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We present a fully automated learning-based approach for segmenting knee cartilage in the presence of osteoarthritis (OA). The algorithm employs a hierarchical set of two random forest classifiers. The first is a neighborhood approximation…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Satyananda Kashyap , Ipek Oguz , Honghai Zhang , Milan Sonka

The integrity of articular cartilage is a crucial aspect in the early diagnosis of osteoarthritis (OA). Many novel MRI techniques have the potential to assess compositional changes of the cartilage extracellular matrix. Among these…

Computer Vision and Pattern Recognition · Computer Science 2019-12-05 Alejandra Duarte , Chaitra V. Hegde , Aakash Kaku , Sreyas Mohan , José G. Raya

Knee osteoarthritis is a degenerative joint disease that induces chronic pain and disability. Bone morphological analysis is a promising tool to understand the mechanical aspect of this disorder. This study proposes a 2D bone morphological…

Image and Video Processing · Electrical Eng. & Systems 2024-03-14 Yun Xin Teoh , Alice Othmani , Siew Li Goh , Juliana Usman , Khin Wee Lai

Knee Osteoarthritis (KOA) is the third most prevalent Musculoskeletal Disorder (MSD) after neck and back pain. To monitor such a severe MSD, a segmentation map of the femur, tibia and tibiofemoral cartilage is usually accessed using the…

Image and Video Processing · Electrical Eng. & Systems 2024-01-24 Akshay Daydar , Alik Pramanick , Arijit Sur , Subramani Kanagaraj

Analyzing knee cartilage thickness and strain under load can help to further the understanding of the effects of diseases like Osteoarthritis. A precise segmentation of the cartilage is a necessary prerequisite for this analysis. This…

Objective: We evaluate a fully-automated femoral cartilage segmentation model for measuring T2 relaxation values and longitudinal changes using multi-echo spin echo (MESE) MRI. We have open sourced this model and corresponding…

Computer Vision and Pattern Recognition · Computer Science 2020-12-24 Kevin A. Thomas , Dominik Krzemiński , Łukasz Kidziński , Rohan Paul , Elka B. Rubin , Eni Halilaj , Marianne S. Black , Akshay Chaudhari , Garry E. Gold , Scott L. Delp

A fully automated knee MRI segmentation method to study osteoarthritis (OA) was developed using a novel hierarchical set of random forests (RF) classifiers to learn the appearance of cartilage regions and their boundaries. A neighborhood…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Satyananda Kashyap , Honghai Zhang , Karan Rao , Milan Sonka

The 3D morphology and quantitative assessment of knee articular cartilages (i.e., femoral, tibial, and patellar cartilage) in magnetic resonance (MR) imaging is of great importance for knee radiographic osteoarthritis (OA) diagnostic…

Image and Video Processing · Electrical Eng. & Systems 2019-08-14 Chaowei Tan , Zhennan Yan , Shaoting Zhang , Kang Li , Dimitris N. Metaxas

The purpose of this work is to develop a deep learning-based method for knee menisci segmentation in 3D ultrashort echo time (UTE) cones magnetic resonance (MR) imaging, and to automatically determine MR relaxation times, namely the T1,…

Image and Video Processing · Electrical Eng. & Systems 2019-08-06 Michal Byra , Mei Wu , Xiaodong Zhang , Hyungseok Jang , Ya-Jun Ma , Eric Y Chang , Sameer Shah , Jiang Du

Accurate morphometric assessment of cartilage-such as thickness/volume-via MRI is essential for monitoring knee osteoarthritis. Segmenting cartilage remains challenging and dependent on extensive expert-annotated datasets, which are heavily…

Image and Video Processing · Electrical Eng. & Systems 2026-02-24 Danielle L. Ferreira , Bruno A. A. Nunes , Xuzhe Zhang , Laura Carretero Gomez , Maggie Fung , Ravi Soni

In medical image analysis, automated segmentation of multi-component anatomical structures, which often have a spectrum of potential anomalies and pathologies, is a challenging task. In this work, we develop a multi-step approach using…

Image and Video Processing · Electrical Eng. & Systems 2022-12-02 Boyeong Woo , Craig Engstrom , William Baresic , Jurgen Fripp , Stuart Crozier , Shekhar S. Chandra

Osteoarthritis (OA) is one of the major health issues among the elderly population. MRI is the most popular technology to observe and evaluate the progress of OA course. However, the extreme labor cost of MRI analysis makes the process…

Computer Vision and Pattern Recognition · Computer Science 2021-02-17 Boyu Zhang , Yingtao Zhang , H. D. Cheng , Min Xian , Shan Gai , Olivia Cheng , Kuan Huang

Objective: To establish an automated pipeline for post-processing of quantitative spin-lattice relaxation time constant in the rotating frame ($T_{1\rho}$) imaging of knee articular cartilage. Design: The proposed post-processing pipeline…

Image and Video Processing · Electrical Eng. & Systems 2024-09-20 Junru Zhong , Yongcheng Yao , Fan Xiao , Tim-Yun Michael Ong , Ki-Wai Kevin Ho , Siyue Li , Chaoxing Huang , Queenie Chan , James F. Griffith , Weitian Chen

Menisci are cartilaginous tissue found within the knee that contribute to joint lubrication and weight dispersal. Damage to menisci can lead to onset and progression of knee osteoarthritis (OA), a condition that is a leading cause of…

Image and Video Processing · Electrical Eng. & Systems 2025-04-25 Oliver Mills , Philip Conaghan , Nishant Ravikumar , Samuel Relton

This study's objective was to segment spinal metastases in diagnostic MR images using a deep learning-based approach. Segmentation of such lesions can present a pivotal step towards enhanced therapy planning and validation, as well as…

Image and Video Processing · Electrical Eng. & Systems 2020-01-29 Georg Hille , Johannes Steffen , Max Dünnwald , Mathias Becker , Sylvia Saalfeld , Klaus Tönnies

The aim of this study was to investigate the influence of MRI and patient data on the prediction of knee osteoarthritis (OA) incidence using different deep learning architectures. Knee OA incidence within 24 months was predicted using the…

Medical Physics · Physics 2022-09-05 Anastasis Alexopoulos , Jukka Hirvasniemi , Nazli Tümer

Knee osteoarthritis (OA) is the most common musculoskeletal disease in the world. In primary healthcare, knee OA is diagnosed using clinical examination and radiographic assessment. Osteoarthritis Research Society International (OARSI)…

Image and Video Processing · Electrical Eng. & Systems 2019-07-19 Aleksei Tiulpin , Simo Saarakkala

Background: MRI is the modality of choice for cartilage imaging; however, its diagnostic performance is variable and significantly lower than the gold standard diagnostic knee arthroscopy. In recent years, deep learning has been used to…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Gergo Merkely , Alireza Borjali , Molly Zgoda , Evan M. Farina , Simon Gortz , Orhun Muratoglu , Christian Lattermann , Kartik M. Varadarajan

State-of-the-art automated segmentation algorithms are not 100\% accurate especially when segmenting difficult to interpret datasets like those with severe osteoarthritis (OA). We present a novel interactive method called just-enough…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Satyananda Kashyap , Honghai Zhang , Milan Sonka

Purpose: To propose and evaluate an accelerated $T_{1\rho}$ quantification method that combines $T_{1\rho}$-weighted fast spin echo (FSE) images and proton density (PD)-weighted anatomical FSE images, leveraging deep learning models for…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Junru Zhong , Chaoxing Huang , Ziqiang Yu , Fan Xiao , Siyue Li , Tim-Yun Michael Ong , Ki-Wai Kevin Ho , Queenie Chan , James F. Griffith , Weitian Chen
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