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Health economic evaluations face the issues of non-compliance and missing data. Here, non-compliance is defined as non-adherence to a specific treatment, and occurs within randomised controlled trials (RCTs) when participants depart from…

Applications · Statistics 2019-02-26 Karla DiazOrdaz , Richard Grieve

This paper develops an inferential theory for high-dimensional matrix-variate factor models with missing observations. We propose an easy-to-use all-purpose method that involves two straightforward steps. First, we perform principal…

Methodology · Statistics 2025-03-26 Yongxia Zhang , Jinwen Liang , Liwen Xu , Keming Yu , Maozai Tian

We identify three issues permeating the literature on statistical methodology for incomplete data written for non-specialist statisticians and other investigators. The first is a mathematical defect in the notation Yobs, Ymis used to…

Other Statistics · Statistics 2019-04-17 John C. Galati

As the availability of omics data has increased in the last few years, more multi-omics data have been generated, that is, high-dimensional molecular data consisting of several types such as genomic, transcriptomic, or proteomic data, all…

Genomics · Quantitative Biology 2023-02-09 Roman Hornung , Frederik Ludwigs , Jonas Hagenberg , Anne-Laure Boulesteix

Chronic disease management and follow-up are vital for realizing sustained patient well-being and optimal health outcomes. Recent advancements in wearable sensing technologies, particularly wrist-worn devices, offer promising solutions for…

The analysis of clinical questionnaire data comes with many inherent challenges. These challenges include the handling of data with missing fields, as well as the overall interpretation of a dataset with many fields of different scales and…

Machine Learning · Computer Science 2021-08-04 Connor J. McLaughlin , Efi G. Kokkotou , Jean A. King , Lisa A. Conboy , Ali Yousefi

Inferring causal effects of treatments is a central goal in many disciplines. The potential outcomes framework is a main statistical approach to causal inference, in which a causal effect is defined as a comparison of the potential outcomes…

Methodology · Statistics 2018-01-04 Peng Ding , Fan Li

This paper proposes an imputation procedure that uses the factors estimated from a tall block along with the re-rotated loadings estimated from a wide block to impute missing values in a panel of data. Assuming that a strong factor…

Econometrics · Economics 2021-08-13 Jushan Bai , Serena Ng

Conditions ensuring optimal parameter estimation in the presence of missing data are well established in inference, typically relying on the Missing-at-Random (MAR) assumption. In prediction, similar principles are often assumed to apply.…

Methodology · Statistics 2026-03-19 Pierre Catoire , Robin Genuer , Cecile Proust-Lima

Time series in real-world applications often have missing observations, making typical analytical methods unsuitable. One method for dealing with missing data is the concept of amplitude modulation. While this principle works with any data,…

Methodology · Statistics 2024-04-19 Simon Nik

This paper presents a general difference-in-differences framework for identifying path-dependent treatment effects when treatment histories are partially observed. We introduce a novel robust estimator that adjusts for missing histories…

Econometrics · Economics 2025-06-18 Akanksha Negi , Didier Nibbering

Missing data is a pervasive challenge spanning diverse data types, including tabular, sensor data, time-series, images and so on. Its origins are multifaceted, resulting in various missing mechanisms. Prior research in this field has…

Machine Learning · Computer Science 2025-03-03 Youran Zhou , Mohamed Reda Bouadjenek , Sunil Aryal

Missing data theory deals with the statistical methods in the occurrence of missing data. Missing data occurs when some values are not stored or observed for variables of interest. However, most of the statistical theory assumes that data…

Multimodal clinical records contain structured measurements and clinical notes recorded over time, offering rich temporal information about the evolution of patient health. Yet these observations are sparse, and whether they are recorded…

Machine Learning · Computer Science 2026-04-24 Zihan Liang , Ziwen Pan , Ruoxuan Xiong

Latent or unobserved phenomena pose a significant difficulty in data analysis as they induce complicated and confounding dependencies among a collection of observed variables. Factor analysis is a prominent multivariate statistical modeling…

Methodology · Statistics 2020-06-22 Armeen Taeb , Venkat Chandrasekaran

Missing data poses a significant challenge in data science, affecting decision-making processes and outcomes. Understanding what missing data is, how it occurs, and why it is crucial to handle it appropriately is paramount when working with…

Methodology · Statistics 2024-04-09 Youran Zhou , Sunil Aryal , Mohamed Reda Bouadjenek

Experimental and observational studies often lack validity due to untestable assumptions. We propose a double machine learning approach to combine experimental and observational studies, allowing practitioners to test for assumption…

A useful technique for analyzing incomplete tables is to model the missing data mechanisms of the variables using log-linear models. In this paper, we use log-linear parametrization and propose estimation methods for arbitrary three-way and…

Methodology · Statistics 2019-10-29 S. Ghosh , P. Vellaisamy

Clinical prediction models must be developed using sufficiently large datasets to minimise overfitting and ensure robust predictive performance. Existing sample size calculations assume complete predictor data for all included participants,…

Longitudinal passive sensing studies for health and behavior outcomes often have missing and incomplete data. Handling missing data effectively is thus a critical data processing and modeling step. Our formative interviews with researchers…