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In this paper we propose a deep learning approach for segmenting sub-cortical structures of the human brain in Magnetic Resonance (MR) image data. We draw inspiration from a state-of-the-art Fully-Convolutional Neural Network (F-CNN)…

Computer Vision and Pattern Recognition · Computer Science 2016-02-08 Mahsa Shakeri , Stavros Tsogkas , Enzo Ferrante , Sarah Lippe , Samuel Kadoury , Nikos Paragios , Iasonas Kokkinos

Diffusion MRI (dMRI) provides a distinctive means to probe the microstructural architecture of living tissue, facilitating applications such as brain connectivity analysis, modeling across multiple conditions, and the estimation of…

Image and Video Processing · Electrical Eng. & Systems 2025-11-20 Jongyeon Yoon , Elyssa M. McMaster , Michael E. Kim , Gaurav Rudravaram , Kurt G. Schilling , Bennett A. Landman , Daniel Moyer

Convolutional neural networks (CNNs) have shown great effectiveness in medical image segmentation. However, they may be limited in modeling large inter-subject variations in organ shapes and sizes and exploiting global long-range contextual…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Jin Yang , Daniel S. Marcus , Aristeidis Sotiras

Diffusion tensor imaging provides important information on tissue structure and orientation of fiber tracts in brain white matter in vivo. It results in diffusion tensors, which are $3\times3$ symmetric positive definite (SPD) matrices,…

Applications · Statistics 2013-04-17 Ying Yuan , Hongtu Zhu , Martin Styner , John H. Gilmore , J. S. Marron

Fiber tractography on diffusion imaging data offers rich potential for describing white matter pathways in the human brain, but characterizing the spatial organization in these large and complex data sets remains a challenge. We show that…

Methodology · Statistics 2015-06-18 Brian P. Kent , Alessandro Rinaldo , Fang-Cheng Yeh , Timothy Verstynen

Accurate segmentation of the stroke lesions using magnetic resonance imaging (MRI) is associated with difficulties due to the complicated anatomy of the brain and the different properties of the lesions. This study introduces the…

Image and Video Processing · Electrical Eng. & Systems 2024-06-11 Muhammad Nouman , Mohamed Mabrok , Essam A. Rashed

Diffusion-weighted (DW) magnetic resonance imaging is essential for the diagnosis and treatment of ischemic stroke. DW images (DWIs) are usually acquired in multi-slice settings where lesion areas in two consecutive 2D slices are highly…

Image and Video Processing · Electrical Eng. & Systems 2023-05-31 Yanglan Ou , Ye Yuan , Xiaolei Huang , Kelvin Wong , John Volpi , James Z. Wang , Stephen T. C. Wong

Deep learning algorithms have accounted for the rapid acceleration of research in artificial intelligence in medical image analysis, interpretation, and segmentation with many potential applications across various sub disciplines in…

Image and Video Processing · Electrical Eng. & Systems 2020-12-23 Shanaka Ramesh Gunasekara , HNTK Kaldera , Maheshi B. Dissanayake

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…

Accurate and reliable image segmentation is an essential part of biomedical image analysis. In this paper, we consider the problem of biomedical image segmentation using deep convolutional neural networks. We propose a new end-to-end…

Computer Vision and Pattern Recognition · Computer Science 2018-10-02 Amirhossein Dadashzadeh , Alireza Tavakoli Targhi

The differential diagnosis of neurodegenerative diseases, characterized by overlapping symptoms, may be challenging. Brain imaging coupled with artificial intelligence has been previously proposed for diagnostic support, but most of these…

Image and Video Processing · Electrical Eng. & Systems 2025-02-21 Pierrick Coupé , Boris Mansencal , José V. Manjón , Patrice Péran , Wassilios G. Meissner , Thomas Tourdias , Vincent Planche

Brain segmentation is a fundamental first step in neuroimage analysis. In the case of fetal MRI, it is particularly challenging and important due to the arbitrary orientation of the fetus, organs that surround the fetal head, and…

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial method for white matter (WM) parcellation to enable analysis of brains structural connectivity in health and disease. Current fiber clustering strategies primarily use…

Image and Video Processing · Electrical Eng. & Systems 2025-11-04 Bocheng Guo , Jin Wang , Yijie Li , Junyi Wang , Mingyu Gao , Puming Feng , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

A major challenge in stroke research and stroke recovery predictions is the determination of a stroke lesion's extent and its impact on relevant brain systems. Manual segmentation of stroke lesions from 3D magnetic resonance (MR) imaging…

Image and Video Processing · Electrical Eng. & Systems 2023-06-21 Sovesh Mohapatra , Advait Gosai , Anant Shinde , Aleksei Rutkovskii , Sirisha Nouduri , Gottfried Schlaug

Precise 3D segmentation of infant brain tissues is an essential step towards comprehensive volumetric studies and quantitative analysis of early brain developement. However, computing such segmentations is very challenging, especially for…

Computer Vision and Pattern Recognition · Computer Science 2017-12-20 Jose Dolz , Christian Desrosiers , Li Wang , Jing Yuan , Dinggang Shen , Ismail Ben Ayed

Brain imaging studies have demonstrated that diffusion MRI tractography geometric shape descriptors can inform the study of the brain's white matter pathways and their relationship to brain function. In this work, we investigate the…

Computer Vision and Pattern Recognition · Computer Science 2025-02-17 Yui Lo , Yuqian Chen , Dongnan Liu , Jon Haitz Legarreta , Leo Zekelman , Fan Zhang , Jarrett Rushmore , Yogesh Rathi , Nikos Makris , Alexandra J. Golby , Weidong Cai , Lauren J. O'Donnell

In this paper, we demonstrate the feasibility and performance of deep residual neural networks for volumetric segmentation of irreversibly damaged brain tissue lesions on T1-weighted MRI scans for chronic stroke patients. A total of 239…

Image and Video Processing · Electrical Eng. & Systems 2019-11-27 Naofumi Tomita , Steven Jiang , Matthew E. Maeder , Saeed Hassanpour

Reconstructing neuron morphology from 3D light microscope imaging data is critical to aid neuroscientists in analyzing brain networks and neuroanatomy. With the boost from deep learning techniques, a variety of learning-based segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-02-18 Yik San Cheng , Runkai Zhao , Heng Wang , Hanchuan Peng , Yui Lo , Yuqian Chen , Lauren J. O'Donnell , Weidong Cai

Here we present a method for the simultaneous segmentation of white matter lesions and normal-appearing neuroanatomical structures from multi-contrast brain MRI scans of multiple sclerosis patients. The method integrates a novel model for…

Image and Video Processing · Electrical Eng. & Systems 2020-11-26 Stefano Cerri , Oula Puonti , Dominik S. Meier , Jens Wuerfel , Mark Mühlau , Hartwig R. Siebner , Koen Van Leemput

Reconstructing multiple molecularly defined neurons from individual brains and across multiple brain regions can reveal organizational principles of the nervous system. However, high resolution imaging of the whole brain is a technically…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 James Gornet , Kannan Umadevi Venkataraju , Arun Narasimhan , Nicholas Turner , Kisuk Lee , H. Sebastian Seung , Pavel Osten , Uygar Sümbül