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We propose a novel approach for learning node representations in directed graphs, which maintains separate views or embedding spaces for the two distinct node roles induced by the directionality of the edges. We argue that the previous…

Social and Information Networks · Computer Science 2019-07-01 Megha Khosla , Jurek Leonhardt , Wolfgang Nejdl , Avishek Anand

Feature extraction and dimension reduction for networks is critical in a wide variety of domains. Efficiently and accurately learning features for multiple graphs has important applications in statistical inference on graphs. We propose a…

Applications · Statistics 2021-06-23 Shangsi Wang , Jesús Arroyo , Joshua T. Vogelstein , Carey E. Priebe

Representation learning provides new and powerful graph analytical approaches and tools for the highly valued data science challenge of mining knowledge graphs. Since previous graph analytical methods have mostly focused on homogeneous…

Information Retrieval · Computer Science 2019-05-29 Zheng Gao , Gang Fu , Chunping Ouyang , Satoshi Tsutsui , Xiaozhong Liu , Jeremy Yang , Christopher Gessner , Brian Foote , David Wild , Qi Yu , Ying Ding

The computation of distance measures between nodes in graphs is inefficient and does not scale to large graphs. We explore dense vector representations as an effective way to approximate the same information: we introduce a simple yet…

Computation and Language · Computer Science 2019-06-18 Andrey Kutuzov , Mohammad Dorgham , Oleksiy Oliynyk , Chris Biemann , Alexander Panchenko

Graphs or networks are a very convenient way to represent data with lots of interaction. Recently, Machine Learning on Graph data has gained a lot of traction. In particular, vertex classification and missing edge detection have very…

Machine Learning · Computer Science 2020-09-07 Simon Brandeis , Adrian Jarret , Pierre Sevestre

Molecular activity prediction is critical in drug design. Machine learning techniques such as kernel methods and random forests have been successful for this task. These models require fixed-size feature vectors as input while the molecules…

Machine Learning · Computer Science 2018-01-30 Trang Pham , Truyen Tran , Svetha Venkatesh

Extracting stimulus features from neuronal ensembles is of great interest to the development of neuroprosthetics that project sensory information directly to the brain via electrical stimulation. Machine learning strategies that optimize…

Neurons and Cognition · Quantitative Biology 2020-09-08 Vivek Subramanian , Joshua Khani

Graph neural networks (GNNs) are increasingly used to model biological systems, yet the reliability of post-hoc explanation methods for recovering meaningful molecular mechanisms remains unclear. Here, we systematically evaluate four widely…

Molecular Networks · Quantitative Biology 2026-05-22 Kyle Higgins , Ivan Laponogov , Dennis Veselkov , Kirill Veselkov

At the intersection of computation and cognitive science, graph theory is utilized as a formalized description of complex relationships and structures. Traditional graph models are often static, lacking dynamic and autonomous behavioral…

Neurons and Cognition · Quantitative Biology 2024-06-11 Hui Wei , Chenyue Feng , Jianning Zhang

Masked Graph Auto-Encoder, a powerful graph self-supervised training paradigm, has recently shown superior performance in graph representation learning. Existing works typically rely on node contextual information to recover the masked…

Machine Learning · Computer Science 2025-08-15 Ziyu Zheng , Yaming Yang , Ziyu Guan , Wei Zhao , Weigang Lu

We introduce a new class of auto-encoders for directed graphs, motivated by a direct extension of the Weisfeiler-Leman algorithm to pairs of node labels. The proposed model learns pairs of interpretable latent representations for the nodes…

Machine Learning · Computer Science 2022-02-28 Georgios Kollias , Vasileios Kalantzis , Tsuyoshi Idé , Aurélie Lozano , Naoki Abe

With the rapid development of biomedical software and hardware, a large amount of relational data interlinking genes, proteins, chemical components, drugs, diseases, and symptoms has been collected for modern biomedical research. Many…

Artificial Intelligence · Computer Science 2021-01-21 Yankai Chen , Yaozu Wu , Shicheng Ma , Irwin King

This work presents the use of graph learning for the prediction of multi-step experimental outcomes for applications across experimental research, including material science, chemistry, and biology. The viability of geometric learning for…

Machine Learning · Computer Science 2024-08-13 Amanda A. Volk , Robert W. Epps , Jeffrey G. Ethier , Luke A. Baldwin

Graph neural networks have been used for a variety of learning tasks, such as link prediction, node classification, and node clustering. Among them, link prediction is a relatively under-studied graph learning task, with current…

Machine Learning · Computer Science 2022-08-29 Xinxing Wu , Qiang Cheng

We propose a novel neural network architecture, called autoencoder-constrained graph convolutional network, to solve node classification task on graph domains. As suggested by its name, the core of this model is a convolutional network…

Machine Learning · Computer Science 2021-02-11 Mingyuan Ma , Sen Na , Hongyu Wang

Inspired by the immense success of deep learning, graph neural networks (GNNs) are widely used to learn powerful node representations and have demonstrated promising performance on different graph learning tasks. However, most real-world…

Machine Learning · Computer Science 2020-01-24 Kaize Ding , Yichuan Li , Jundong Li , Chenghao Liu , Huan Liu

Pathway enrichment analysis has become a key tool for biomedical researchers to gain insight into the underlying biology of differentially expressed genes, proteins and metabolites. It reduces complexity and provides a system-level view of…

Methodology · Statistics 2016-06-24 Jing Ma , Ali Shojaie , George Michailidis

Graph neural networks (GNNs) have emerged as a powerful framework for a wide range of node-level graph learning tasks. However, their performance typically depends on random or minimally informed initial feature representations, where poor…

Machine Learning · Computer Science 2026-02-24 Shiyu Chen , Cencheng Shen , Youngser Park , Carey E. Priebe

In anti-cancer drug development, a major scientific challenge is disentangling the complex relationships between high-dimensional genomics data from patient tumor samples, the corresponding tumor's organ of origin, the drug targets…

Machine Learning · Computer Science 2024-03-29 Omid Bazgir , Zichen Wang , Ji Won Park , Marc Hafner , James Lu

Many tasks in graph machine learning, such as link prediction and node classification, are typically solved by using representation learning, in which each node or edge in the network is encoded via an embedding. Though there exists a lot…

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