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There exist numerous diagnostic tasks in pathology. Conventional computational pathology formulates and tackles them as independent and individual image classification problems, thereby resulting in computational inefficiency and high…
Active Learning (AL) has the potential to solve a major problem of digital pathology: the efficient acquisition of labeled data for machine learning algorithms. However, existing AL methods often struggle in realistic settings with…
Age related macular degeneration (AMD) is one of the major causes for blindness in the elderly population. In this report, we propose deep learning based methods for retinal analysis using color fundus images for computer aided diagnosis of…
Retinal vessel segmentation based on deep learning requires a lot of manual labeled data. That is time-consuming, laborious and professional. What is worse, the acquisition of abundant fundus images is difficult. These problems are more…
Early diagnosis of melanoma, which can save thousands of lives, relies heavily on the analysis of dermoscopic images. One crucial diagnostic criterion is the identification of unusual pigment network (PN). However, distinguishing between…
Glaucoma leads to permanent vision disability by damaging the optical nerve that transmits visual images to the brain. The fact that glaucoma does not show any symptoms as it progresses and cannot be stopped at the later stages, makes it…
Fundus photography has routinely been used to document the presence and severity of retinal degenerative diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) in clinical practice, for which the…
In the real world, medical datasets often exhibit a long-tailed data distribution (i.e., a few classes occupy the majority of the data, while most classes have only a limited number of samples), which results in a challenging long-tailed…
The segmentation of retinal vessels is of significance for doctors to diagnose the fundus diseases. However, existing methods have various problems in the segmentation of the retinal vessels, such as insufficient segmentation of retinal…
Purpose: To evaluate nerve fiber layer (NFL) reflectance for glaucoma diagnosis using a large dataset. Methods: Participants were imaged with 4.9mm ONH scans using spectral-domain optical coherence tomography (OCT). The NFL reflectance map…
Microaneurysms (MAs) are one of the earliest signs of diabetic retinopathy (DR), a frequent complication of diabetes that can lead to visual impairment and blindness. Adaptive optics scanning laser ophthalmoscopy (AOSLO) provides real-time…
Central palsy is a form of facial paralysis that requires urgent medical attention and has to be differentiated from other, similar conditions such as peripheral palsy. To aid in fast and accurate diagnosis of this condition, we propose a…
Active learning is considered a viable solution to alleviate the contradiction between the high dependency of deep learning-based segmentation methods on annotated data and the expensive pixel-level annotation cost of medical images.…
Red-lesions, microaneurysms (MAs) and hemorrhages (HMs), are the early signs of diabetic retinopathy (DR). The automatic detection of MAs and HMs on retinal fundus images is a challenging task. Most of the existing methods detect either…
Ocular diseases, including diabetic retinopathy and glaucoma, present a significant public health challenge due to their high prevalence and potential for causing vision impairment. Early and accurate diagnosis is crucial for effective…
Purpose: To classify eyes as slow or fast glaucoma progressors in patients with primary angle closure glaucoma (PACG) using an integrated approach combining optic nerve head (ONH) structural features and sector-based visual field (VF)…
Melanoma is the deadliest form of skin cancer. While curable with early detection, only highly trained specialists are capable of accurately recognizing the disease. As expertise is in limited supply, automated systems capable of…
In ophthalmology, intravitreal operative medication therapy (IVOM) is a widespread treatment for diseases related to the age-related macular degeneration (AMD), the diabetic macular edema (DME), as well as the retinal vein occlusion (RVO).…
Reliable large-scale cell detection and segmentation is the fundamental first step to understanding biological processes in the brain. The ability to phenotype cells at scale can accelerate preclinical drug evaluation and system-level brain…
Mitochondria segmentation in electron microscopy images is essential in neuroscience. However, due to the image degradation during the imaging process, the large variety of mitochondrial structures, as well as the presence of noise,…