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The recent global pandemic of Coronavirus Disease 2019 (COVID-19) caused by the new coronavirus SARS-CoV-2 presents an urgent need for new therapeutic candidates. Many efforts have been devoted to screening existing drug libraries with the…

Quantitative Methods · Quantitative Biology 2020-07-27 Hu Zhu , Catherine Z. Chen , Srilatha Sakamuru , Anton Simeonov , Mathew D. Hall , Menghang Xia , Wei Zheng , Ruili Huang

COVID-19, the disease caused by the SARS-CoV-2 virus, has been declared a pandemic by the World Health Organization, which has reported over 18 million confirmed cases as of August 5, 2020. In this review, we present an overview of recent…

Computers and Society · Computer Science 2021-01-12 Joseph Bullock , Alexandra Luccioni , Katherine Hoffmann Pham , Cynthia Sin Nga Lam , Miguel Luengo-Oroz

The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no effective antiviral drug except treatments for symptomatic therapy. Flux balance analysis is an efficient method to analyze metabolic networks. It allows…

Molecular Networks · Quantitative Biology 2021-11-12 Ali Kishk , Maria Pires Pacheco , Thomas Sauter

A new coronavirus identified as SARS-CoV-2 virus has brought the world to a state of crisis, causing a major pandemic, claiming more than 433,000 lives and instigating major financial damage to the global economy. Despite current efforts,…

Biomolecules · Quantitative Biology 2020-06-18 Mohsen Chitsaz

The COVID-19 crisis called for rapid reaction from all the fields of biomedical research. Traditional drug development involves time consuming pipelines that conflict with the urgence of identifying effective therapies during a health and…

Genomics · Quantitative Biology 2020-05-06 Francesco Napolitano , Gennaro Gambardella , Diego Carrella , Xin Gao , Diego di Bernardo

The world has faced the devastating outbreak of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), or COVID-19, in 2020. Research in the subject matter was fast-tracked to such a point that scientists were struggling to keep up…

Information Retrieval · Computer Science 2020-09-03 Maksim Ekin Eren , Nick Solovyev , Edward Raff , Charles Nicholas , Ben Johnson

Very recently the new pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified and the coronavirus disease 2019 (COVID-19) declared a pandemic by the World Health Organization. The pandemic has a number of…

The COVID-19 pandemic has initiated a global health emergency, with an exigent need for effective cure. Progressively, drug repurposing is emerging a promise solution as it saves the time, cost and labor. However, the number of drug…

Biomolecules · Quantitative Biology 2024-06-25 Imra Aqeel , Abdul Majid

Given the severity of the SARS-CoV-2 pandemic, a major challenge is to rapidly repurpose existing approved drugs for clinical interventions. While a number of data-driven and experimental approaches have been suggested in the context of…

The deadly coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gone out of control globally. Despite much effort by scientists, medical experts, and society in general, the…

Biomolecules · Quantitative Biology 2021-02-02 Kaifu Gao , Rui Wang , Jiahui Chen , Limei Cheng , Jaclyn Frishcosy , Yuta Huzumi , Yuchi Qiu , Tom Schluckbier , Guo-Wei Wei

The COVID-19 (coronavirus) is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus was first identified in mid-December 2019 in the Hubei province of Wuhan, China and by now has spread…

Image and Video Processing · Electrical Eng. & Systems 2022-01-26 Aditya Saxena , Shamsheer Pal Singh

The outbreak of the novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been continuously affecting human lives and communities around the world in many ways, from cities…

Machine Learning · Computer Science 2020-07-24 Ashkan Ebadi , Pengcheng Xi , Stéphane Tremblay , Bruce Spencer , Raman Pall , Alexander Wong

During 2020 and 2021, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission has been increasing amongst the world's population at an alarming rate. Reducing the spread of SARS-CoV-2 and other diseases that are spread in…

Social and Information Networks · Computer Science 2022-03-22 Patrick Urrutia , David Wren , Chrysafis Vogiatzis , Ruriko Yoshida

There remains an urgent need to identify existing drugs that might be suitable for treating patients suffering from COVID-19 infection. Drugs rarely act at a single molecular target, with off target effects often being responsible for…

Biomolecules · Quantitative Biology 2020-09-03 Sakshi Piplani , Puneet Singh , Nikolai Petrovsky , David A. Winkler

The discovery of SARS-CoV-2, the responsible virus for the Covid-19 epidemic, has sparked a global health concern with many countries affected. Developing models that can interpret the epidemic and give common trend parameters are useful…

Populations and Evolution · Quantitative Biology 2021-09-21 Milad Radiom , Jean-Franccois Berret

Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2). The virus transmits rapidly; it has a basic reproductive number R of 2.2-2.7. In March 2020, the World Health Organization…

Image and Video Processing · Electrical Eng. & Systems 2021-07-02 Vishal Sharma , Curtis Dyreson

Global coronavirus disease pandemic (COVID-19) caused by newly identified SARS- CoV-2 coronavirus continues to claim the lives of thousands of people worldwide. The unavailability of specific medications to treat COVID-19 has led to drug…

Quantitative Methods · Quantitative Biology 2020-06-12 Romeo Cozac , Nazim Medzhidov , Shinya Yuki

Researchers across the globe are seeking to rapidly repurpose existing drugs or discover new drugs to counter the the novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One promising…

The COVID-19 pandemic caused by the SARS-CoV-2 virus has spread rapidly worldwide, leading to a global outbreak. Most governments, enterprises, and scientific research institutions are participating in the COVID-19 struggle to curb the…

Quantitative Methods · Quantitative Biology 2021-03-12 Jianguo Chen , Kenli Li , Zhaolei Zhang , Keqin Li , Philip S. Yu

Researchers worldwide are seeking to repurpose existing drugs or discover new drugs to counter the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A promising source of candidates for such studies is…

Computation and Language · Computer Science 2021-01-13 Zhi Hong , J. Gregory Pauloski , Logan Ward , Kyle Chard , Ben Blaiszik , Ian Foster