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We propose a mathematical model based on probability theory to optimize COVID-19 testing by a multi-step batch testing approach with variable batch sizes. This model and simulation tool dramatically increase the efficiency and efficacy of…

Methodology · Statistics 2021-01-11 Hongshik Ahn , Haoran Jiang , Xiaolin Li

We propose two-stage adaptive pooling schemes, 2-STAP and 2-STAMP, for detecting COVID-19 using real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) test kits. Similar to the Tapestry scheme of Ghosh et al., the…

Information Theory · Computer Science 2020-07-07 Anoosheh Heidarzadeh , Krishna R. Narayanan

We develop a statistical model for the testing of disease prevalence in a population. The model assumes a binary test result, positive or negative, but allows for biases in sample selection and both type I (false positive) and type II…

Applications · Statistics 2021-12-28 Lucas Böttcher , Maria R. D'Orsogna , Tom Chou

Group testing can help maintain a widespread testing program using fewer resources amid a pandemic. In group testing, we are given $n$ samples, one per individual. These samples are arranged into $m < n$ pooled samples, where each pool is…

Information Theory · Computer Science 2022-01-20 Ritesh Goenka , Shu-Jie Cao , Chau-Wai Wong , Ajit Rajwade , Dror Baron

The group testing problem concerns discovering a small number of defective items within a large population by performing tests on pools of items. A test is positive if the pool contains at least one defective, and negative if it contains no…

Information Theory · Computer Science 2026-05-15 Matthew Aldridge , Oliver Johnson , Jonathan Scarlett

Just like your phone can detect what song is playing in crowded spaces, we show that Artificial Intelligence transfer learning algorithms trained on cough phone recordings results in diagnostic tests for COVID-19. To gain adoption by the…

We present a method for efficient estimation of the prevalence of infection in a population with high accuracy using only a small number of tests. The presented approach uses pool testing with a mix of pool sizes of various sizes. The test…

Applications · Statistics 2020-04-08 Itsik Bergel

The first part of the paper presents a review of the gold-standard testing protocol for Covid-19, real-time, reverse transcriptase PCR, and its properties and associated measurement data such as amplification curves that can guide the…

Quantitative Methods · Quantitative Biology 2021-06-08 Ryan Gabrys , Srilakshmi Pattabiraman , Vishal Rana , João Ribeiro , Mahdi Cheraghchi , Venkatesan Guruswami , Olgica Milenkovic

Diagnosis of COVID-19 at point of care is vital to the containment of the global pandemic. Point of care ultrasound (POCUS) provides rapid imagery of lungs to detect COVID-19 in patients in a repeatable and cost effective way. Previous work…

Image and Video Processing · Electrical Eng. & Systems 2020-12-03 Jay Roberts , Theodoros Tsiligkaridis

In comparison with individual testing, group testing (also known as pooled testing) is more efficient in reducing the number of tests and potentially leading to tremendous cost reduction. As indicated in the recent article posted on the US…

Populations and Evolution · Quantitative Biology 2021-06-16 Yi-Jheng Lin , Che-Hao Yu , Tzu-Hsuan Liu , Cheng-Shang Chang , Wen-Tsuen Chen

The CoVid-19 is spreading pandemically all over the world. A rapid defeat of the pandemic requires carrying out on the population a mass screening, able to separate positive from negative cases. Such a cleaning will free a flow of…

Populations and Evolution · Quantitative Biology 2020-03-27 Benjamin Isac Fargion , Daniele Fargion , Pier Giorgio De Sanctis Lucentini , Emanuele Habib

The COVID-19 is sweeping the world with deadly consequences. Its contagious nature and clinical similarity to other pneumonias make separating subjects contracted with COVID-19 and non-COVID-19 viral pneumonia a priority and a challenge.…

Machine Learning · Computer Science 2020-05-15 Forrest Sheng Bao , Youbiao He , Jie Liu , Yuanfang Chen , Qian Li , Christina R. Zhang , Lei Han , Baoli Zhu , Yaorong Ge , Shi Chen , Ming Xu , Liu Ouyang

In the break of COVID-19 pandemic, mass testing has become essential to reduce the spread of the virus. Several recent studies suggest that a significant number of COVID-19 patients display no physical symptoms whatsoever. Therefore, it is…

In the current COVID19 crisis many national healthcare systems are confronted with an acute shortage of tests for confirming SARS-CoV-2 infections. For low overall infection levels in the population, pooling of samples can drastically…

Populations and Evolution · Quantitative Biology 2020-03-24 Rudolf Hanel , Stefan Thurner

Group testing can help maintain a widespread testing program using fewer resources amid a pandemic. In a group testing setup, we are given n samples, one per individual. Each individual is either infected or uninfected. These samples are…

Signal Processing · Electrical Eng. & Systems 2023-07-19 Shu-Jie Cao , Ritesh Goenka , Chau-Wai Wong , Ajit Rajwade , Dror Baron

In group testing, the goal is to identify a subset of defective items within a larger set of items based on tests whose outcomes indicate whether at least one defective item is present. This problem is relevant in areas such as medical…

Information Theory · Computer Science 2022-10-24 Eric Price , Jonathan Scarlett , Nelvin Tan

The new coronavirus disease (COVID-19) has been declared a pandemic since March 2020 by the World Health Organization. It consists of an emerging viral infection with respiratory tropism that could develop atypical pneumonia. Experts…

Computer Vision and Pattern Recognition · Computer Science 2021-05-04 Walid Hariri , Ali Narin

We propose a novel testing and containment strategy in order to contain the spread of SARS-CoV2 while permitting large parts of the population to resume social and economic activity. Our approach recognises the fact that testing capacities…

Populations and Evolution · Quantitative Biology 2020-04-29 Jakob Jonnerby , Philip Lazos , Edwin Lock , Francisco Marmolejo-Cossío , C. Bronk Ramsey , Meghana Shukla , Divya Sridhar

The Reverse Transcription Polymerase Chain Reaction (RTPCR)} test is the silver bullet diagnostic test to discern COVID infection. Rapid antigen detection is a screening test to identify COVID positive patients in little as 15 minutes, but…

Machine Learning · Computer Science 2023-05-10 Md. Mohsin Sarker Raihan , Md. Mohi Uddin Khan , Laboni Akter , Abdullah Bin Shams

Estimating the prevalence of a disease is necessary for evaluating and mitigating risks of its transmission within or between populations. Estimates that consider how prevalence changes with time provide more information about these risks…

Applications · Statistics 2021-11-12 Braden Scherting , Alison Peel , Raina Plowright , Andrew Hoegh