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There is increasing interest in comparing institutions delivering healthcare in terms of disease-specific quality indicators (QIs) that capture processes or outcomes showing variations in the care provided. Such comparisons can be framed in…

Methodology · Statistics 2020-09-07 Bo Chen , Keith A. Lawson , Antonio Finelli , Olli Saarela

Causal variance decompositions for a given disease-specific quality indicator can be used to quantify differences in performance between hospitals or health care providers. While variance decompositions can demonstrate variation in quality…

Methodology · Statistics 2023-01-26 Bo Chen , Keith A. Lawson , Antonio Finelli , Olli Saarela

Recent causal inference literature has introduced causal effect decompositions to quantify sources of observed inequalities or disparities in outcomes, but these approaches are typically limited to pairwise comparisons. In healthcare…

Methodology · Statistics 2026-04-27 Lin Yu , Zhihui Liu , Kathy Han , Olli Saarela

Assessing the quality of cancer care administered by US health providers poses numerous challenges due to meaningful heterogeneity in patient populations. Patients undergoing oncology treatment exhibit substantial variation in disease…

Applications · Statistics 2025-02-17 Yige Li , Nancy L. Keating , Mary Beth Landrum , Jose R. Zubizarreta

A causal decomposition analysis allows researchers to determine whether the difference in a health outcome between two groups can be attributed to a difference in each group's distribution of one or more modifiable mediator variables. With…

Methodology · Statistics 2024-08-09 Melissa J. Smith , Leslie A. McClure , D. Leann Long

We analyze large, multi-dimensional, sparse counting data sets, finding unsupervised groups to provide unique insights into genetic data. We create gene and biological pathway groups based on patients' variants to find common risk factors…

Machine Learning · Computer Science 2025-09-01 Adam Sandler , Diego Klabjan , Yuan Luo

Scientists often want to learn about cause and effect from hierarchical data, collected from subunits nested inside units. Consider students in schools, cells in patients, or cities in states. In such settings, unit-level variables (e.g.…

Methodology · Statistics 2024-06-27 Eli N. Weinstein , David M. Blei

This paper introduces a novel decomposition framework to explain heterogeneity in causal effects observed across different studies, considering both observational and randomized settings. We present a formal decomposition of between-study…

Methodology · Statistics 2025-12-18 Brian Gilbert , Ivan Dıaz , Kara E. Rudolph , Nicholas Williams , Tat-Thang Vo

Causal decomposition analyses can help build the evidence base for interventions that address health disparities (inequities). They ask how disparities in outcomes may change under hypothetical intervention. Through study design and…

Methodology · Statistics 2020-09-17 John W. Jackson

Background: Quality indicators are frequently used to assess the performance of healthcare providers, in particular hospitals. Established approaches to the design of such indicators are subject to distortions due to indirect…

Applications · Statistics 2022-06-28 Martin Roessler , Claudia Schulte , Uwe Repschläger , Dagmar Hertle , Danny Wende

Healthcare artificial intelligence systems often degrade in performance when deployed across institutions, with documented performance drops and perpetuation of discriminatory patterns embedded in data. This brittleness comes, in part, from…

Machine Learning · Computer Science 2026-03-30 Munib Mesinovic , Max Buhlan , Tingting Zhu

The quality of healthcare provided by hospitals is subject to considerable variability. Consequently, accurate measurements of hospital performance are essential for various decision-makers, including patients, hospital managers and health…

Applications · Statistics 2020-11-16 Eva van Weenen , Stefan Feuerriegel

A popular method for estimating a causal treatment effect with observational data is the difference-in-differences (DiD) model. In this work, we consider an extension of the classical DiD setting to the hierarchical context in which data…

Methodology · Statistics 2019-10-17 James Normington , Eric F. Lock , Thomas A. Murray , Caroline S. Carlin

Understanding treatment effect heterogeneity is vital for scientific and policy research. However, identifying and evaluating heterogeneous treatment effects pose significant challenges due to the typically unknown subgroup structure.…

Methodology · Statistics 2024-11-05 Kwangho Kim , Jisu Kim , Larry A. Wasserman , Edward H. Kennedy

Inference about treatment effects for time-to-event outcomes is often obscured by the presence of competing events. A particularly complex situation arises when the treatment influences the occurrence of the competing event. A comprehensive…

Clustering can be used to extract insights from data or to verify some of the assumptions held by the domain experts, namely data segmentation. In the literature, few methods can be applied in clustering qualitative values using the context…

Machine Learning · Computer Science 2020-07-07 Diogo Seca , João Mendes-Moreira , Tiago Mendes-Neves , Ricardo Sousa

In a randomised clinical trial, when the result of the primary endpoint shows a significant benefit, the secondary endpoints are scrutinised to identify additional effects of the treatment. However, this approach entails a risk of…

Monitoring outcomes of health care providers, such as patient deaths, hospitalizations and hospital readmissions, helps in assessing the quality of health care. We consider a large database on patients being treated at dialysis facilities…

Applications · Statistics 2020-06-24 Lu Xia , Kevin He , Yanming Li , John D. Kalbfleisch

In this paper we study the problems of estimating heterogeneity in causal effects in experimental or observational studies and conducting inference about the magnitude of the differences in treatment effects across subsets of the…

Machine Learning · Statistics 2022-06-08 Susan Athey , Guido Imbens

Medical AI algorithms can often experience degraded performance when evaluated on previously unseen sites. Addressing cross-site performance disparities is key to ensuring that AI is equitable and effective when deployed on diverse patient…

Machine Learning · Computer Science 2021-11-17 Eric Wu , Kevin Wu , James Zou
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