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The National Health and Nutrition Examination Survey (NHANES) studies the nutritional and health status over the whole U.S. population with comprehensive physical examinations and questionnaires. However, survey data analyses become…

Methodology · Statistics 2019-08-06 Xiaojun Mao , Zhonglei Wang , Shu Yang

Multi-view clustering (MVC), which effectively fuses information from multiple views for better performance, has received increasing attention. Most existing MVC methods assume that multi-view data are fully paired, which means that the…

Machine Learning · Computer Science 2023-07-10 Yi Wen , Siwei Wang , Qing Liao , Weixuan Liang , Ke Liang , Xinhang Wan , Xinwang Liu

Computer-aided diagnosis (CADx) systems have been shown to assist radiologists by providing classifications of all kinds of medical images like Computed tomography (CT) and Magnetic resonance (MR). Currently, convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2019-06-06 Yifan Hu , Yefeng Zheng

Completing a data matrix X has become an ubiquitous problem in modern data science, with applications in recommender systems, computer vision, and networks inference, to name a few. One typical assumption is that X is low-rank. A more…

Machine Learning · Computer Science 2018-08-03 Daniel L. Pimentel-Alarcón

Medical generative models, acknowledged for their high-quality sample generation ability, have accelerated the fast growth of medical applications. However, recent works concentrate on separate medical generation models for distinct medical…

Image and Video Processing · Electrical Eng. & Systems 2024-03-08 Chenlu Zhan , Yu Lin , Gaoang Wang , Hongwei Wang , Jian Wu

There has been an increasing interest in using cell and gene therapy (CGT) to treat/cure difficult diseases. The hallmark of CGT trials are the small sample size and extremely high efficacy. Due to the innovation and novelty of such…

Applications · Statistics 2025-10-23 Yaoyuan Vincent Tan , Gang Xu , Chenkun Wang

Chronic diseases such as diabetes pose significant management challenges, particularly due to the risk of complications like hypoglycemia, which require timely detection and intervention. Continuous health monitoring through wearable…

Machine Learning · Computer Science 2026-01-08 Vaibhav Gupta , Florian Grensing , Beyza Cinar , Maria Maleshkova

Medical imaging provides essential visual insights for diagnosis, and multimodal large language models (MLLMs) are increasingly utilized for its analysis due to their strong generalization capabilities; however, the underlying factors…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Zhenyang Cai , Junying Chen , Rongsheng Wang , Weihong Wang , Yonglin Deng , Dingjie Song , Yize Chen , Zixu Zhang , Benyou Wang

In clinical trials, mixed effects models for repeated measures (MMRM) and pattern mixture models (PMM) are often used to analyze longitudinal continuous outcomes. We describe a simple missing data imputation algorithm for the MMRM that can…

Methodology · Statistics 2016-10-13 Yongqiang Tang

Missing values exist in nearly all clinical studies because data for a variable or question are not collected or not available. Inadequate handling of missing values can lead to biased results and loss of statistical power in analysis.…

Machine Learning · Computer Science 2021-03-04 Narges Pourshahrokhi , Samaneh Kouchaki , Kord M. Kober , Christine Miaskowski , Payam Barnaghi

Large vision-language models (LVLMs) have shown great promise in medical applications, particularly in visual question answering (MedVQA) and diagnosis from medical images. However, existing datasets and models often fail to consider…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Linjie Mu , Zhongzhen Huang , Shengqian Qin , Yakun Zhu , Shaoting Zhang , Xiaofan Zhang

Causal discovery algorithms estimate causal graphs from observational data. This can provide a valuable complement to analyses focussing on the causal relation between individual treatment-outcome pairs. Constraint-based causal discovery…

Methodology · Statistics 2021-08-31 Janine Witte , Ronja Foraita , Vanessa Didelez

We study simultaneous inference for multiple matrix-variate Gaussian graphical models in high-dimensional settings. Such models arise when spatiotemporal data are collected across multiple sample groups or experimental sessions, where each…

Methodology · Statistics 2026-01-21 Zongge Liu , Heejong Bong , Zhao Ren , Matthew A. Smith , Robert E. Kass

Large language models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence technology which is rapidly evolving and promises to aid in medical diagnosis. However, the correctness and the accuracy of their returns has…

Computation and Language · Computer Science 2024-02-07 Dimitrios P. Panagoulias , Maria Virvou , George A. Tsihrintzis

Longitudinal studies are frequently used in medical research and involve collecting repeated measures on individuals over time. Observations from the same individual are invariably correlated and thus an analytic approach that accounts for…

The generalized linear mixed model (GLMM) is widely used for analyzing correlated data, particularly in large-scale biomedical and social science applications. Scalable Bayesian inference for GLMMs is challenging because the marginal…

Computation · Statistics 2026-01-07 Samuel I. Berchuck , Youngsoo Baek , Felipe A. Medeiros , Andrea Agazzi

Due to its complexity, graph learning-based multi-modal integration and classification is one of the most challenging obstacles for disease prediction. To effectively offset the negative impact between modalities in the process of…

Machine Learning · Computer Science 2025-02-14 Jin Liu , Junbin Mao , Hanhe Lin , Hulin Kuang , Shirui Pan , Xusheng Wu , Shan Xie , Fei Liu , Yi Pan

The challenge of handling missing data is widespread in modern data analysis, particularly during the preprocessing phase and in various inferential modeling tasks. Although numerous algorithms exist for imputing missing data, the…

Methodology · Statistics 2024-03-28 Marcos Matabuena , Carla Díaz-Louzao , Rahul Ghosal , Francisco Gude

Graph neural networks (GNNs) have emerged as one of the most effective ML techniques for drug effect prediction from drug molecular graphs. Despite having immense potential, GNN models lack performance when using datasets that contain…

Machine Learning · Computer Science 2024-10-15 Avishek Bose , Guojing Cong

Magnetic resonance imaging (MRI) provides detailed soft-tissue characteristics that assist in disease diagnosis and screening. However, the accuracy of clinical practice is often hindered by missing or unusable slices due to various…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Junkai Liu , Nay Aung , Theodoros N. Arvanitis , Stefan K. Piechnik , Joao A C Lima , Steffen E. Petersen , Le Zhang