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Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

T2 hyperintensities in spinal cord MR images are crucial biomarkers for conditions such as degenerative cervical myelopathy. However, current clinical diagnoses primarily rely on manual evaluation. Deep learning methods have shown promise…

Image and Video Processing · Electrical Eng. & Systems 2025-03-18 Qi Zhang , Xiuyuan Chen , Ziyi He , Kun Wang , Lianming Wu , Hongxing Shen , Jianqi Sun

The goal of unsupervised anomaly segmentation (UAS) is to detect the pixel-level anomalies unseen during training. It is a promising field in the medical imaging community, e.g, we can use the model trained with only healthy data to segment…

Image and Video Processing · Electrical Eng. & Systems 2021-03-17 Chenxin Li , Yunlong Zhang , Jiongcheng Li , Yue Huang , Xinghao Ding

Dealing with atypical traffic scenarios remains a challenging task in autonomous driving. However, most anomaly detection approaches cannot be trained on raw sensor data but require exposure to outlier data and powerful semantic…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Daniel Bogdoll , Noël Ollick , Tim Joseph , Svetlana Pavlitska , J. Marius Zöllner

Unsupervised Anomaly Detection (UAD) with incremental training is crucial in industrial manufacturing, as unpredictable defects make obtaining sufficient labeled data infeasible. However, continual learning methods primarily rely on…

Computer Vision and Pattern Recognition · Computer Science 2024-01-03 Jiaqi Liu , Kai Wu , Qiang Nie , Ying Chen , Bin-Bin Gao , Yong Liu , Jinbao Wang , Chengjie Wang , Feng Zheng

Early detection of anomalies in medical images such as brain MRI is highly relevant for diagnosis and treatment of many conditions. Supervised machine learning methods are limited to a small number of pathologies where there is good…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Alexander Frotscher , Jaivardhan Kapoor , Thomas Wolfers , Christian F. Baumgartner

Statistical analysis of magnetic resonance imaging (MRI) can help radiologists to detect pathologies that are otherwise likely to be missed. Deep learning (DL) has shown promise in modeling complex spatial data for brain anomaly detection.…

Computer Vision and Pattern Recognition · Computer Science 2020-11-26 Victor Saase , Holger Wenz , Thomas Ganslandt , Christoph Groden , Máté E. Maros

Brain pathologies can vary greatly in size and shape, ranging from few pixels (i.e. MS lesions) to large, space-occupying tumors. Recently proposed Autoencoder-based methods for unsupervised anomaly segmentation in brain MRI have shown…

Image and Video Processing · Electrical Eng. & Systems 2020-06-24 Christoph Baur , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab

Deep learning has demonstrated remarkable performance across various tasks in medical imaging. However, these approaches primarily focus on supervised learning, assuming that the training and testing data are drawn from the same…

Image and Video Processing · Electrical Eng. & Systems 2023-08-03 Suruchi Kumari , Pravendra Singh

Anomaly detection in medical imaging is to distinguish the relevant biomarkers of diseases from those of normal tissues. Deep supervised learning methods have shown potentials in various detection tasks, but its performances would be…

Image and Video Processing · Electrical Eng. & Systems 2021-12-01 Byungjai Kim , Kinam Kwon , Changheun Oh , Hyunwook Park

Unsupervised anomaly detection and segmentation methods train a model to learn the training distribution as `normal'. In the testing phase, they identify patterns that deviate from this normal distribution as `anomalies'. To learn the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Ziyun Liang , Xiaoqing Guo , Wentian Xu , Yasin Ibrahim , Natalie Voets , Pieter M Pretorius , J. Alison Noble , Konstantinos Kamnitsas

The core challenge in unsupervised anomaly detection is identifying abnormal patterns without prior knowledge of their characteristics. While existing methods have addressed aspects of this problem, they often struggle to learn a robust…

Machine Learning · Computer Science 2026-05-12 Prithul Sarker , Sushmita Sarker , Nicholas G. Murray , Alireza Tavakkoli

Diffusion magnetic resonance imaging (dMRI) is a crucial technique in neuroimaging studies, allowing for the non-invasive probing of the underlying structures of brain tissues. Clinical dMRI data is susceptible to various artifacts during…

Image and Video Processing · Electrical Eng. & Systems 2024-09-25 Sheng Chen , Zihao Tang , Xinyi Wang , Chenyu Wang , Weidong Cai

Deep anomaly detection models using a supervised mode of learning usually work under a closed set assumption and suffer from overfitting to previously seen rare anomalies at training, which hinders their applicability in a real scenario. In…

Image and Video Processing · Electrical Eng. & Systems 2020-10-26 Behzad Bozorgtabar , Dwarikanath Mahapatra , Guillaume Vray , Jean-Philippe Thiran

Unsupervised anomaly detection methods offer a promising and flexible alternative to supervised approaches, holding the potential to revolutionize medical scan analysis and enhance diagnostic performance. In the current landscape, it is…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Cosmin I. Bercea , Esther Puyol-Antón , Benedikt Wiestler , Daniel Rueckert , Julia A. Schnabel , Andrew P. King

Due to the diversity of brain anatomy and the scarcity of annotated data, supervised anomaly detection for brain MRI remains challenging, driving the development of unsupervised anomaly detection (UAD) approaches. Current UAD methods…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Hao Li , Zhenfeng Zhuang , Jingyu Lin , Yu Liu , Yifei Chen , Qiong Peng , Lequan Yu , Liansheng Wang

It can be challenging to identify brain MRI anomalies using supervised deep-learning techniques due to anatomical heterogeneity and the requirement for pixel-level labeling. Unsupervised anomaly detection approaches provide an alternative…

Image and Video Processing · Electrical Eng. & Systems 2023-08-30 Hasan Iqbal , Umar Khalid , Jing Hua , Chen Chen

Interpretation of medical images for diagnosis and treatment of complex disease from high-dimensional and heterogeneous data remains a key challenge in transforming healthcare. In the last few years, both supervised and unsupervised deep…

Image and Video Processing · Electrical Eng. & Systems 2018-12-20 Khalid Raza , Nripendra Kumar Singh

Unsupervised anomaly detection aims to detect defective parts of a sample by having access, during training, to a set of normal, i.e. defect-free, data. It has many applications in fields, such as industrial inspection or medical imaging,…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Robin Trombetta , Carole Lartizien

Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical image to detect outliers either in…

Computer Vision and Pattern Recognition · Computer Science 2020-10-13 Changhee Han , Leonardo Rundo , Kohei Murao , Tomoyuki Noguchi , Yuki Shimahara , Zoltan Adam Milacski , Saori Koshino , Evis Sala , Hideki Nakayama , Shinichi Satoh