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The rapid advancement of deep learning has facilitated the automated processing of electron microscopy (EM) big data stacks. However, designing a framework that eliminates manual labeling and adapts to domain gaps remains challenging.…

Materials Science · Physics 2024-07-30 Wenhao Yuan , Bingqing Yao , Shengdong Tan , Fengqi You , Qian He

Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…

Quantitative Methods · Quantitative Biology 2021-05-31 Nanyan Zhu , Chen Liu , Xinyang Feng , Dipika Sikka , Sabrina Gjerswold-Selleck , Scott A. Small , Jia Guo

Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology and background artifacts. In…

Quantitative Methods · Quantitative Biology 2021-03-22 Tamal Batabyal , Aijaz Ahmad Naik , Daniel Weller , Jaideep Kapur

Since the rise of deep learning, many computer vision tasks have seen significant advancements. However, the downside of deep learning is that it is very data-hungry. Especially for segmentation problems, training a deep neural net requires…

Computer Vision and Pattern Recognition · Computer Science 2021-10-13 Robby Neven , Davy Neven , Bert De Brabandere , Marc Proesmans , Toon Goedemé

Due to the rapid innovation of technology and the desire to find and employ biomarkers for neurodegenerative disease, high-dimensional data classification problems are routinely encountered in neuroimaging studies. To avoid over-fitting and…

Machine Learning · Statistics 2018-06-19 Shan Shi , Farouk Nathoo

Applying deep learning to science is a new trend in recent years which leads DL engineering to become an important problem. Although training data preparation, model architecture design, and model training are the normal processes to build…

Machine Learning · Computer Science 2023-01-23 Qiang Hu , Yuejun Guo , Maxime Cordy , Xiaofei Xie , Mike Papadakis , Yves Le Traon

A feature learning task involves training models that are capable of inferring good representations (transformations of the original space) from input data alone. When working with limited or unlabelled data, and also when multiple visual…

Computer Vision and Pattern Recognition · Computer Science 2018-11-02 Gabriel B. Cavallari , Leonardo Sampaio Ferraz Ribeiro , Moacir Antonelli Ponti

Segmenting a structural magnetic resonance imaging (MRI) scan is an important pre-processing step for analytic procedures and subsequent inferences about longitudinal tissue changes. Manual segmentation defines the current gold standard in…

Computer Vision and Pattern Recognition · Computer Science 2017-06-07 Alex Fedorov , Jeremy Johnson , Eswar Damaraju , Alexei Ozerin , Vince Calhoun , Sergey Plis

This work proposed a novel learning objective to train a deep neural network to perform end-to-end image pixel clustering. We applied the approach to instance segmentation, which is at the intersection of image semantic segmentation and…

Computer Vision and Pattern Recognition · Computer Science 2018-03-20 Yen-Chang Hsu , Zheng Xu , Zsolt Kira , Jiawei Huang

Many tasks in computer vision can be cast as a "label changing" problem, where the goal is to make a semantic change to the appearance of an image or some subject in an image in order to alter the class membership. Although successful…

Machine Learning · Computer Science 2016-03-21 Jacob R. Gardner , Paul Upchurch , Matt J. Kusner , Yixuan Li , Kilian Q. Weinberger , Kavita Bala , John E. Hopcroft

The ability to automatically detect certain types of cells or cellular subunits in microscopy images is of significant interest to a wide range of biomedical research and clinical practices. Cell detection methods have evolved from…

Computer Vision and Pattern Recognition · Computer Science 2018-02-22 Yao Xue , Nilanjan Ray

Precise cell classification is essential in biomedical diagnostics and therapeutic monitoring, particularly for identifying diverse cell types involved in various diseases. Traditional cell classification methods such as flow cytometry…

Machine Learning · Computer Science 2025-12-09 Khayrul Islam , Ryan F. Forelli , Jianzhong Han , Deven Bhadane , Jian Huang , Joshua C. Agar , Nhan Tran , Seda Ogrenci , Yaling Liu

Optic disc and cup segmentation plays a crucial role in automating the screening and diagnosis of optic glaucoma. While data-driven convolutional neural networks (CNNs) show promise in this area, the inherent ambiguity of segmenting objects…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 Tengjin Weng , Yang Shen , Zhidong Zhao , Zhiming Cheng , Shuai Wang

Microstructure imaging is crucial in materials science, but experimental images often introduce noise that obscures critical structural details. This study presents a novel deep learning approach for robust microstructure image denoising,…

Materials Science · Physics 2025-07-03 Owais Ahmad , Albert Linda , Saumya Ranjan Jha , Somnath Bhowmick

We present a deep neural network to reduce coherent noise in three-dimensional quantitative phase imaging. Inspired by the cycle generative adversarial network, the denoising network was trained to learn a transform between two image…

The success of modern deep learning algorithms for image segmentation heavily depends on the availability of large datasets with clean pixel-level annotations (masks), where the objects of interest are accurately delineated. Lack of time…

Computer Vision and Pattern Recognition · Computer Science 2021-02-17 Ekaterina Redekop , Alexey Chernyavskiy

Label-free single-cell imaging offers a scalable, non-invasive alternative to fluorescence-based cytometry, yet inferring molecular phenotypes directly from bright-field morphology remains challenging. We present a unified Deep Learning…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Saqib Nazir , Ardhendu Behera

Image segmentation is a fundamental problem in medical image analysis. In recent years, deep neural networks achieve impressive performances on many medical image segmentation tasks by supervised learning on large manually annotated data.…

Computer Vision and Pattern Recognition · Computer Science 2018-01-26 Ling Zhang , Vissagan Gopalakrishnan , Le Lu , Ronald M. Summers , Joel Moss , Jianhua Yao

Medical imaging is a domain which suffers from a paucity of manually annotated data for the training of learning algorithms. Manually delineating pathological regions at a pixel level is a time consuming process, especially in 3D images,…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Christopher Bowles , Roger Gunn , Alexander Hammers , Daniel Rueckert

The acquisition of labels for supervised learning can be expensive. To improve the sample efficiency of neural network regression, we study active learning methods that adaptively select batches of unlabeled data for labeling. We present a…

Machine Learning · Statistics 2023-08-02 David Holzmüller , Viktor Zaverkin , Johannes Kästner , Ingo Steinwart