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The Poisson-Boltzmann equation (PBE) is a fundamental implicit solvent continuum model for calculating the electrostatic potential of large ionic solvated biomolecules. However, its numerical solution encounters severe challenges arising…

Numerical Analysis · Mathematics 2021-03-02 Cleophas Kweyu , Lihong Feng , Matthias Stein , Peter Benner

We study the geometric ergodicity and the long time behavior of the Random Batch Method for interacting particle systems, which exhibits superior numerical performance in recent large-scale scientific computing experiments. We show that for…

Probability · Mathematics 2022-05-16 Shi Jin , Lei Li , Xuda Ye , Zhennan Zhou

We present the open source distributed software package Poisson-Boltzmann Analytical Method (PB-AM), a fully analytical solution to the linearized Poisson Boltzmann equation, for molecules represented as non-overlapping spherical cavities.…

Biomolecules · Quantitative Biology 2016-09-27 Lisa E. Feldberg , David H. Brookes , Eng-Hui Yap , Elizabeth Jurrus , Nathan Baker , Teresa Head-Gordon

In this paper we study binary interaction schemes with uncertain parameters for a general class of Boltzmann-type equations with applications in classical gas and aggregation dynamics. We consider deterministic (i.e., a priori averaged) and…

Analysis of PDEs · Mathematics 2018-11-05 Andrea Tosin , Mattia Zanella

We have developed efficient numerical algorithms for solving 3D steady-state Poisson-Nernst-Planck (PNP) equations with excess chemical potentials described by the classical density functional theory (cDFT). The coupled PNP equations are…

Numerical Analysis · Mathematics 2016-08-24 Da Meng , Bin Zheng , Guang Lin , Maria L. Sushko

The non-linear Poisson-Boltzmann equation for a circular, uniformly charged platelet, confined together with co- and counter-ions to a cylindrical cell, is solved semi-analytically by transforming it into an integral equation and solving…

Soft Condensed Matter · Physics 2009-10-31 R. J. F. Leote de Carvalho , E. Trizac , J. P Hansen

An efficient sampling method, the pmmLang+RBM, is proposed to compute the quantum thermal average in the interacting quantum particle system. Benefiting from the random batch method (RBM), the pmmLang+RBM reduces the complexity due to the…

Quantum Physics · Physics 2021-06-16 Xuda Ye , Zhennan Zhou

With the significant advancements in parallel computing techniques, the particle-particle (PP) model has been effectively utilized in various plasma-related applications. However, PP has been limited for solving only electrostatic problems…

Plasma Physics · Physics 2025-05-26 Yanan Zhang , Xiaochun Ma , Hui Liu , Yinjian Zhao

In this paper, we introduce and analyze a class of numerical schemes that demonstrate remarkable superiority in terms of efficiency, the preservation of positivity, energy stability, and high-order precision to solve the time-dependent…

Numerical Analysis · Mathematics 2025-07-01 Waixiang Cao , Yuzhe Qin , Minqiang Xu

As a counterpoint to classical stochastic particle methods for diffusion, we develop a deterministic particle method for linear and nonlinear diffusion. At first glance, deterministic particle methods are incompatible with diffusive partial…

Analysis of PDEs · Mathematics 2019-03-05 José Antonio Carrillo , Katy Craig , Francesco S. Patacchini

This work introduces novel unconditionally stable operator splitting methods for solving the time dependent nonlinear Poisson-Boltzmann (NPB) equation for the electrostatic analysis of solvated biomolecules. In a pseudo-transient…

Numerical Analysis · Mathematics 2014-10-13 Leighton Wilson , Shan Zhao

The non-equilibrium steady states of a semi-infinite quasi-one-dimensional univalent binary electrolyte solution, characterised by non-vanishing electric currents, are investigated by means of Poisson-Nernst-Planck (PNP) theory. Exact…

Soft Condensed Matter · Physics 2024-01-09 Markus Bier

The Poisson Nernst-Planck equations for charge concentration and electric potential in a ball is a model of electro-diffusion of ions in the head of a neuronal dendritic spine. We study the relaxation and the steady state when an initial…

Classical Physics · Physics 2015-05-12 Z. Schuss J. Cartailler , D. Holcman

In the framework of a multiscale modeling approach, we present a systematic study of a bipolar rectifying nanopore using a continuum and a particle simulation method. The common ground in the two methods is the application of the…

The Poisson-Nernst-Planck (PNP) system is a widely accepted model for simulation of ionic channels. In this paper, we design, analyze, and numerically validate a second order unconditional positivity-preserving scheme for solving a reduced…

Numerical Analysis · Mathematics 2019-10-01 Hailiang Liu , Wumaier Maimaitiyiming

With the great development of parallel computing techniques, the particle-particle (PP) model has been successfully applied in a number of plasma applications. Comparing to particle-mesh (PM) models, for example the widely used…

Plasma Physics · Physics 2025-06-10 Yanan Zhang , Xiaochun Ma , Hui Liu , Yinjian Zhao

A number of problems arise when long-range forces, such as those governed by Bessel functions, are used in particle-particle simulations. If a simple cut-off for the interaction is used, the system may find an equilibrium configuration at…

Computational Physics · Physics 2009-11-06 Hans Fangohr , Andrew R. Price , Simon J. Cox , Peter A. J. de Groot , Geoffrey J. Daniell , Ken S. Thomas

In this article, a formulation of a point-collocation method in which the unknown function is approximated using global expansion in tensor product Bernstein polynomial basis is presented. Bernstein polynomials used in this study are…

Numerical Analysis · Mathematics 2012-11-16 Nikola Mirkov , Bosko Rasuo

In this paper, we present a parallel higher-order boundary integral method to solve the linear Poisson-Boltzmann (PB) equation. In our method, a well-posed boundary integral formulation is used to ensure the fast convergence of Krylov…

Numerical Analysis · Mathematics 2015-06-12 Weihua Geng

Hybrid particle-field methods are computationally efficient approaches for modelling soft matter systems. So far applications of these methodologies have been limited to constant volume conditions. Here, we reformulate particle-field…