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By analogy with Monte Carlo algorithms, we propose new strategies for design and redesign of small molecule libraries in high-throughput experimentation, or combinatorial chemistry. Several Monte Carlo methods are examined, including…

Statistical Mechanics · Physics 2007-05-23 Ligang Chen , Michael W. Deem

Monte Carlo sampling is a powerful toolbox of algorithmic techniques widely used for a number of applications wherein some noisy quantity, or summary statistic thereof, is sought to be estimated. In this paper, we survey the literature for…

Evolutionary Algorithms are naturally inspired approximation optimisation algorithms that usually interfere with science problems when common mathematical methods are unable to provide a good solution or finding the exact solution requires…

Artificial Intelligence · Computer Science 2021-02-03 Mohammed ElKomy

Evolutionary algorithms have been used in the digital art scene since the 1970s. A popular application of genetic algorithms is to optimize the procedural placement of vector graphic primitives to resemble a given painting. In recent years,…

Neural and Evolutionary Computing · Computer Science 2022-01-31 Yingtao Tian , David Ha

Natural Evolution Strategies (NES) is a promising framework for black-box continuous optimization problems. NES optimizes the parameters of a probability distribution based on the estimated natural gradient, and one of the key parameters…

Neural and Evolutionary Computing · Computer Science 2022-02-08 Masahiro Nomura , Isao Ono

We develop algorithms capable of tackling robust black-box optimisation problems, where the number of model runs is limited. When a desired solution cannot be implemented exactly the aim is to find a robust one, where the worst case in an…

Optimization and Control · Mathematics 2020-04-17 Martin Hughes , Marc Goerigk , Trivikram Dokka

The art of solving the Mastermind puzzle was initiated by Donald Knuth and is already more than 30 years old; despite that, it still receives much attention in operational research and computer games journals, not to mention the…

Neural and Evolutionary Computing · Computer Science 2009-12-15 Tomas Philip Runarsson , Juan J. Merelo-Guervos

A number of optimization algorithms have been inspired by the physics of Newtonian motion. Here, we ask the question: do algorithms themselves obey some ``natural laws of motion,'' and can they be derived by an application of these laws? We…

Optimization and Control · Mathematics 2026-04-21 I. M. Ross

Recently double-bracket quantum algorithms have been proposed as a way to compile circuits for approximating eigenstates. Physically, they consist of appropriately composing evolutions under an input Hamiltonian together with diagonal…

An analogy between combinatorial chemistry and Monte Carlo computer simulation is pursued. Examples of how to design libraries for both materials discovery and protein molecular evolution are given. For materials discovery, the concept of…

Statistical Mechanics · Physics 2007-05-23 Michael W. Deem

In this note, we extend an evolutionary stochastic portfolio optimization framework to include probabilistic constraints. Both the stochastic programming-based modeling environment as well as the evolutionary optimization environment are…

Portfolio Management · Quantitative Finance 2014-01-21 Ronald Hochreiter

Many scientific and technological problems are related to optimization. Among them, black-box optimization in high-dimensional space is particularly challenging. Recent neural network-based black-box optimization studies have shown…

Neural and Evolutionary Computing · Computer Science 2024-01-30 Changhwi Park

Monte Carlo methods are widely used importance sampling techniques for studying complex physical systems. Integrating these methods with deep learning has significantly improved efficiency and accuracy in high-dimensional problems and…

Disordered Systems and Neural Networks · Physics 2024-12-24 Yixiong Ren , Jianhui Zhou

Quantum algorithms offer the potential for significant computational advantages; however, in many cases, it remains unclear how these advantages can be practically realized. Causal Set Theory is a discrete, Lorentz-invariant approach to…

Quantum Physics · Physics 2025-06-25 Stuart Ferguson , Arad Nasiri , Petros Wallden

Nature is known to be the best optimizer. Natural processes most often than not reach an optimal equilibrium. Scientists have always strived to understand and model such processes.Thus, many algorithms exist today that are inspired by…

Neural and Evolutionary Computing · Computer Science 2019-03-06 Pranshu Gupta

Purpose: In recent years Monte-Carlo sampling methods, such as Monte Carlo tree search, have achieved tremendous success in model free reinforcement learning. A combination of the so called upper confidence bounds policy to preserve the…

Artificial Intelligence · Computer Science 2011-10-24 Boris Mitavskiy , Jonathan Rowe , Chris Cannings

Combinatorial optimization is a promising application for near-term quantum computers, however, identifying performant algorithms suited to noisy quantum hardware remains as an important goal to potentially realizing quantum computational…

Quantum Physics · Physics 2025-04-01 Titus D. Morris , Ananth Kaushik , Martin Roetteler , Phillip C. Lotshaw

Genetic algorithms constitute a family of black-box optimization algorithms, which take inspiration from the principles of biological evolution. While they provide a general-purpose tool for optimization, their particular instantiations can…

Neural and Evolutionary Computing · Computer Science 2023-04-11 Robert Tjarko Lange , Tom Schaul , Yutian Chen , Chris Lu , Tom Zahavy , Valentin Dalibard , Sebastian Flennerhag

This Perspective focuses on the several overlaps between quantum algorithms and Monte Carlo methods in the domains of physics and chemistry. We will analyze the challenges and possibilities of integrating established quantum Monte Carlo…

Quantum Physics · Physics 2024-09-26 Guglielmo Mazzola

Evolutionary algorithms are well suited for solving the knapsack problem. Some empirical studies claim that evolutionary algorithms can produce good solutions to the 0-1 knapsack problem. Nonetheless, few rigorous investigations address the…

Neural and Evolutionary Computing · Computer Science 2014-10-07 Jun He , Boris Mitavskiy , Yuren Zhou