Related papers: Nonlocal adhesion models for two cancer cell pheno…
A mathematical analysis of local and nonlocal phase-field models of tumor growth is presented that includes time-dependent Darcy-Forchheimer-Brinkman models of convective velocity fields and models of long-range cell interactions. A…
The conventional cancer stem cell (CSC) theory indicates a hierarchy of CSCs and non-stem cancer cells (NSCCs), that is, CSCs can differentiate into NSCCs but not vice versa. However, an alternative paradigm of CSC theory with reversible…
Cell membranes interact via anchored receptor and ligand molecules. Central questions on cell adhesion concern the binding affinity of these membrane-anchored molecules, the mechanisms leading to the receptor-ligand domains observed during…
We study the Abels-Garcke-Gr\"un (AGG) model for a mixture of two viscous incompressible fluids with different densities. The AGG model consists of a Navier-Stokes-Cahn-Hilliard system characterized by a (non-constant)…
Cell migration plays a fundamental role in numerous physiological processes, including embryonic development, wound healing, and cancer metastasis. While cell-cell adhesion is known to regulate motion by shaping cell morphology and…
We consider a class of nonlocal viscous Cahn-Hilliard equations with Neumann boundary conditions for the chemical potential. The double-well potential is allowed to be singular (e.g. of logarithmic type), while the singularity of the…
Nonlinear stiffening is a ubiquitous property of major types of biopolymers that make up the extracellular matrices (ECM) including collagen, fibrin and basement membrane. Within the ECM, many types of cells such as fibroblasts and cancer…
We discovered a class of self-similar solutions in nonlinear models describing the formation of morphogen gradients, the concentration fields of molecules acting as spatial regulators of cell differention in developing tissues. These models…
We report here new electrical laws, derived from nonlinear electro-diffusion theory, about the effect of the local geometrical structure, such as curvature, on the electrical properties of a cell. We adopt the Poisson-Nernst-Planck (PNP)…
Quantum systems are often classified into Hermitian and non-Hermitian ones. Extraordinary non-Hermitian phenomena, ranging from the non-Hermitian skin effect to the supersensitivity to boundary conditions, have been widely explored. Whereas…
We discuss the relation between entanglement and nonlocality in the hidden nonlocality scenario. Hidden nonlocality signifies nonlocality that can be activated by applying local filters to a particular state that admits a local…
In this manuscript, we study a nonlinear model of tumor growth, described by a coupled hyperbolic-elliptic system of partial differential equations. In this model, the compressible flow of tumor cells is modeled by a transport equation for…
We study a class of nonlocal, energy-driven dynamical models that govern the motion of closed, embedded curves from both an energetic and dynamical perspective. Our energetic results provide a variety of ways to understand physically…
We present and analyse a model for cell signalling processes in biological tissues. The model includes diffusion and nonlinear reactions on the cell surfaces, and both inter- and intracellular signalling. Using techniques from the theory of…
Experimental studies of cell motility in culture have shown that under adequate conditions these living organisms possess the ability to organize themselves into complex structures. Such structures may exhibit a synergy that greatly…
A two-dimensional free boundary model for the growth of multi-layer tumors has been proposed in [S. Cui, J. Escher: ARMA 191 (2009) 173-193] where the authors derive well-posedness in a functional analytic setting, the stationary solutions…
We present initial results regarding the existence, stability and interaction of linear and nonlinear vibrational modes in a system of two coupled, one dimensional lattices with unequal numbers of masses. The effects on these nonlinear…
Recent biological experiments have shown that certain types of cells are able to move in structured and confined environment even without the activation of focal adhesion. Focusing on this particular phenomenon and based on previous works,…
A fully parabolic chemotaxis model of Keller-Segel type with local sensing is considered. The system features a signal-dependent asymptotically non-degenerate motility function, which accounts for a repulsion-dominated chemotaxis. Global…
Phase-field models of tumour growth have proved useful as theoretical tools to investigate cancer invasion. A key implicit assumption underlying mathematical models of this type which have so far been proposed, though, is that cells in the…