Related papers: Variable pool testing for infection spread estimat…
In this paper, we propose algorithms that leverage a known community structure to make group testing more efficient. We consider a population organized in disjoint communities: each individual participates in a community, and its infection…
Group testing is an efficient method for testing a large population to detect infected individuals. In this paper, we consider an efficient adaptive two stage group testing scheme. Using a straightforward analysis, we characterize the…
The group testing approach that achieves significant cost reduction over the individual testing approach has received a lot of interest lately for massive testing of COVID-19. Many studies simply assume samples mixed in a group are…
Pooling specimens, a well-accepted sampling strategy in biomedical research, can be applied to reduce the cost of studying biomarkers. Even if the cost of a single assay is not a major restriction in evaluating biomarkers, pooling can be a…
We develop a statistical model for the testing of disease prevalence in a population. The model assumes a binary test result, positive or negative, but allows for biases in sample selection and both type I (false positive) and type II…
We show that combining a prediction model (based on neural networks), with a new method of test pooling (better than the original Dorfman method, and better than double-pooling) called 'Grid', we can reduce the number of Covid-19 tests by…
This paper develops an agent-based disease spread model on a contact network in an effort to guide efforts at surveillance testing in small to moderate facilities such as nursing homes and meat-packing plants. The model employs Monte Carlo…
Group testing is utilized in the case when we want to find a few defectives among large amount of items. Testing n items one by one requires n tests, but if the ratio of defectives is small, group testing is an efficient way to reduce the…
In epidemic or pandemic situations, resources for testing the infection status of individuals may be scarce. Although group testing can help to significantly increase testing capabilities, the (repeated) testing of entire populations can…
Suppressing SARS-CoV-2 will likely require the rapid identification and isolation of infected individuals, on an ongoing basis. RT-PCR (reverse transcription polymerase chain reaction) tests are accurate but costly, making regular testing…
We consider real-time timely tracking of infection status (e.g., covid-19) of individuals in a population. In this work, a health care provider wants to detect infected people as well as people who have recovered from the disease as quickly…
In this paper, we propose algorithms that leverage a known community structure to make group testing more efficient. We consider a population organized in connected communities: each individual participates in one or more communities, and…
We propose `Tapestry', a novel approach to pooled testing with application to COVID-19 testing with quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) that can result in shorter testing time and conservation of reagents…
We present several related methods for creating confidence intervals to assess disease prevalence in variety of survey sampling settings. These include simple random samples with imperfect tests, weighted sampling with perfect tests, and…
This paper examines the statistical properties of a distributional form that arises from pooled testing for the prevalence of a binary outcome. Our base distribution is a two-parameter distribution using a prevalence and excess intensity…
We propose a new method to estimate the time-varying effective (or instantaneous) reproduction number of the novel coronavirus disease (COVID-19). The method is based on a discrete-time stochastic augmented compartmental model that…
Current pooling rules for multiply imputed data assume infinite populations. In some situations this assumption is not feasible as every unit in the population has been observed, potentially leading to over-covered population estimates. We…
Coronavirus case-count data has influenced government policies and drives most epidemiological forecasts. Limited testing is cited as the key driver behind minimal information on the COVID-19 pandemic. While expanded testing is laudable,…
Large-scale testing is considered key to assess the state of the current COVID-19 pandemic. Yet, the link between the reported case numbers and the true state of the pandemic remains elusive. We develop mathematical models based on…
We propose two-stage adaptive pooling schemes, 2-STAP and 2-STAMP, for detecting COVID-19 using real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) test kits. Similar to the Tapestry scheme of Ghosh et al., the…