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In a recent work we introduced a novel method to compute the effective reproduction number $R_t$ and we applied it to describe the development of the COVID-19 outbreak in Italy. The study is based on the number of daily positive swabs as…

Testing of symptomatic persons for infection with SARS-CoV-2 is occurring worldwide. We propose two types of case-control studies that can be carried out jointly in test-settings for symptomatic persons. The first, the test-negative…

Populations and Evolution · Quantitative Biology 2021-06-08 Jan P Vandenbroucke , Elizabeth B Brickley , Christina M J E Vandenbroucke-Grauls , Neil Pearce

Motivated by the increasing number of COVID-19 cases that have been observed in many countries after the vaccination and relaxation of non-pharmaceutical interventions, we propose a mathematical model on time-varying networks for the spread…

Dynamical Systems · Mathematics 2022-03-09 Kathinka Frieswijk , Lorenzo Zino , Ming Cao

The epidemiology of pandemics is classically viewed using geographical and political borders; however, these artificial divisions can result in a misunderstanding of the current epidemiological state within a given region. To improve upon…

Populations and Evolution · Quantitative Biology 2023-11-28 David Lyver , Mihai Nica , Corentin Cot , Giacomo Cacciapaglia , Zahra Mohammadi , Edward W. Thommes , Monica-Gabriela Cojocaru

Long-term care facilities have been widely affected by the COVID-19 pandemic. Retirement homes are particularly vulnerable due to the higher mortality risk of infected elderly individuals. Once an outbreak occurs, suppressing the spread of…

Optimization and Control · Mathematics 2022-04-06 Mansoor Davoodi , Ana Batista , Abhishek Senapati , Weronika Schlechte-Welnicz , Birgit Wagner , Justin M. Calabrese

The COVID-19 pandemic began over two years ago, yet schools, businesses, and other organizations are still struggling to keep the risk of disease outbreak low while returning to (near) normal functionality. Observations from these past…

Populations and Evolution · Quantitative Biology 2022-02-02 Sarah C. Fay , Dalton J. Jones , Munther A. Dahleh , A. E. Hosoi

Social distancing has been the only effective way to contain the spread of an infectious disease prior to the availability of the pharmaceutical treatment. It can lower the infection rate of the disease at the economic cost. A pandemic…

Applications · Statistics 2020-12-07 Kexin Chen , Chi Seng Pun , Hoi Ying Wong

The corona virus disease 2019 (COVID-19) caused by the novel corona virus has an exponential rate of infection. COVID-19 is particularly notorious as the onset of symptoms in infected patients are usually delayed and there exists a large…

Methodology · Statistics 2020-04-16 Lakshmi N. Theagarajan

Two stochastic models are proposed to describe the evolution of the COVID-19 pandemic. In the first model the population is partitioned into four compartments: susceptible $S$, infected $I$, removed $R$ and dead people $D$. In order to have…

Populations and Evolution · Quantitative Biology 2021-09-16 Fabiana Calleri , Giovanni Nastasi , Vittorio Romano

Having accurate and timely data on confirmed active COVID-19 cases is challenging, since it depends on testing capacity and the availability of an appropriate infrastructure to perform tests and aggregate their results. In this paper, we…

The pandemic linked to COVID-19 infection represents an unprecedented clinical and healthcare challenge for many medical researchers attempting to prevent its worldwide spread. This pandemic also represents a major challenge for…

Measuring the prevalence of active SARS-CoV-2 infections in the general population is difficult because tests are conducted on a small and non-random segment of the population. However, people admitted to the hospital for non-COVID reasons…

Econometrics · Economics 2021-03-23 Daniel W. Sacks , Nir Menachemi , Peter Embi , Coady Wing

Since the beginning of the epidemic, daily reports of CoViD-19 cases, hospitalizations, and deaths from around the world have been publicly available. This paper describes methods to characterize broad features of the spread of the disease,…

Physics and Society · Physics 2020-07-15 Dean Karlen

We investigate adaptive strategies to robustly and optimally control the COVID-19 pandemic via social distancing measures based on the example of Germany. Our goal is to minimize the number of fatalities over the course of two years without…

Populations and Evolution · Quantitative Biology 2021-02-09 Johannes Köhler , Lukas Schwenkel , Anne Koch , Julian Berberich , Patricia Pauli , Frank Allgöwer

At the time of this article, COVID-19 has been transmitted to more than 42 million people and resulted in more than 673,000 deaths across the United States. Throughout this pandemic, public health authorities have monitored the results of…

Computers and Society · Computer Science 2021-10-19 Zhen Zhong , Ribhu Sengupta , Kamran Paynabar , Lance A. Waller

The detection and management of diseases become quite complicated when pathogens contain asymptomatic phenotypes amongst their ranks, as evident during the recent COVID-19 pandemic. Spreading of diseases has been studied extensively under…

Physics and Society · Physics 2021-10-27 Saptarshi Sinha , Deep Nath , Soumen Roy

Strong social distancing restrictions have been crucial to controlling the COVID-19 outbreak thus far, and the next question is when and how to relax these restrictions. A sequential timing of relaxing restrictions across groups is explored…

Populations and Evolution · Quantitative Biology 2020-05-14 Henry Zhao , Zhilan Feng , Carlos Castillo-Chavez , Simon A. Levin

Coronavirus case-count data has influenced government policies and drives most epidemiological forecasts. Limited testing is cited as the key driver behind minimal information on the COVID-19 pandemic. While expanded testing is laudable,…

Methodology · Statistics 2022-09-22 Walter Dempsey

In this work, we provide a general mathematical formalism to study the optimal control of an epidemic, such as the COVID-19 pandemic, via incentives to lockdown and testing. In particular, we model the interplay between the government and…

Populations and Evolution · Quantitative Biology 2022-04-14 Emma Hubert , Thibaut Mastrolia , Dylan Possamaï , Xavier Warin

I use a very simple deterministic model for the spread of Covid-19 in a large population. Using this to compare the relative decay of the number of deaths per day between different regions in Italy, Spain and England, each applying in…

Populations and Evolution · Quantitative Biology 2020-05-26 Robert S Thorne