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Large-scale testing is crucial in pandemic containment, but resources are often prohibitively constrained. We study the optimal application of pooled testing for populations that are heterogeneous with respect to an individual's infection…

Computer Science and Game Theory · Computer Science 2023-09-22 Simon Finster , Michelle González Amador , Edwin Lock , Francisco Marmolejo-Cossío , Evi Micha , Ariel D. Procaccia

Monitoring key elements of disease dynamics (e.g., prevalence, case counts) is of great importance in infectious disease prevention and control, as emphasized during the COVID-19 pandemic. To facilitate this effort, we propose a new…

Methodology · Statistics 2024-10-10 Lin Ge , Yuzi Zhang , Lance A. Waller , Robert H. Lyles

Many biomedical experiments are carried out by pooling individual biological samples. However, pooling samples can potentially hide biological variance and give false confidence concerning the data significance. In the context of microarray…

Quantitative Methods · Quantitative Biology 2008-06-02 Shu-Dong Zhang , Timothy W. Gant

One of the main problems in controlling COVID-19 epidemic spread is the delay in confirming cases. Having information on changes in the epidemic evolution or outbreaks rise before lab-confirmation is crucial in decision making for Public…

Populations and Evolution · Quantitative Biology 2020-10-14 Ezequiel Alvarez , Daniela Obando , Sebastian Crespo , Enio Garcia , Nicolas Kreplak , Franco Marsico

We introduce a new method for inference in stochastic epidemic models which uses recursive multinomial approximations to integrate over unobserved variables and thus circumvent likelihood intractability. The method is applicable to a class…

Methodology · Statistics 2021-02-24 Nick Whiteley , Lorenzo Rimella

Statistical inference for large data panels is omnipresent in modern economic applications. An important benefit of panel analysis is the possibility to reduce noise and thus to guarantee stable inference by intersectional pooling. However,…

Methodology · Statistics 2022-12-15 Tim Kutta , Holger Dette

The log-normal distribution is used to describe the positive data, that it has skewed distribution with small mean and large variance. This distribution has application in many sciences for example medicine, economics, biology and…

Methodology · Statistics 2015-08-10 Saba Aghadoust , Kamel Abdollahnezhad , Farhad Yaghmaei , Ali Akbar Jafari

In India the COVID-19 infected population has not yet been accurately established. As always in the early stages of any epidemic, the need to test serious cases first has meant that the population with asymptomatic or mild sub-clinical…

Populations and Evolution · Quantitative Biology 2020-04-09 Sourendu Gupta , R. Shankar

We consider the problem of deciding on sampling strategy, in particular sampling design. We propose a risk measure, whose minimizing value guides the choice. The method makes use of a superpopulation model and takes into account uncertainty…

Methodology · Statistics 2020-07-06 Edgar Bueno , Dan Hedlin

The COVID-19 pandemic has plagued the world for months. The U.S. has taken measures to counter it. On a daily basis, newly confirmed cases have been reported. In the early days, these numbers showed an increasing trend. Recently, the…

Physics and Society · Physics 2020-05-21 Xiubin Bruce Wang , Chaolun Ma

The usual development cycles are too slow for the development of vaccines, diagnostics and treatments in pandemics such as the ongoing SARS-CoV-2 pandemic. Given the pressure in such a situation, there is a risk that findings of early…

Applications · Statistics 2020-10-12 Sarah Friedrich , Tim Friede

A wide range of approaches have been applied to manage the spread of global pandemic events such as COVID-19, which have met with varying degrees of success. Given the large-scale social and economic impact coupled with the increasing time…

Computers and Society · Computer Science 2020-09-29 Rachit Agarwal , Abhik Banerjee

In this paper, we introduce a flexible and widely applicable nonparametric entropy-based testing procedure that can be used to assess the validity of simple hypotheses about a specific parametric population distribution. The testing…

Econometrics · Economics 2022-01-19 Ron Mittelhammer , George Judge , Miguel Henry

Coronavirus disease 2019 (COVID-19) is an ongoing pandemic infectious disease outbreak that has significantly harmed and threatened the health and lives of millions or even billions of people. COVID-19 has also negatively impacted the…

Quantitative Methods · Quantitative Biology 2020-04-14 Jirong Yi , Raghu Mudumbai , Weiyu Xu

Identification of defective members of large populations has been widely studied in the statistics community under the name of group testing. It involves grouping subsets of items into different pools and detecting defective members based…

Information Theory · Computer Science 2016-11-18 Mahdi Cheraghchi , Ali Hormati , Amin Karbasi , Martin Vetterli

As a consequence of missing data on tests for infection and imperfect accuracy of tests, reported rates of population infection by the SARS CoV-2 virus are lower than actual rates of infection. Hence, reported rates of severe illness…

Econometrics · Economics 2020-04-27 Charles F. Manski , Francesca Molinari

This paper presents methods to choose individuals to test for infection during a pandemic such as COVID-19, characterized by high contagion and presence of asymptomatic carriers. The smart-testing ideas presented here are motivated by…

Machine Learning · Computer Science 2020-12-29 Yingfei Wang , Inbal Yahav , Balaji Padmanabhan

In this paper, we develop an approach for the exact determination of the minimum sample size for estimating the parameter of an integer-valued random variable, which is parameterized by its expectation. Under some continuity and unimodal…

Statistics Theory · Mathematics 2012-11-20 Xinjia Chen , Zhengjia Chen

This paper utilizes the modified signed log-likelihood ratio method for the problem of inference about the common coefficient of variation in several independent normal populations. This method is applicable for both the problem of…

Computation · Statistics 2017-07-14 Mohmammad Reza Kazemi , Ali Akbar Jafari

Most of the common used models of epidemic spreading allow contaminating many neighbors of a particular node in the network. They are usually analyzed by differential equations on probability vectors. We propose a model of epidemic…

Physics and Society · Physics 2018-02-14 Wojciech Ganczarek