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Stabilizing proteins is a foundational step in protein engineering. However, the evolutionary pressure of all extant proteins makes identifying the scarce number of mutations that will improve thermodynamic stability challenging. Deep…

Biomolecules · Quantitative Biology 2023-11-01 Jeffrey Ouyang-Zhang , Daniel J. Diaz , Adam R. Klivans , Philipp Krähenbühl

In recent years, Automated Program Repair (APR) techniques specifically designed for quantum programs have been proposed. However, existing approaches often suffer from low repair success rates or poor understandability of the generated…

Software Engineering · Computer Science 2026-01-21 Chihiro Yoshida , Yuta Ishimoto , Olivier Nourry , Masanari Kondo , Makoto Matsushita , Yasutaka Kamei , Yoshiki Higo

Multi-token prediction (MTP) is a prominent strategy to significantly speed up generation in large language models (LLMs), including byte-level LLMs, which are tokeniser-free but prohibitively slow. However, existing MTP methods often…

Mutation testing is a widely recognized technique for assessing and enhancing the effectiveness of software test suites by introducing deliberate code mutations. However, its application often results in overly large test suites, as…

Software Engineering · Computer Science 2025-05-12 Mohamed Salah Bouafif , Mohammad Hamdaqa , Edward Zulkoski

Confidence estimation aims to quantify the confidence of the model prediction, providing an expectation of success. A well-calibrated confidence estimate enables accurate failure prediction and proper risk measurement when given noisy…

Computation and Language · Computer Science 2022-03-23 Yu Lu , Jiali Zeng , Jiajun Zhang , Shuangzhi Wu , Mu Li

Machine learning (ML) systems are increasingly deployed in high-stakes domains where reliability is paramount. This thesis investigates how uncertainty estimation can enhance the safety and trustworthiness of ML, focusing on selective…

Machine Learning · Computer Science 2025-09-09 Stephan Rabanser

Higher-order mutation has the potential for improving major drawbacks of traditional first-order mutation, such as by simulating more realistic faults or improving test optimization techniques. Despite interest in studying promising…

Software Engineering · Computer Science 2020-04-07 Chu-Pan Wong , Jens Meinicke , Leo Chen , João P. Diniz , Christian Kästner , Eduardo Figueiredo

Mutation testing is the state-of-the-art technique for assessing the fault detection capacity of a test suite. Unfortunately, a full mutation analysis is often prohibitively expensive. The CppCheck project for instance, demands a build time…

Software Engineering · Computer Science 2022-11-01 Sten Vercammen , Serge Demeyer , Markus Borg , Niklas Pettersson , Görel Hedin

Quantum process tomography is an experimental technique to fully characterize an unknown quantum process. Standard quantum process tomography suffers from exponentially scaling of the number of measurements with the increasing system size.…

Quantum Physics · Physics 2022-08-02 Shichuan Xue , Yong Liu , Yang Wang , Pingyu Zhu , Chu Guo , Junjie Wu

If a Micro Processor Unit (MPU) receives an external electric signal as noise, the system function will freeze or malfunction easily. A new resilience strategy is implemented in order to reset the MPU automatically and stop the MPU from…

Software Engineering · Computer Science 2014-05-08 Ling Fang , Yoriyuki Yamagata , Yutaka Oiwa

It is crucial that smart contracts are tested thoroughly due to their immutable nature. Even small bugs in smart contracts can lead to huge monetary losses. However, testing is not enough; it is also important to ensure the quality and…

Software Engineering · Computer Science 2020-01-23 Pieter Hartel , Richard Schumi

Building a good speech recognition system usually requires large amounts of transcribed data, which is expensive to collect. To tackle this problem, many unsupervised pre-training methods have been proposed. Among these methods, Masked…

Audio and Speech Processing · Electrical Eng. & Systems 2020-06-24 Dongwei Jiang , Wubo Li , Ruixiong Zhang , Miao Cao , Ne Luo , Yang Han , Wei Zou , Xiangang Li

Machine unlearning (MU) aims to remove the influence of certain data points from a trained model without costly retraining. Most practical MU algorithms are only approximate and their performance can only be assessed empirically. Care must…

Machine Learning · Computer Science 2026-01-01 Jamie Lanyon , Axel Finke , Petros Andreou , Georgina Cosma

Low-frequency word prediction remains a challenge in modern neural machine translation (NMT) systems. Recent adaptive training methods promote the output of infrequent words by emphasizing their weights in the overall training objectives.…

Computation and Language · Computer Science 2021-12-30 Tong Zhang , Wei Ye , Baosong Yang , Long Zhang , Xingzhang Ren , Dayiheng Liu , Jinan Sun , Shikun Zhang , Haibo Zhang , Wen Zhao

The deep learning approach to detecting malicious software (malware) is promising but has yet to tackle the problem of dataset shift, namely that the joint distribution of examples and their labels associated with the test set is different…

Cryptography and Security · Computer Science 2021-12-15 Deqiang Li , Tian Qiu , Shuo Chen , Qianmu Li , Shouhuai Xu

Machine translation (MT) encompasses a variety of methodologies aimed at enhancing the accuracy of translations. In contrast, the process of human-generated translation relies on a wide range of translation techniques, which are crucial for…

Computation and Language · Computer Science 2024-12-13 Fan Zhou , Vincent Vandeghinste

Benefiting from prompt tuning, recent years have witnessed the promising performance of pre-trained vision-language models, e.g., CLIP, on versatile downstream tasks. In this paper, we focus on a particular setting of learning adaptive…

Computer Vision and Pattern Recognition · Computer Science 2023-08-21 Chun-Mei Feng , Kai Yu , Yong Liu , Salman Khan , Wangmeng Zuo

As the pre-trained language models (PLMs) continue to grow, so do the hardware and data requirements for fine-tuning PLMs. Therefore, the researchers have come up with a lighter method called \textit{Prompt Learning}. However, during the…

Computation and Language · Computer Science 2022-09-07 Yundi Shi , Piji Li , Changchun Yin , Zhaoyang Han , Lu Zhou , Zhe Liu

It is widely believed that the prediction accuracy of decision tree models is invariant under any strictly monotone transformation of the individual predictor variables. However, this statement may be false when predicting new observations…

Machine Learning · Statistics 2016-11-16 Tal Galili , Isaac Meilijson

ProBoost, a new boosting algorithm for probabilistic classifiers, is proposed in this work. This algorithm uses the epistemic uncertainty of each training sample to determine the most challenging/uncertain ones; the relevance of these…

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