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This thesis introduces PEMS2, an improvement to PEMS (Parallel External Memory System). PEMS executes Bulk-Synchronous Parallel (BSP) algorithms in an External Memory (EM) context, enabling computation with very large data sets which exceed…

Distributed, Parallel, and Cluster Computing · Computer Science 2010-01-20 David E. Robillard

Machine learning models, and deep neural networks in particular, are increasingly deployed in risk-sensitive domains such as healthcare, environmental forecasting, and finance, where reliable quantification of predictive uncertainty is…

Machine Learning · Computer Science 2026-04-07 Asena Karolin Özdemir , Lars H. Heyen , Arvid Weyrauch , Achim Streit , Markus Götz , Charlotte Debus

Large-scale simulation optimization (SO) problems encompass both large-scale ranking-and-selection problems and high-dimensional discrete or continuous SO problems, presenting significant challenges to existing SO theories and algorithms.…

Optimization and Control · Mathematics 2024-03-26 Weiwei Fan , L. Jeff Hong , Guangxin Jiang , Jun Luo

The phenomena that emerge from the interaction of the stochastic opening and closing of ion channels (channel noise) with the non-linear neural dynamics are essential to our understanding of the operation of the nervous system. The effects…

Neurons and Cognition · Quantitative Biology 2012-05-29 Patricio Orio , Daniel Soudry

Spatial decomposition is a popular basis for parallelising code. Cast in the frame of task parallelism, calculations on a spatial domain can be treated as a task. If neighbouring domains interact and share results, access to the specific…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-01-20 Christoph Niethammer , Colin W. Glass , Jose Gracia

An efficient numerical algorithm is presented for massively parallel simulations of dispersion-managed wavelength-division-multiplexed optical fiber systems. The algorithm is based on a weak nonlinearity approximation and independent…

Pattern Formation and Solitons · Physics 2009-11-07 P. M. Lushnikov

Biological cells can exchange messages through soluble molecules or membrane-bound receptors. In particular in the latter case, the interaction is usually located in specific regions of the interacting cells and may depend on or induce…

Quantitative Methods · Quantitative Biology 2023-12-12 Thorsten Prüstel , Martin Meier-Schellersheim

BioScape is a concurrent language motivated by the biological landscapes found at the interface of biology and biomaterials. It has been motivated by the need to model antibacterial surfaces, biofilm formation, and the effect of DNAse in…

Logic in Computer Science · Computer Science 2012-11-21 Adriana Compagnoni , Mariangiola Dezani-Ciancaglini , Paola Giannini , Karin Sauer , Vishakha Sharma , Angelo Troina

We describe a new algorithm for simulating complex Markoff-processes. We have used a reaction-cell method in order to simulate arbitrary reactions. It can be used for any kind of RDS on arbitrary topologies, including fractal dimensions or…

chem-ph · Physics 2009-10-28 Thomas Fricke , Dietmar Wendt

In an experimental study of single enzyme reactions, it has been proposed that the rate constants of the enzymatic reactions fluctuate randomly, according to a given distribution. To quantify the uncertainty arising from random rate…

Quantitative Methods · Quantitative Biology 2012-02-07 Chia Ying Lee

The Stochastic Approximation EM (SAEM) algorithm, a variant stochastic approximation of EM, is a versatile tool for inference in incomplete data models. In this paper, we review the fundamental EM algorithm and then focus especially on the…

Methodology · Statistics 2018-11-30 Vahid Tadayon

Investigating the dynamics of growing cell populations is crucial for unraveling key biological mechanisms in living organisms, with many important applications in therapeutics and biochemical engineering. Classical agent-based simulation…

Quantitative Methods · Quantitative Biology 2025-01-22 Shaoqing Chen , Zhou Fang , Zheng Hu , Da Zhou

We describe a system that simplifies the process of debugging programs produced by computer-aided parallelization tools. The system uses relative debugging techniques to compare serial and parallel executions in order to show where the…

Software Engineering · Computer Science 2007-05-23 Robert Hood , Gabriele Jost

Asynchronous Bayesian optimization is a recently implemented technique that allows for parallel operation of experimental systems and disjointed workflows. Contrasting with serial Bayesian optimization which individually selects experiments…

Machine Learning · Computer Science 2024-10-23 Amanda A. Volk , Kristofer G. Reyes , Jeffrey G. Ethier , Luke A. Baldwin

In this paper, we propose a new framework for designing fast parallel algorithms for fundamental statistical subset selection tasks that include feature selection and experimental design. Such tasks are known to be weakly submodular and are…

Machine Learning · Computer Science 2021-04-02 Sharon Qian , Yaron Singer

In this work, we have developed a multiscale computational algorithm to couple finite element method with an open source molecular dynamics code --- the Large scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) --- to perform…

Soft Condensed Matter · Physics 2019-09-17 Takahiro Murashima , Shingo Urata , Shaofan Li

In this paper, we focus on activating only a few sensors, among many available, to estimate the state of a stochastic process of interest. This problem is important in applications such as target tracking and simultaneous localization and…

Systems and Control · Computer Science 2016-09-28 Vasileios Tzoumas , Nikolay A. Atanasov , Ali Jadbabaie , George J. Pappas

This paper studies parallelization schemes for stochastic Vector Quantization algorithms in order to obtain time speed-ups using distributed resources. We show that the most intuitive parallelization scheme does not lead to better…

Machine Learning · Statistics 2012-05-14 Matthieu Durut , Benoît Patra , Fabrice Rossi

Cascade SVM (CSVM) can group datasets and train subsets in parallel, which greatly reduces the training time and memory consumption. However, the model accuracy obtained by using this method has some errors compared with direct training. In…

Machine Learning · Computer Science 2022-03-14 Yi Cheng , Liu , XiaoYan , Liu

Stochastic simulation is a widely used method for estimating quantities in models of chemical reaction networks where uncertainty plays a crucial role. However, reducing the statistical uncertainty of the corresponding estimators requires…

Quantitative Methods · Quantitative Biology 2019-06-13 Michael Backenköhler , Luca Bortolussi , Verena Wolf