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Active search is a learning paradigm for actively identifying as many members of a given class as possible. A critical target scenario is high-throughput screening for scientific discovery, such as drug or materials discovery. In this…

Machine Learning · Computer Science 2018-11-27 Shali Jiang , Gustavo Malkomes , Benjamin Moseley , Roman Garnett

Experiments in engineering are typically conducted in controlled environments where parameters can be set to any desired value. This assumes that the same applies in a real-world setting -- an assumption that is often incorrect as many…

Machine Learning · Computer Science 2025-11-18 Mike Diessner , Kevin J. Wilson , Richard D. Whalley

Epidemiological models are an important tool in coping with epidemics, as they offer a forecast, even if often simplistic, of the behavior of the disease in the population. This allows responsible health agencies to organize themselves and…

Populations and Evolution · Quantitative Biology 2023-08-03 Eliza Maria Ferreira , Ricardo Edem Ferreira , Chiara Mocenni

Social distancing strategies have been adopted by governments to manage the COVID-19 pandemic, since the first outbreak began. However, further epidemic waves keep out the return of economic and social activities to their standard levels of…

Optimization and Control · Mathematics 2021-06-07 J. E. Sereno , A. D' Jorge , A. Ferramosca , E. A. Hernandez-Vargas , A. H. Gonzalez

We study the impact of parameter estimation and state measurement errors on a control framework for optimally mitigating the spread of epidemics. We capture the epidemic spreading process using a susceptible-infected-removed (SIR) epidemic…

Systems and Control · Electrical Eng. & Systems 2024-08-08 Baike She , Lei Xin , Shreyas Sundaram , Philip E. Paré

Stochastic process discovery is concerned with deriving a model capable of reproducing the stochastic character of observed executions of a given process, stored in a log. This leads to an optimisation problem in which the model's parameter…

Formal Languages and Automata Theory · Computer Science 2025-05-01 Pierre Cry , Paolo Ballarini , András Horváth , Pascale Le Gall

The outbreak of coronavirus disease (COVID-19) has swept across more than 180 countries and territories since late January 2020. As a worldwide emergency response, governments have implemented various measures and policies, such as…

Human-Computer Interaction · Computer Science 2022-05-03 Chuang Yang , Zhiwen Zhang , Zipei Fan , Renhe Jiang , Quanjun Chen , Xuan Song , Ryosuke Shibasaki

It is challenging for reinforcement learning (RL) algorithms to succeed in real-world applications like financial trading and logistic system due to the noisy observation and environment shifting between training and evaluation. Thus, it…

Machine Learning · Computer Science 2022-05-20 Zhengyu Yang , Kan Ren , Xufang Luo , Minghuan Liu , Weiqing Liu , Jiang Bian , Weinan Zhang , Dongsheng Li

Bayesian optimization has proven to be a highly effective methodology for the global optimization of unknown, expensive and multimodal functions. The ability to accurately model distributions over functions is critical to the effectiveness…

Machine Learning · Statistics 2014-06-13 Jasper Snoek , Kevin Swersky , Richard S. Zemel , Ryan P. Adams

This paper analyses the optimal control of infectious disease propagation using a classic susceptible-infected-recovered (SIR) model characterised by permanent immunity and the absence of available vaccines. The control is performed over a…

Optimization and Control · Mathematics 2024-06-12 Rocío Balderrama , Mariana Inés Prieto , Constanza Sánchez de la Vega , Federico Vazquez

Reinforcement learning (RL) has achieved promising results on most robotic control tasks. Safety of learning-based controllers is an essential notion of ensuring the effectiveness of the controllers. Current methods adopt whole consistency…

Robotics · Computer Science 2023-07-31 Haotian Xu , Shengjie Wang , Zhaolei Wang , Yunzhe Zhang , Qing Zhuo , Yang Gao , Tao Zhang

On 19th March, the World Health Organisation declared a pandemic. Through this global spread, many nations have witnessed exponential growth of confirmed cases brought under control by severe mass quarantine or lockdown measures. However,…

Other Quantitative Biology · Quantitative Biology 2022-09-28 Annalisa Riccardi , Jessica Gemignani , Francisco Fernández-Navarro , Anna Heffernan

Bayesian optimization is a methodology for global optimization of unknown and expensive objectives. It combines a surrogate Bayesian regression model with an acquisition function to decide where to evaluate the objective. Typical regression…

Machine Learning · Computer Science 2023-04-04 Afonso Eduardo , Michael U. Gutmann

We analyze an optimal control version of a simple SIR epidemiology model that includes a partially specified vaccination policy and takes into account fatigue from protracted application of social distancing measures. The model assumes…

Populations and Evolution · Quantitative Biology 2021-08-17 Evangelos F. Magirou

Bayesian optimisation has been successfully applied to a variety of reinforcement learning problems. However, the traditional approach for learning optimal policies in simulators does not utilise the opportunity to improve learning by…

We consider the low-prevalence linearized SEIR epidemic model for a society that has resolved to keep future infections low in anticipation of a vaccine. The society can vary its amount of potentially-infection-spreading activity over time,…

Optimization and Control · Mathematics 2020-09-17 Scott Sheffield

Bayesian Optimization (BO) is an effective method for optimizing expensive-to-evaluate black-box functions with a wide range of applications for example in robotics, system design and parameter optimization. However, scaling BO to problems…

Systems and Control · Electrical Eng. & Systems 2020-01-22 Lukas P. Fröhlich , Edgar D. Klenske , Christian G. Daniel , Melanie N. Zeilinger

The paper addresses the question of lives versus livelihood in an SIRD model augmented with a macroeconomic structure. The constraints on the availability of health facilities - both infrastructure and health workers determine the…

Dynamical Systems · Mathematics 2021-09-07 Gopal K. Basak , Chandramauli Chakraborty , Pranab Kumar Das

Nonclassical correlations provide a resource for many applications in quantum technology as well as providing strong evidence that a system is indeed operating in the quantum regime. Optomechanical systems can be arranged to generate…

Lately, concepts such as lockdown, quarantine, and social distancing have become very relevant since they have been associated with essential measures in the prevention and mitigation of COVID-19. While some conclusions about the…

Physics and Society · Physics 2023-04-04 Eric Rozan , Sebastian Bouzat , Marcelo N Kuperman