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We introduce a novel statistical significance-based approach for clustering hierarchical data using semi-parametric linear mixed-effects models designed for responses with laws in the exponential family (e.g., Poisson and Bernoulli). Within…

Methodology · Statistics 2025-02-04 Alessandra Ragni , Chiara Masci , Francesca Ieva , Anna Maria Paganoni

People with learning disabilities have a higher mortality rate and premature deaths compared to the general public, as reported in published research in the UK and other countries. This study analyses hospitalisations of 9,618 patients…

Initial hours of hospital admission impact clinical trajectory, but early clinical decisions often suffer due to data paucity. With clustering analysis for vital signs within six hours of admission, patient phenotypes with distinct…

Due to the wider availability of modern electronic health records, patient care data is often being stored in the form of time-series. Clustering such time-series data is crucial for patient phenotyping, anticipating patients' prognoses by…

Medical Physics · Physics 2020-06-17 Changhee Lee , Mihaela van der Schaar

Accurate and reliable predictions of infectious disease dynamics can be valuable to public health organizations that plan interventions to decrease or prevent disease transmission. A great variety of models have been developed for this…

Machine Learning · Statistics 2018-07-04 Evan L. Ray , Nicholas G. Reich

This paper introduces a novel model-based clustering approach for clustering time series which present changes in regime. It consists of a mixture of polynomial regressions governed by hidden Markov chains. The underlying hidden process for…

Machine Learning · Statistics 2013-12-30 Faicel Chamroukhi , Allou Samé , Patrice Aknin , Gérard Govaert

Ensemble Learning methods combine multiple algorithms performing the same task to build a group with superior quality. These systems are well adapted to the distributed setup, where each peer or machine of the network hosts one algorithm…

Machine Learning · Computer Science 2021-10-19 Gaëlle Candel , David Naccache

This paper sets out a forecasting method that employs a mixture of parametric functions to capture the pattern of fertility with respect to age. The overall level of cohort fertility is decomposed over the range of fertile ages using a…

Applications · Statistics 2019-09-23 Jason Hilton , Erengul Dodd , Jonathan J. Forster , Peter W. F. Smith , Jakub Bijak

The identification of patient subgroups with comparable event-risk dynamics plays a key role in supporting informed decision-making in clinical research. In such settings, it is important to account for the inherent dependence that arises…

Computation · Statistics 2026-01-13 Alessandra Ragni , Lara Cavinato , Francesca Ieva

Clustering analysis is one of the most widely used statistical tools in many emerging areas such as microarray data analysis. For microarray and other high-dimensional data, the presence of many noise variables may mask underlying…

Machine Learning · Statistics 2008-03-26 Benhuai Xie , Wei Pan , Xiaotong Shen

In many fields, researchers are interested in large and complex biological processes. Two important examples are gene expression and DNA methylation in genetics. One key problem is to identify aberrant patterns of these processes and…

Applications · Statistics 2012-10-03 Matthias Kormaksson , James G. Booth , Maria E. Figueroa , Ari Melnick

We propose a new method of classifying documents into categories. The simple method of conducting hypothesis testing over word-based distributions in categories suffers from the data sparseness problem. In order to address this difficulty,…

cmp-lg · Computer Science 2008-02-03 Hang Li , Kenji Yamanishi

Early prediction of the prevalence of influenza reduces its impact. Various studies have been conducted to predict the number of influenza-infected people. However, these studies are not highly accurate especially in the distant future such…

Machine Learning · Computer Science 2019-07-08 Kenjiro Kondo , Akihiko Ishikawa , Masashi Kimura

The widespread adoption of social media has heightened interest in its psychological effects, particularly on mental health indicators such as anxiety, depression, loneliness, and sleep quality, as these platforms increasingly influence…

Machine Learning · Computer Science 2026-04-28 Md All Shahria , Sanjeda Dewan Mithila , Touhid Alam , Mohammad Sakib Mahmood , Mahfuza Khatun

In this paper, we propose a general framework for combining evidence of varying quality to estimate underlying binary latent variables in the presence of restrictions imposed to respect the scientific context. The resulting algorithms…

Methodology · Statistics 2018-08-28 Zhenke Wu , Livia Casciola-Rosen , Antony Rosen , Scott L. Zeger

From neuroscience and genomics to systems biology and ecology, researchers rely on clustering similarity data to uncover modular structure. Yet widely used clustering methods, such as hierarchical clustering, k-means, and WGCNA, lack…

Machine Learning · Statistics 2025-10-20 Magnus Neuman , Jelena Smiljanić , Martin Rosvall

This study presents a semi-nonparametric Latent Class Choice Model (LCCM) with a flexible class membership component. The proposed model formulates the latent classes using mixture models as an alternative approach to the traditional random…

Mixture models and topic models generate each observation from a single cluster, but standard variational posteriors for each observation assign positive probability to all possible clusters. This requires dense storage and runtime costs…

Machine Learning · Statistics 2017-11-15 Michael C. Hughes , Erik B. Sudderth

The preclinical stage of many neurodegenerative diseases can span decades before symptoms become apparent. Understanding the sequence of preclinical biomarker changes provides a critical opportunity for early diagnosis and effective…

Methodology · Statistics 2024-06-11 Yizhen Xu , Scott Zeger , Zheyu Wang

Finite mixture of skew distributions have emerged as an effective tool in modelling heterogeneous data with asymmetric features. With various proposals appearing rapidly in the recent years, which are similar but not identical, the…

Methodology · Statistics 2013-05-29 Sharon X. Lee , Geoffrey J. McLachlan