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Experiments on particles' motion in living cells show that it is often subdiffusive. This subdiffusion may be due to trapping, percolation-like structures, or viscoelatic behavior of the medium. While the models based on trapping (leading…

Disordered Systems and Neural Networks · Physics 2015-06-11 Yasmine Meroz , Igor M. Sokolov , Joseph Klafter

A spatio-temporal evolution of chemicals appearing in a reversible enzyme reaction and modelled by a four component reaction-diffusion system with the reaction terms obtained by the law of mass action is considered. The large time behaviour…

Analysis of PDEs · Mathematics 2016-10-25 Jan Elias

Many approaches to modelling reaction-diffusion systems with anomalous transport rely on deterministic equations and ignore fluctuations arising due to finite particle numbers. Starting from an individual-based model we use a…

Statistical Mechanics · Physics 2019-05-29 Joseph W. Baron , Tobias Galla

Ratchet effects can appear for particles interacting with an asymmetric potential under ac driving or for a thermal system in which a substrate is periodically flashed. Here, we show that a new type of collective ratchet effect can arise…

Soft Condensed Matter · Physics 2025-07-16 C. Reichhardt , C. J. O. Reichhardt

The crossover between dispersion patterns has been frequently observed in various systems. Inspired by the pathway-based kinetic model for E. coli chemotaxis that accounts for the intracellular adaptation process and noise, we propose a…

Analysis of PDEs · Mathematics 2025-01-07 Zhe Xue , Weiran Sun , Zhennan Zhou , Min Tang

We show that the Turing patterns in reaction systems with subdiffusion can be replicated in an effective system with Markovian cross-diffusion. The effective system has the same Turing instability as the original system, and the same…

Pattern Formation and Solitons · Physics 2020-01-29 Joseph W. Baron , Tobias Galla

We present a simple model based on a reaction-diffusion equation to explain pattern formation in a multicellular bacterium (Streptomyces). We assume competition for resources as the basic mechanism that leads to pattern formation; in…

Biological Physics · Physics 2007-05-23 M. Bezzi , A. Ciliberto , A. Mengoni

Key enzymatic processes in biology use the nonequilibrium error correction mechanism called kinetic proofreading to enhance their specificity. Kinetic proofreading typically requires several dedicated structural features in the enzyme, such…

Molecular Networks · Quantitative Biology 2020-05-26 Vahe Galstyan , Kabir Husain , Fangzhou Xiao , Arvind Murugan , Rob Phillips

We study chemically driven running droplets on a partially wetting solid substrate by means of coupled evolution equations for the thickness profile of the droplets and the density profile of an adsorbate layer. Two models are introduced…

Soft Condensed Matter · Physics 2007-05-23 K. John , M. Baer , U. Thiele

We present results for collective diffusion of adatoms on a stepped substrate with a submonolayer coverage. We study the combined effect of the additional binding at step edge, the Schwoebel barrier, the enhanced diffusion along step edges,…

Condensed Matter · Physics 2009-10-28 Juha Merikoski , See-Chen Ying

Multistationarity in biological systems is a mechanism of cellular decision making. In particular, signaling pathways regulated by protein phosphorylation display features that facilitate a variety of responses to different biological…

Subcellular Processes · Quantitative Biology 2011-07-05 Elisenda Feliu , Carsten Wiuf

Biological nanomachines are nanometer-size macromolecular complexes that catalyze chemical reactions in the presence of substrate molecules. The catalytic functions carried out by such nanomachines in the cytoplasm, and biological membranes…

Soft Condensed Matter · Physics 2022-11-22 Yuto Hosaka , Shigeyuki Komura

Numerical simulations of a simple reaction--diffusion model reveal a surprising variety of irregular spatio--temporal patterns. These patterns arise in response to finite--amplitude perturbations. Some of them resemble the steady irregular…

patt-sol · Physics 2009-10-22 John E. Pearson

Molecular agitation more rapid than thermal Brownian motion is reported for cellular environments, motor proteins, synthetic molecular motors, enzymes, and common chemical reactions, yet that chemical activity couples to molecular motion…

Soft Condensed Matter · Physics 2022-06-08 Ah-Young Jee , Tsvi Tlusty , Steve Granick

Motile bacteria can migrate along chemical gradients in a process known as chemotaxis. When exposed to uniform environmental stress, Escherichia coli cells coordinate their chemotactic responses to form millimeter-sized condensates…

Biological Physics · Physics 2025-05-02 Nir Livne , Ady Vaknin , Oded Agam

Motor enzymes catalyze chemical reactions, like the hydrolysis of ATP, and in the process they also perform work. Recent studies indicate that motor enzymes perform work with specific intermediate steps in their catalyzed reactions,…

Biological Physics · Physics 2007-05-23 Josh E. Baker

Calcium is an ubiquitous second messenger that triggers a plethora of key physiological responses. The events are initiated in micro- or nano-sized compartments and determined by the complex interactions with calcium-binding proteins and…

Subcellular Processes · Quantitative Biology 2013-05-01 S. L. Mironov

Single-enzyme catalysis offers a promising approach for unravelling the dynamic behaviour of individual enzymes as they undergo a reaction, revealing the complex heterogeneity that is lost in the averaged ensembles. Here we demonstrate…

Transport across heterogeneous, patchy environments is a ubiquitous phenomenon spanning fields of study including ecological movement, intracellular transport and regions of specialised function in a cell. These regions or patches may be…

Statistical Mechanics · Physics 2017-10-06 Sergei Fedotov , Helena Stage

During batch growth on mixtures of two growth-limiting substrates, microbes consume the substrates either sequentially or simultaneously. These growth patterns are manifested in all types of bacteria and yeasts. The ubiquity of these growth…

Cell Behavior · Quantitative Biology 2008-01-09 Jason T. Noel , Atul Narang