scale resolution in three dimensional models from hundreds of thousands of (noisy) two-dimensional…

Numerical Analysis · Mathematics 2023-07-19 Aaditya V. Rangan , Leslie Greengard

Medical imaging modalities have revolutionized health-care approaches by offering a better understanding of the human anatomy. Discovery of x-rays allowed the exploiting of the micro-scaled information of human anatomy. Computed tomography…

Medical Physics · Physics 2018-09-18 Sanam Assili

The recovery of severely damaged ancient written documents has proven to be a major challenge for many scientists, mainly due to the impracticality of physical unwrapping them. Non-destructive techniques, such as X-ray computed tomography…

Image and Video Processing · Electrical Eng. & Systems 2025-05-05 Sonia Foschiatti , Axel Kittenberger , Otmar Scherzer

Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method to resolve biological macromolecules. In a cryo-EM experiment, the microscope produces…

Information Theory · Computer Science 2022-10-28 Tamir Bendory , Nicolas Boumal , William Leeb , Eitan Levin , Amit Singer

X-ray single particle imaging involves the measurement of a large number of noisy diffraction patterns of isolated objects in random orientations. The missing information about these patterns is then computationally recovered in order to…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Kartik Ayyer

A simple and robust experiment demonstrating computational ghost imaging with structured illumination and a single-pixel detector has been performed. Our experimental setup utilizes a general computer for generating pseudo-randomly patterns…

Optics · Physics 2015-02-10 Lijun Song , Cheng Zhou , Li Chen , Xiaoguang Wang , Jing Cheng

Computed tomography (CT) provides high spatial resolution visualization of 3D structures for scientific and clinical applications. Traditional analytical/iterative CT reconstruction algorithms require hundreds of angular data samplings, a…

Image and Video Processing · Electrical Eng. & Systems 2024-11-14 Di Xu , Yang Yang , Hengjie Liu , Qihui Lyu , Martina Descovich , Dan Ruan , Ke Sheng

In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Jiakai Zhang , Qihe Chen , Yan Zeng , Wenyuan Gao , Xuming He , Zhijie Liu , Jingyi Yu

We combine advanced image reconstruction techniques from computed X-ray micro tomography (XCT) with state-of-the-art discrete element method simulations (DEM) to study granular materials. This "virtual-laboratory" platform allows us to…

Soft Condensed Matter · Physics 2010-07-13 Gary W Delaney , T. Di Matteo , Tomaso Aste

Cryo-electron microscopy (cryo-EM) is an emerging experimental method to characterize the structure of large biomolecular assemblies. Single particle cryo-EM records 2D images (so-called micrographs) of projections of the three-dimensional…

Applications · Statistics 2013-12-02 Mikhail Langovoy , Michael Habeck , Bernhard Schoelkopf

This study starts from the counter-intuitive question of how we can render a conventional stiff, non-stretchable and even brittle material conformable so that it can fully wrap around a curved surface, such as a sphere, without failure.…

Computational Geometry · Computer Science 2018-12-31 Yu-Ki Lee , Zhonghua Xi , Young-Joo Lee , Yun-Hyeong Kim , Yue Hao , Young-Chang Joo , Changsoon Kim , Jyh-Ming Lien , In-Suk Choi

We integrate a small and portable medical x-ray device with mechanical testing equipment to enable in-situ, non-invasive measurements of a granular material's response to mechanical loading. We employ an orthopedic C-arm as the x-ray source…

In this paper we broadly consider techniques which utilize projections on rays for data collection, with particular emphasis on optical techniques. We formulate a variety of imaging techniques as either special cases or extensions of…

Computer Vision and Pattern Recognition · Computer Science 2014-02-12 Keith Dillon , Yeshaiahu Fainman

Cryo-Electron Microscopy (Cryo-EM) is a Nobel prize-winning technology for determining the 3D structure of particles at near-atomic resolution. A fundamental step in the recovering of the 3D single-particle structure is to align its 2D…

Image and Video Processing · Electrical Eng. & Systems 2021-01-12 Koby Bibas , Gili Weiss-Dicker , Dana Cohen , Noa Cahan , Hayit Greenspan

Computerized tomography (CT) has been used for decades by medical professionals to detect and diagnose injuries and ailments. CT scanners are based on interesting physics, but due to their bulk, cost, and safety, hands on experience with a…

Physics Education · Physics 2021-01-28 Vincent Daley , Owen Paetkau , Mark Paetkau

Computational ghost imaging retrieves the spatial information of a scene using a single pixel detector. By projecting a series of known random patterns and measuring the back reflected intensity for each one, it is possible to reconstruct a…

Computed tomography has propelled scientific advances in fields from biology to materials science. This technology allows for the elucidation of 3-dimensional internal structure by the attenuation of x-rays through an object at different…

Computer Vision and Pattern Recognition · Computer Science 2022-11-02 Rey Mendoza , Minh Nguyen , Judith Weng Zhu , Vincent Dumont , Talita Perciano , Juliane Mueller , Vidya Ganapati
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