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Accurate cell type annotation across datasets is a key challenge in single-cell analysis. snRNA-seq enables profiling of frozen or difficult-to-dissociate tissues, complementing scRNA-seq by capturing fragile or rare cell types. However,…

Genomics · Quantitative Biology 2026-03-10 Xiran Chen , Quan Zou , Qinyu Cai , Xiaofeng Chen , Weikai Li , Yansu Wang

Self-supervised learning (SSL) has proven to be a powerful approach for extracting biologically meaningful representations from single-cell data. To advance our understanding of SSL methods applied to single-cell data, we present…

Quantitative Methods · Quantitative Biology 2025-06-13 Olga Ovcharenko , Florian Barkmann , Philip Toma , Imant Daunhawer , Julia Vogt , Sebastian Schelter , Valentina Boeva

Single-cell RNA sequencing (scRNA-seq) has the potential to provide powerful, high-resolution signatures to inform disease prognosis and precision medicine. This paper takes an important first step towards this goal by developing an…

Quantitative Methods · Quantitative Biology 2021-10-15 Bryan He , Matthew Thomson , Meena Subramaniam , Richard Perez , Chun Jimmie Ye , James Zou

Deep neural networks have been widely used in communication signal recognition and achieved remarkable performance, but this superiority typically depends on using massive examples for supervised learning, whereas training a deep neural…

Signal Processing · Electrical Eng. & Systems 2023-11-15 Weidong Wang , Hongshu Liao , Lu Gan

Deep neural networks are typically trained under a supervised learning framework where a model learns a single task using labeled data. Instead of relying solely on labeled data, practitioners can harness unlabeled or related data to…

Machine Learning · Computer Science 2020-07-03 Huanru Henry Mao

Single-cell RNA-seq (scRNA-seq) enables atlas-scale profiling of complex tissues, revealing rare lineages and transient states. Yet, assigning biologically valid cell identities remains a bottleneck because markers are tissue- and…

We present a novel method for automated identification of putative cell types from single-cell RNA-seq (scRNA-seq) data. By iteratively applying a machine learning approach to an initial clustering of gene expression profiles of a given set…

Quantitative Methods · Quantitative Biology 2020-04-22 Zhichao Miao , Pablo Moreno , Ni Huang , Irene Papatheodorou , Alvis Brazma , Sarah A Teichmann

Use of computational methods to predict gene regulatory networks (GRNs) from gene expression data is a challenging task. Many studies have been conducted using unsupervised methods to fulfill the task; however, such methods usually yield…

Machine Learning · Computer Science 2016-08-15 Nihir Patel , Jason T. L. Wang

Semi-supervised techniques have removed the barriers of large scale labelled set by exploiting unlabelled data to improve the performance of a model. In this paper, we propose a semi-supervised deep multi-task classification and…

Computer Vision and Pattern Recognition · Computer Science 2020-08-12 R. M. Saad Bashir , Talha Qaiser , Shan E Ahmed Raza , Nasir M. Rajpoot

Single-cell RNA sequencing (scRNA-seq) enables the study of cellular diversity at single cell level. It provides a global view of cell-type specification during the onset of biological mechanisms such as developmental processes and human…

Machine Learning · Computer Science 2025-11-05 Muhammad Umar , Andras Lakatos , Muhammad Asif , Arif Mahmood

Inferring gene regulatory networks (GRNs) from single-cell RNA sequencing (scRNA-seq) data is a complex challenge that requires capturing the intricate relationships between genes and their regulatory interactions. In this study, we tackle…

Machine Learning · Computer Science 2024-07-26 Sindhura Kommu , Yizhi Wang , Yue Wang , Xuan Wang

Semantic segmentation with limited annotations, such as weakly supervised semantic segmentation (WSSS) and semi-supervised semantic segmentation (SSSS), is a challenging task that has attracted much attention recently. Most leading WSSS…

Computer Vision and Pattern Recognition · Computer Science 2022-03-22 Junwen Pan , Pengfei Zhu , Kaihua Zhang , Bing Cao , Yu Wang , Dingwen Zhang , Junwei Han , Qinghua Hu

Developments in transcriptomics techniques have caused a large demand in tailored computational methods for modelling gene expression dynamics from experimental data. Recently, so-called single-cell experiments have revolutionised genetic…

Quantitative Methods · Quantitative Biology 2019-03-18 Atte Aalto , Jorge Goncalves

Automatic skin lesion segmentation on dermoscopic images is an essential component in computer-aided diagnosis of melanoma. Recently, many fully supervised deep learning based methods have been proposed for automatic skin lesion…

Computer Vision and Pattern Recognition · Computer Science 2018-08-14 Xiaomeng Li , Lequan Yu , Hao Chen , Chi-Wing Fu , Pheng-Ann Heng

Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of genomic data that populates several online databases and repositories. Here, we…

Genomics · Quantitative Biology 2024-04-17 Mahnoor N. Gondal , Saad Ur Rehman Shah , Arul M. Chinnaiyan , Marcin Cieslik

The success of supervised deep learning models on cell recognition tasks relies on detailed annotations. Many previous works have managed to reduce the dependency on labels. However, considering the large number of cells contained in a…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Pingyi Chen , Chenglu Zhu , Zhongyi Shui , Jiatong Cai , Sunyi Zheng , Shichuan Zhang , Lin Yang

Convolutional neural networks (CNNs) have been successfully applied to solve the problem of correspondence estimation between semantically related images. Due to non-availability of large training datasets, existing methods resort to…

Computer Vision and Pattern Recognition · Computer Science 2019-01-25 Zakaria Laskar , Juho Kannala

Sequencing costs currently prohibit the application of single-cell mRNA-seq to many biological and clinical analyses. Targeted single-cell mRNA-sequencing reduces sequencing costs by profiling reduced gene sets that capture biological…

Genomics · Quantitative Biology 2022-02-15 Xiaoqiao Chen , Sisi Chen , Matt Thomson

Few-shot image classification aims to classify unseen classes with limited labelled samples. Recent works benefit from the meta-learning process with episodic tasks and can fast adapt to class from training to testing. Due to the limited…

Computer Vision and Pattern Recognition · Computer Science 2021-02-24 Da Chen , Yuefeng Chen , Yuhong Li , Feng Mao , Yuan He , Hui Xue

A novel semi-supervised learning technique is introduced based on a simple iterative learning cycle together with learned thresholding techniques and an ensemble decision support system. State-of-the-art model performance and increased…

Computer Vision and Pattern Recognition · Computer Science 2019-06-10 Robert Dupre , Jiri Fajtl , Vasileios Argyriou , Paolo Remagnin