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De novo therapeutic design is challenged by a vast chemical repertoire and multiple constraints, e.g., high broad-spectrum potency and low toxicity. We propose CLaSS (Controlled Latent attribute Space Sampling) - an efficient computational…

This work presents twelve fine-tuned deep learning architectures to solve the bacterial classification problem over the Digital Image of Bacterial Species Dataset. The base architectures were mainly published as mobile or efficient…

Computer Vision and Pattern Recognition · Computer Science 2021-06-14 R. Gallardo García , S. Jarquín Rodríguez , B. Beltrán Martínez , C. Hernández Gracidas , R. Martínez Torres

Currently, every 1 in 54 children have been diagnosed with Autism Spectrum Disorder (ASD), which is 178% higher than it was in 2000. An early diagnosis and treatment can significantly increase the chances of going off the spectrum and…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Spencer He , Ryan Liu

Accelerating imaging speed in optical microscopy is often realized at the expense of image contrast, image resolution, and detection sensitivity- a common predicament for advancing high-speed and high-throughput cellular imaging. We here…

We present a rapid and stain-free quantitative viral plaque assay using lensfree holographic imaging and deep learning. This cost-effective, compact, and automated device significantly reduces the incubation time needed for traditional…

We propose a hybrid sequential deep learning model to predict the risk of AMD progression in non-exudative AMD eyes at multiple timepoints, starting from short-term progression (3-months) up to long-term progression (21-months). Proposed…

Quantitative Methods · Quantitative Biology 2019-03-01 Imon Banerjee , Luis de Sisternes , Joelle Hallak , Theodore Leng , Aaron Osborne , Mary Durbin , Daniel Rubin

In assessing the severity of age-related macular degeneration (AMD), the Age-Related Eye Disease Study (AREDS) Simplified Severity Scale predicts the risk of progression to late AMD. However, its manual use requires the time-consuming…

Computer Vision and Pattern Recognition · Computer Science 2019-01-29 Yifan Peng , Shazia Dharssi , Qingyu Chen , Tiarnan D. Keenan , Elvira Agrón , Wai T. Wong , Emily Y. Chew , Zhiyong Lu

Microaneurysms (MAs) are one of the earliest signs of diabetic retinopathy (DR), a frequent complication of diabetes that can lead to visual impairment and blindness. Adaptive optics scanning laser ophthalmoscopy (AOSLO) provides real-time…

Image and Video Processing · Electrical Eng. & Systems 2021-06-29 Qian Zhang , Konstantina Sampani , Mengjia Xu , Shengze Cai , Yixiang Deng , He Li , Jennifer K. Sun , George Em Karniadakis

Diabetic retinopathy (DR) screening is instrumental in preventing blindness, but faces a scaling challenge as the number of diabetic patients rises. Risk stratification for the development of DR may help optimize screening intervals to…

Deep learning models have been successfully used in medical image analysis problems but they require a large amount of labeled images to obtain good performance.Deep learning models have been successfully used in medical image analysis…

Computer Vision and Pattern Recognition · Computer Science 2018-10-02 Asim Smailagic , Hae Young Noh , Pedro Costa , Devesh Walawalkar , Kartik Khandelwal , Mostafa Mirshekari , Jonathon Fagert , Adrián Galdrán , Susu Xu

Low-dose CT (LDCT) protocols reduce radiation exposure but increase image noise, compromising diagnostic confidence. Diffusion-based generative models have shown promise for LDCT denoising by learning image priors and performing iterative…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Tomás de la Sotta , José M. Saavedra , Héctor Henríquez , Violeta Chang , Aline Xavier

Purpose To develop a computer based method for the automated assessment of image quality in the context of diabetic retinopathy (DR) to guide the photographer. Methods A deep learning framework was trained to grade the images automatically.…

Computer Vision and Pattern Recognition · Computer Science 2017-03-08 Sajib Kumar Saha , Basura Fernando , Jorge Cuadros , Di Xiao , Yogesan Kanagasingam

Early detection of diabetic retinopathy (DR) is crucial as it allows for timely intervention, preventing vision loss and enabling effective management of diabetic complications. This research performs detection of DR and DME at an early…

Image and Video Processing · Electrical Eng. & Systems 2025-09-30 Pranoti Nage , Sanjay Shitole

The Auto-ICell system, a novel, and cost-effective integrated droplet microfluidic system, is introduced for real-time analysis of single-cell morphology and apoptosis. This system integrates a 3D-printed microfluidic chip with image…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Yuanyuan Wei , Meiai Lin , Shanhang Luo , Syed Muhammad Tariq Abbasi , Liwei Tan , Guangyao Cheng , Bijie Bai , Yi-Ping Ho , Scott Wu Yuan , Ho-Pui Ho

Automated recognition and classification of bacteria species from microscopic images have significant importance in clinical microbiology. Bacteria classification is usually carried out manually by biologists using different shapes and…

Quantitative Methods · Quantitative Biology 2019-12-19 Muhammed Talo

Biological datasets amenable to applied machine learning are more available today than ever before, yet they lack adequate representation in the Data-for-Good community. Here we present a work in progress case study performing analysis on…

Machine Learning · Statistics 2016-07-06 John W. Santerre , James J. Davis , Fangfang Xia , Rick Stevens

An efficient method is reported for rapid identification of bacterial or mycobacterial infection in a suspected clinical/biological sample. The method is based on the fact that the ring methylene protons of cyclic fatty acids (constituting…

Biological Physics · Physics 2014-12-30 Anupam Guleria , Nitin K Bajpai , Atul Rawat , C L Khetrapal , Narayan Prasad , Dinesh Kumar

Fecal-contaminated water causes diseases and even death. Current microbial water safety tests require pathogen incubation, taking 24-72 hours and costing \$20-\$50 per test. This paper presents a solution (DeepScope) exceeding UNICEF's…

Other Computer Science · Computer Science 2026-03-10 Sanjay Srinivasan

Developing rapid methods for pathogen detection and growth monitoring at low cell and analyte concentrations is an important goal, which numerous technologies are working towards solving. Rapid biosensors have already made a dramatic impact…