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Word embeddings have found their way into a wide range of natural language processing tasks including those in the biomedical domain. While these vector representations successfully capture semantic and syntactic word relations, hidden…

With the growing popularity of deep-learning based NLP models, comes a need for interpretable systems. But what is interpretability, and what constitutes a high-quality interpretation? In this opinion piece we reflect on the current state…

Computation and Language · Computer Science 2020-04-29 Alon Jacovi , Yoav Goldberg

For optimization models to be used in practice, it is crucial that users trust the results. A key factor in this aspect is the interpretability of the solution process. A previous framework for inherently interpretable optimization models…

Optimization and Control · Mathematics 2026-02-13 Marc Goerigk , Michael Hartisch , Sebastian Merten , Kartikey Sharma

Recent years have seen a growing interest in methods for predicting an unknown variable of interest, such as a subject's diagnosis, from medical images depicting its anatomical-functional effects. Methods based on discriminative modeling…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Chiara Mauri , Stefano Cerri , Oula Puonti , Mark Mühlau , Koen Van Leemput

Although deep language representations have become the dominant form of language featurization in recent years, in many settings it is important to understand a model's decision-making process. This necessitates not only an interpretable…

Computation and Language · Computer Science 2023-06-05 Victoria Lin , Louis-Philippe Morency

High-stakes applications require AI-generated models to be interpretable. Current algorithms for the synthesis of potentially interpretable models rely on objectives or regularization terms that represent interpretability only coarsely…

Machine Learning · Computer Science 2021-04-28 Marco Virgolin , Andrea De Lorenzo , Francesca Randone , Eric Medvet , Mattias Wahde

In a multi-modeling based approach, the system under development is described by several models that represent various perspectives and concerns. Obviously, these partial representations are less complex than the global model, but they need…

Software Engineering · Computer Science 2015-12-24 Youness Laghouaouta , Adil Anwar , Mahmoud Nassar

Interpretability is the study of explaining models in understandable terms to humans. At present, interpretability is divided into two paradigms: the intrinsic paradigm, which believes that only models designed to be explained can be…

Machine Learning · Computer Science 2024-11-14 Andreas Madsen , Himabindu Lakkaraju , Siva Reddy , Sarath Chandar

For machine learning models to be most useful in numerous sociotechnical systems, many have argued that they must be human-interpretable. However, despite increasing interest in interpretability, there remains no firm consensus on how to…

Machine Learning · Computer Science 2021-02-03 Andrew Slavin Ross , Nina Chen , Elisa Zhao Hang , Elena L. Glassman , Finale Doshi-Velez

Artificial Intelligence has emerged as a useful aid in numerous clinical applications for diagnosis and treatment decisions. Deep neural networks have shown same or better performance than clinicians in many tasks owing to the rapid…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Zohaib Salahuddin , Henry C Woodruff , Avishek Chatterjee , Philippe Lambin

Deformable image registration poses a challenging problem where, unlike most deep learning tasks, a complex relationship between multiple coordinate systems has to be considered. Although data-driven methods have shown promising…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Vasiliki Sideri-Lampretsa , Nil Stolt-Ansó , Huaqi Qiu , Julian McGinnis , Wenke Karbole , Martin Menten , Daniel Rueckert

Complex deep learning models show high prediction tasks in various clinical prediction tasks but their inherent complexity makes it more challenging to explain model predictions for clinicians and healthcare providers. Existing research on…

Machine Learning · Computer Science 2026-02-06 Sayantan Kumar , Sean C. Yu , Thomas Kannampallil , Zachary Abrams , Andrew Michelson , Philip R. O. Payne

Interpretability is often an essential requirement in medical imaging. Advanced deep learning methods are required to address this need for explainability and high performance. In this work, we investigate whether additional information…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Luisa Gallee , Meinrad Beer , Michael Goetz

With machine learning models being increasingly used to aid decision making even in high-stakes domains, there has been a growing interest in developing interpretable models. Although many supposedly interpretable models have been proposed,…

Artificial Intelligence · Computer Science 2021-08-17 Forough Poursabzi-Sangdeh , Daniel G. Goldstein , Jake M. Hofman , Jennifer Wortman Vaughan , Hanna Wallach

Interpreting the internal activations of neural networks can produce more faithful explanations of their behavior, but is difficult due to the complex structure of activation space. Existing approaches to scalable interpretability use…

Artificial Intelligence · Computer Science 2025-12-18 Vincent Huang , Dami Choi , Daniel D. Johnson , Sarah Schwettmann , Jacob Steinhardt

The ability to interpret machine learning models has become increasingly important now that machine learning is used to inform consequential decisions. We propose an approach called model extraction for interpreting complex, blackbox…

Machine Learning · Computer Science 2018-03-14 Osbert Bastani , Carolyn Kim , Hamsa Bastani

Many statistical models have high accuracy on test benchmarks, but are not explainable, struggle in low-resource scenarios, cannot be reused for multiple tasks, and cannot easily integrate domain expertise. These factors limit their use,…

Computation and Language · Computer Science 2021-09-29 Andrew Lee , Jonathan K. Kummerfeld , Lawrence C. An , Rada Mihalcea

Many real-world systems can be usefully represented as sets of interacting components. Examples include computational systems, such as query processors and compilers, natural systems, such as cells and ecosystems, and social systems, such…

Artificial Intelligence · Computer Science 2025-03-18 Purva Pruthi , David Jensen

The pursuit of interpretable artificial intelligence has led to significant advancements in the development of methods that aim to explain the decision-making processes of complex models, such as deep learning systems. Among these methods,…

Machine Learning · Computer Science 2024-10-29 Yihao Zhang

The last decade has seen huge progress in the development of advanced machine learning models; however, those models are powerless unless human users can interpret them. Here we show how the mind's construction of concepts and meaning can…

Machine Learning · Statistics 2016-07-04 Nick Condry