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Large-scale force generation is essential for biological functions such as cell motility, embryonic development, and muscle contraction. In these processes, forces generated at the molecular level by motor proteins are transmitted by…

Soft Condensed Matter · Physics 2016-04-05 Pierre Ronceray , Chase Broedersz , Martin Lenz

Athermal models of disordered fibrous networks are highly useful for studying the mechanics of elastic networks composed of stiff biopolymers. The underlying network architecture is a key aspect that can affect the elastic properties of…

Soft Condensed Matter · Physics 2016-01-20 Albert James Licup , Abhinav Sharma , Fred C. MacKintosh

Networks of elastic beams can deform either by stretching or bending of their members. The primary mode of deformation (bending or stretching) crucially depends on the specific details of the network architecture. In order to shed light on…

Soft Condensed Matter · Physics 2016-09-23 Gérald Gurtner , Marc Durand

Collagen is the most abundant extracellular-network-forming protein in animal biology and is important in both natural and artificial tissues, where it serves as a material of great mechanical versatility. This versatility arises from its…

Soft Condensed Matter · Physics 2009-07-13 D. Vader , A. Kabla , D. Weitz , L. Mahadevan

Cells actively probe and respond to the stiffness of their surroundings. Since mechanosensory cells in connective tissue are surrounded by a disordered network of biopolymers, their in vivo mechanical environment can be extremely…

Soft Condensed Matter · Physics 2016-08-05 Farzan Beroz , Louise M. Jawerth , Stefan Münster , David A. Weitz , Chase P. Broedersz , Ned S. Wingreen

Disordered elastic networks provide a framework for describing a wide variety of physical systems, ranging from amorphous solids, through polymeric fibrous materials to confluent cell tissues. In many cases, such networks feature two widely…

Soft Condensed Matter · Physics 2024-09-02 Edan Lerner , Eran Bouchbinder

The mechanical response of biological soft tissues is influenced by wall heterogeneity, including spatial variations in wall thickness. Traditional models for homogeneous soft tissues under uniaxial loading predict higher stretch and stress…

Tissues and Organs · Quantitative Biology 2026-02-06 Yamnesh Agrawal , Masoud Zamani , James R. Thunes , Spandan Maiti , Anne M. Robertson

The robustness of dynamical properties of neuronal networks against structural damages is a central problem in computational and experimental neuroscience. Research has shown that the cortical network of a healthy brain works near a…

Neurons and Cognition · Quantitative Biology 2018-08-17 Abdorreza Goodarzinick , Mohammad D. Niry , Alireza Valizadeh , Matjaz Perc

Fibrous networks are ideal functional materials since they provide mechanical rigidity at low weight. Such structures are omnipresent in natural biomaterials from cells to tissues, as well as in man-made materials from polymeric composites…

Collagen forms the structural scaffold of connective tissues in all mammals. Tissues are remarkably resistant against mechanical deformations because collagen molecules hierarchically self-assemble in fibrous networks that stiffen with…

Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber…

Analysis of PDEs · Mathematics 2008-12-04 Christian Bourdarias , Stéphane Gerbi , Jacques Ohayon

We present theoretical and experimental studies of the elastic response of fibrous networks subjected to uniaxial strain. Uniaxial compression or extension is applied to extracellular networks of fibrin and collagen using a shear rheometer…

Here, we provide an overview of theoretical approaches to semiflexible polymers and their networks. Such semiflexible polymers have large bending rigidities that can compete with the entropic tendency of a chain to crumple up into a random…

Soft Condensed Matter · Physics 2016-05-25 Chase P. Broedersz , Fred. C. MacKintosh

The collective action of actively contractile units embedded in elastic biopolymer networks plays a crucial role in regulating the network's macroscopic mechanical response. Here, we investigate how the macroscopic boundary stress in model…

Soft Condensed Matter · Physics 2026-03-25 Abhinav Kumar , David A. Quint , Kinjal Dasbiswas

We study the elasticity of random stiff fiber networks. The elastic response of the fibers is characterized by a central force stretching stiffness as well as a bending stiffness that acts transverse to the fiber contour. Previous studies…

Soft Condensed Matter · Physics 2007-10-02 Claus Heussinger , Erwin Frey

We present a theory for the elasticity of cross-linked stiff polymer networks. Stiff polymers, unlike their flexible counterparts, are highly anisotropic elastic objects. Similar to mechanical beams stiff polymers easily deform in bending,…

Soft Condensed Matter · Physics 2007-11-26 C. Heussinger , B. Schaefer , E. Frey

Collagen is the main structural and load-bearing element of various connective tissues, where it forms the extracellular matrix that supports cells. It has long been known that collagenous tissues exhibit a highly nonlinear stress-strain…

Recently, the concept of geometric renormalization group provides a good approach for studying the structural symmetry and functional invariance of complex networks. Along this line, we systematically investigate the finite-size scaling of…

Physics and Society · Physics 2021-09-15 Dan Chen , Housheng Su , Xiaofan Wang , Gui-Jun Pan , Guanrong Chen

In this work we analyze how effects of finite size may modify the thermodynamics of a system of strongly interacting fermions that we model using an effective field theory with four-point interactions at finite temperature and density and…

High Energy Physics - Theory · Physics 2015-06-11 Antonino Flachi

Many biological materials consist of sparse networks of disordered fibres, embedded in a soft elastic matrix. The interplay between rigid and soft elements in such composite networks leads to mechanical properties that can go far beyond the…

Soft Condensed Matter · Physics 2017-04-26 Jan Maarten van Doorn , Luuk Lageschaar , Joris Sprakel , Jasper van der Gucht