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Molecular similarity search has been widely used in drug discovery to identify structurally similar compounds from large molecular databases rapidly. With the increasing size of chemical libraries, there is growing interest in the efficient…

Hardware Architecture · Computer Science 2021-09-15 Hongwu Peng , Shiyang Chen , Zhepeng Wang , Junhuan Yang , Scott A. Weitze , Tong Geng , Ang Li , Jinbo Bi , Minghu Song , Weiwen Jiang , Hang Liu , Caiwen Ding

The growing demand for efficient, high-performance processing in machine learning (ML) and image processing has made hardware accelerators, such as GPUs and Data Streaming Accelerators (DSAs), increasingly essential. These accelerators…

Hardware Architecture · Computer Science 2025-04-17 Qunyou Liu , Marina Zapater , David Atienza

As machine learning (ML) is increasingly implemented in hardware to address real-time challenges in scientific applications, the development of advanced toolchains has significantly reduced the time required to iterate on various designs.…

Large language models have been widely adopted across different tasks, but their auto-regressive generation nature often leads to inefficient resource utilization during inference. While batching is commonly used to increase throughput,…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-14 Pol G. Recasens , Ferran Agullo , Yue Zhu , Chen Wang , Eun Kyung Lee , Olivier Tardieu , Jordi Torres , Josep Ll. Berral

Graph analytics are vital in fields such as social networks, biomedical research, and graph neural networks (GNNs). However, traditional CPUs and GPUs struggle with the memory bottlenecks caused by large graph datasets and their…

Hardware Architecture · Computer Science 2024-11-25 Oluwole Jaiyeoba , Abdullah T. Mughrabi , Morteza Baradaran , Beenish Gul , Kevin Skadron

The performance of discrete general purpose graphics processing units (GPGPUs) has been improving at a rapid pace. The PCIe interconnect that controls the communication of data between the system host memory and the GPU has not improved as…

Computational Physics · Physics 2019-05-15 Connor Kenyon , Glenn Volkema , Gaurav Khanna

Numerical simulations can help solve complex problems. Most of these algorithms are massively parallel and thus good candidates for FPGA acceleration thanks to spatial parallelism. Modern FPGA devices can leverage high-bandwidth memory…

Hardware Architecture · Computer Science 2022-11-09 Stephanie Soldavini , Karl F. A. Friebel , Mattia Tibaldi , Gerald Hempel , Jeronimo Castrillon , Christian Pilato

Emerging applications, such as big data analytics and machine learning, require increasingly large amounts of main memory, often exceeding the capacity of current commodity processors built on DRAM technology. To address this, recent…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-27 Manel Lurbe , Miguel Avargues , Salvador Petit , Maria E. Gomez , Rui Yang , Guanhao Wang , Julio Sahuquillo

Emerging agentic LLM workloads are driving rapidly growing demand on both memory capacity and bandwidth, with different phases of inference (e.g., prefill and decode) imposing distinct requirements. Industry is responding by composing…

State Space Models (SSMs), like recent Mamba2, have achieved remarkable performance and received extensive attention. However, deploying Mamba2 on resource-constrained edge devices encounters many problems: severe outliers within the linear…

Hardware Architecture · Computer Science 2025-07-29 Aotao Wang , Haikuo Shao , Shaobo Ma , Zhongfeng Wang

Large language models (LLMs) have demonstrated remarkable performance across a wide range of language processing tasks. However, this success comes at the cost of substantial computation and memory requirements, which significantly impedes…

Machine Learning · Computer Science 2026-01-21 Fen-Yu Hsieh , Yun-Chang Teng , Ding-Yong Hong , Jan-Jan Wu

Next-generation supercomputers will feature more hierarchical and heterogeneous memory systems with different memory technologies working side-by-side. A critical question is whether at large scale existing HPC applications and emerging…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-04-27 Ivy Bo Peng , Stefano Markidis , Erwin Laure , Gokcen Kestor , Roberto Gioiosa

The rise of generative AI workloads, particularly language model inference, is intensifying on/off-chip memory pressure. Multimodal inputs such as video streams or images and downstream applications like Question Answering (QA) and analysis…

Hardware Architecture · Computer Science 2026-04-14 Joyjit Kundu , Joshua Klein , Aakash Patel , Dwaipayan Biswas

The memory demand of virtual machines (VMs) is increasing, while DRAM has limited capacity and high power consumption. Non-volatile memory (NVM) is an alternative to DRAM, but it has high latency and low bandwidth. We observe that the VM…

Operating Systems · Computer Science 2022-09-28 Sai sha , Chuandong Li , Yingwei Luo , Xiaolin Wang , Zhenlin Wang

GPUs offer orders-of-magnitude higher memory bandwidth than traditional CPU-only systems. However, GPU device memory tends to be relatively small and the memory capacity can not be increased by the user. This paper describes Buddy…

Hardware Architecture · Computer Science 2019-04-17 Esha Choukse , Michael Sullivan , Mike O'Connor , Mattan Erez , Jeff Pool , David Nellans , Steve Keckler

In-memory database query processing frequently involves substantial data transfers between the CPU and memory, leading to inefficiencies due to Von Neumann bottleneck. Processing-in-Memory (PIM) architectures offer a viable solution to…

Mixed-precision quantization is a popular approach for compressing deep neural networks (DNNs). However, it is challenging to scale the performance efficiently with mixed-precision DNNs given the current FPGA architecture and conventional…

Hardware Architecture · Computer Science 2023-11-07 Yuzong Chen , Jordan Dotzel , Mohamed S. Abdelfattah

As high-performance computing (HPC) moves into the exascale era, computer scientists and engineers must find innovative ways of transferring and processing unprecedented amounts of data. As the scale and complexity of the applications…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-09-30 Melissa Romanus , Robert B. Ross , Manish Parashar

Deploying Large Language Models (LLMs) efficiently on edge devices is often constrained by limited memory capacity and high power consumption. Low-bit quantization methods, particularly ternary quantization, have demonstrated significant…

Hardware Architecture · Computer Science 2025-05-02 Chenyang Yin , Zhenyu Bai , Pranav Venkatram , Shivam Aggarwal , Zhaoying Li , Tulika Mitra

Memory bandwidth is known to be a performance bottleneck for FPGA accelerators, especially when they deal with large multi-dimensional data-sets. A large body of work focuses on reducing of off-chip transfers, but few authors try to improve…

Hardware Architecture · Computer Science 2024-01-23 Corentin Ferry , Nicolas Derumigny , Steven Derrien , Sanjay Rajopadhye