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Count outcomes in longitudinal studies are frequent in clinical and engineering studies. In frequentist and Bayesian statistical analysis, methods such as Mixed linear models allow the variability or correlation within individuals to be…

Methodology · Statistics 2024-07-15 Alejandra Estefanía Patiño Hoyos , Johnatan Cardona Jiménez

A/B testing is one of the most successful applications of statistical theory in modern Internet age. One problem of Null Hypothesis Statistical Testing (NHST), the backbone of A/B testing methodology, is that experimenters are not allowed…

Applications · Statistics 2016-02-18 Alex Deng , Jiannan Lu , Shouyuan Chen

While Null Hypothesis Significance Testing (NHST) remains a widely used statistical tool, it suffers from several shortcomings in its common usage, such as conflating statistical and practical significance, the formulation of inappropriate…

As a convention, p-value is often computed in frequentist hypothesis testing and compared with the nominal significance level of 0.05 to determine whether or not to reject the null hypothesis. The smaller the p-value, the more significant…

Methodology · Statistics 2020-02-25 Haolun Shi , Guosheng Yin

The logical and practical difficulties associated with research interpretation using P values and null hypothesis significance testing have been extensively documented. This paper describes an alternative, likelihood-based approach to…

Methodology · Statistics 2021-09-21 Nicholas Adams , Gerard O'Reilly

To perform statistical inference for time series, one should be able to assess if they present deterministic or stochastic trends. For univariate analysis one way to detect stochastic trends is to test if the series has unit roots, and for…

Statistics Theory · Mathematics 2020-09-15 Marcio Alves Diniz , Carlos Alberto de Braganca Pereira , Julio Michael Stern

Given the well-known and fundamental problems with hypothesis testing via classical (point-form) significance tests, there has been a general move to alternative approaches, often focused on the Bayesian t-test. We show that the Bayesian…

Statistics Theory · Mathematics 2022-11-07 Fintan Costello , Paul Watts

Since its introduction by Fisher, the method of hypothesis testing that relies on computing error probabilities has witnessed several developments. Perhaps the most significant development was the seminal contributions of Neyman and Pearson…

Other Statistics · Statistics 2026-05-08 Reason Machete

The following zero-sum game between nature and a statistician blends Bayesian methods with frequentist methods such as p-values and confidence intervals. Nature chooses a posterior distribution consistent with a set of possible priors. At…

Methodology · Statistics 2011-07-19 David R. Bickel

Much of science is (rightly or wrongly) driven by hypothesis testing. Even in situations where the hypothesis testing paradigm is correct, the common practice of basing inferences solely on p-values has been under intense criticism for over…

Methodology · Statistics 2015-12-31 M. J. Bayarri , Daniel J. Benjamin , James O. Berger , Thomas M. Sellke

Persistent homology is a vital tool for topological data analysis. Previous work has developed some statistical estimators for characteristics of collections of persistence diagrams. However, tools that provide statistical inference for…

Applications · Statistics 2016-02-23 Andrew Robinson , Katharine Turner

A standard practice in statistical hypothesis testing is to mention the p-value alongside the accept/reject decision. We show the advantages of mentioning an e-value instead. With p-values, it is not clear how to use an extreme observation…

Methodology · Statistics 2024-04-04 Peter Grünwald

It is now widely accepted that the standard inferential toolkit used by the scientific research community -- null-hypothesis significance testing (NHST) -- is not fit for purpose. Yet despite the threat posed to the scientific enterprise,…

Methodology · Statistics 2023-11-10 Leonhard Held , Robert Matthews , Manuela Ott , Samuel Pawel

Despite their importance in supporting experimental conclusions, standard statistical tests are often inadequate for research areas, like the life sciences, where the typical sample size is small and the test assumptions difficult to…

Methodology · Statistics 2011-04-15 Pietro Berkes , Jozsef Fiser

Statistical inference has undergone a profound transformation over the past decade, evolving from a significance-testing paradigm toward a comprehensive, transparency-driven framework embedded within the broader open science ecosystem.…

Methodology · Statistics 2026-04-07 Aswini Kumar Patra

In recent years, empirical Bayesian (EB) inference has become an attractive approach for estimation in parametric models arising in a variety of real-life problems, especially in complex and high-dimensional scientific applications.…

Methodology · Statistics 2023-03-01 Hien D Nguyen , Mayetri Gupta

We introduce a powerful deep classifier two-sample test for high-dimensional data based on E-values, called E-value Classifier Two-Sample Test (E-C2ST). Our test combines ideas from existing work on split likelihood ratio tests and…

Methodology · Statistics 2024-05-01 Teodora Pandeva , Tim Bakker , Christian A. Naesseth , Patrick Forré

P-values are widely used in both the social and natural sciences to quantify the statistical significance of observed results. The recent surge of big data research has made the p-value an even more popular tool to test the significance of…

Applications · Statistics 2023-01-05 Bertie Vidgen , Taha Yasseri

In this study, we propose a two-stage procedure for hypothesis testing, where the first stage is conventional hypothesis testing and the second is an equivalence testing procedure using an introduced Empirical Equivalence Bound. In 2016,…

Methodology · Statistics 2020-01-01 Yi Zhao , Brian S. Caffo , Joshua B. Ewen

There has been a tremendous methodological development of Bayes factors for hypothesis testing in the social and behavioral sciences, and related fields. This development is due to the flexibility of the Bayes factor for testing multiple…