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With the increasing availability of patient data, modern medicine is shifting towards prospective healthcare. Electronic health records offer a variety of information useful for clinical patient characterization and the development of…

Machine Learning · Computer Science 2025-05-27 Fabio Azzalini , Tommaso Dolci , Marco Vagaggini

Unsupervised learning is often used to uncover clusters in data. However, different kinds of noise may impede the discovery of useful patterns from real-world time-series data. In this work, we focus on mitigating the interference of…

Machine Learning · Statistics 2021-12-07 Irene Y. Chen , Rahul G. Krishnan , David Sontag

Many diseases, including cancer and chronic conditions, require extended treatment periods and long-term strategies. Machine learning and AI research focusing on electronic health records (EHRs) have emerged to address this need. Effective…

We present a comprehensive analysis of deep learning approaches for Electronic Health Record (EHR) time-series imputation, examining how architectural and framework biases combine to influence model performance. Our investigation reveals…

Machine Learning · Computer Science 2025-02-05 Linglong Qian , Tao Wang , Jun Wang , Hugh Logan Ellis , Robin Mitra , Richard Dobson , Zina Ibrahim

Sepsis is a life-threatening host response to infection associated with high mortality, morbidity, and health costs. Its management is highly time-sensitive since each hour of delayed treatment increases mortality due to irreversible organ…

Machine Learning · Computer Science 2020-10-16 Michael Moor , Max Horn , Bastian Rieck , Damian Roqueiro , Karsten Borgwardt

We introduce a novel profile-based patient clustering model designed for clinical data in healthcare. By utilizing a method grounded on constrained low-rank approximation, our model takes advantage of patients' clinical data and digital…

Machine Learning · Computer Science 2023-08-24 Dongjin Choi , Andy Xiang , Ozgur Ozturk , Deep Shrestha , Barry Drake , Hamid Haidarian , Faizan Javed , Haesun Park

Trace clustering has increasingly been applied to find homogenous process executions. However, current techniques have difficulties in finding a meaningful and insightful clustering of patients on the basis of healthcare data. The resulting…

Databases · Computer Science 2020-01-13 Xixi Lu , Seyed Amin Tabatabaei , Mark Hoogendoorn , Hajo A. Reijers

We present a pipeline in which unsupervised machine learning techniques are used to automatically identify subtypes of hospital patients admitted between 2017 and 2021 in a large UK teaching hospital. With the use of state-of-the-art…

Disease progression modeling (DPM) involves using mathematical frameworks to quantitatively measure the severity of how certain disease progresses. DPM is useful in many ways such as predicting health state, categorizing disease stages, and…

Machine Learning · Computer Science 2021-10-12 Zicong Zhang , Changchang Yin , Ping Zhang

Optimization of patient throughput and wait time in emergency departments (ED) is an important task for hospital systems. For that reason, Emergency Severity Index (ESI) system for patient triage was introduced to help guide manual…

Computers and Society · Computer Science 2018-04-11 Djordje Gligorijevic , Jelena Stojanovic , Wayne Satz , Ivan Stojkovic , Kathrin Schreyer , Daniel Del Portal , Zoran Obradovic

Machine learning has been widely used in healthcare applications to approximate complex models, for clinical diagnosis, prognosis, and treatment. As deep learning has the outstanding ability to extract information from time series, its true…

Machine Learning · Computer Science 2022-11-14 Ke Liao , Wei Wang , Armagan Elibol , Lingzhong Meng , Xu Zhao , Nak Young Chong

Readmissions among Medicare beneficiaries are a major problem for the US healthcare system from a perspective of both healthcare operations and patient caregiving outcomes. Our study analyzes Medicare hospital readmissions using LSTM…

Machine Learning · Computer Science 2024-10-24 Xintao Li , Sibei Liu , Dezhi Yu , Yang Zhang , Xiaoyu Liu

Clinical time series data are critical for patient monitoring and predictive modeling. These time series are typically multivariate and often comprise hundreds of heterogeneous features from different data sources. The grouping of features…

Machine Learning · Computer Science 2025-11-12 Fedor Sergeev , Manuel Burger , Polina Leshetkina , Vincent Fortuin , Gunnar Rätsch , Rita Kuznetsova

Machine learning (ML) applied to routine patient monitoring within intensive care units (ICUs) has the potential to improve care by providing clinicians with novel insights into each patient's health and expected response to interventions.…

Signal Processing · Electrical Eng. & Systems 2024-06-26 Thomas Kite , Uzair Tahamid Siam , Brian Ayers , Nicholas Houstis , Aaron D Aguirre

Intensive Care Unit Electronic Health Records (ICU EHRs) store multimodal data about patients including clinical notes, sparse and irregularly sampled physiological time series, lab results, and more. To date, most methods designed to learn…

Machine Learning · Computer Science 2021-03-22 Satya Narayan Shukla , Benjamin M. Marlin

We aim to comprehensively identify typical life-spanning trajectories and critical events that impact patients' hospital utilization and mortality. We use a unique dataset containing 44 million records of almost all inpatient stays from…

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman

Integrating multimodal Electronic Health Records (EHR) data, such as numerical time series and free-text clinical reports, has great potential in predicting clinical outcomes. However, prior work has primarily focused on capturing temporal…

Machine Learning · Computer Science 2025-11-10 Fuying Wang , Feng Wu , Yihan Tang , Lequan Yu

Problem definition: Access to accurate predictions of patients' outcomes can enhance medical staff's decision-making, which ultimately benefits all stakeholders in the hospitals. A large hospital network in the US has been collaborating…

Determining phenotypes of diseases can have considerable benefits for in-hospital patient care and to drug development. The structure of high dimensional data sets such as electronic health records are often represented through an embedding…