Related papers: Signaling activations through G-protein-coupled-re…
Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the…
The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce…
This paper focuses on molecular communication (MC) systems using two types of signaling molecules which may participate in a reversible bimolecular reaction in the channel. The motivation for studying these MC systems is that they can…
The receptive fields of simple cells in the visual cortex can be understood as linear filters. These filters can be modelled by Gabor functions, or by Gaussian derivatives. Gabor functions can also be combined in an `energy model' of the…
A number of scenarios for the formation of multiple populations in globular clusters (GCs) predict that second generation (2G) stars form in a compact and dense subsystem embedded in a more extended first-generation (1G) system. If these…
The dispersal of cells from an initially constrained location is a crucial aspect of many physiological phenomena ranging from morphogenesis to tumour spreading. In such processes, the way cell-cell interactions impact the motion of single…
Motility induced phase separation is an efficient aggregation mechanism of active matter, yet biological systems exhibit richer organization through communication among constituents. We investigate suspensions of active particles that…
The prospect of new biological and industrial applications that require communication in micro-scale, encourages research on the design of bio-compatible communication networks using networking primitives already available in nature. One of…
Graph neural networks (GNNs) have achieved great success in many graph learning tasks. The main aspect powering existing GNNs is the multi-layer network architecture to learn the nonlinear graph representations for the specific learning…
Studies of how protein fold have shown that the way protein clumps form in the test tube is similar to how proteins form the so-called ``amyloid'' deposits that are the pathological signal of a variety of diseases, among them the memory…
Our interest lies in exploring the ability of a coupled nonlocal system of two quasilinear parabolic partial differential equations to produce phase separation patterns. The obtained patterns are referred here as morphologies. Our target…
Advances in neural recording methods enable sampling from populations of thousands of neurons during the performance of behavioral tasks, raising the question of how recorded activity relates to the theoretical models of computations…
In this paper we show that living cells can multiplex biochemical signals, i.e. transmit multiple signals through the same signaling pathway simultaneously, and yet respond to them very specifically. We demonstrate how two binary input…
The advanced gravitational wave (GW) detector network has started {routine detection of } signals from merging compact binaries. Data indicate that in a fair fraction of these sources, at least one component was a neutron star, bringing…
We generalize the Cable Model to describe the transport characteristics of the gap junctions coupling adjacent cells in the heart muscle. Our model takes into account recent experimental information about the time dependence of the…
T-cell receptors (TCRs) play a crucial role in the immune system by recognizing and binding to specific antigens presented by infected or cancerous cells. Understanding the sequence patterns of TCRs is essential for developing targeted…
General relativity (GR) has been extensively tested in the solar system and in binary pulsars, but never in the strong-field, dynamical regime. Soon, gravitational-wave (GW) detectors like Advanced LIGO and eLISA will be able to probe this…
Gene expression dynamics satisfying given input-output relationships were investigated by evolving the networks for an optimal response. We found three types of networks and corresponding dynamics, depending on the sensitivity of gene…
Radiation-reaction forces originating from the emission of gravitational waves (GW) bring binaries to close proximity and are thus responsible for virtually all the mergers that we can observe in GW interferometers. We show that there…
Whether a sub-optimum lymphocyte stimulus is achieved by lowering ligand concentration, or decreasing its affinity, initial TCR activation responses are likely to be digital. We now know for cultured peripheral blood mononuclear cells…