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Ultametrics are an important class of distances used in applications such as phylogenetics, clustering and classification theory. Ultrametrics are essentially distances that can be represented by an edge-weighted rooted tree so that all of…

Combinatorics · Mathematics 2026-02-13 Katharina T. Huber , Vincent Moulton , Guillaume E. Scholz

Biological and physical systems often exhibit distinct structures at different spatial/temporal scales. Persistent homology is an algebraic tool that provides a mathematical framework for analyzing the multi-scale structures frequently…

Algebraic Topology · Mathematics 2016-02-01 Jonathan Jaquette , Miroslav Kramár

Construction of phylogenetic trees has traditionally focused on binary trees where all species appear on leaves, a problem for which numerous efficient solutions have been developed. Certain application domains though, such as viral…

Data Structures and Algorithms · Computer Science 2016-11-01 Dimitris Papamichail , Angela Huang , Andrew Miller , Edward Kennedy , Jan-Lucas Ott , Georgios Papamichail

In this paper we consider the problem of computing an mRNA sequence of maximal similarity for a given mRNA of secondary structure constraints, introduced by Backofen et al. in [BNS02] denoted as the MRSO problem. The problem is known to be…

Data Structures and Algorithms · Computer Science 2007-05-23 Frank Gurski

In the Properly Colored Spanning Tree problem, we are given an edge-colored undirected graph and the goal is to find a properly colored spanning tree, i.e., a spanning tree in which any two adjacent edges have distinct colors. The problem…

Data Structures and Algorithms · Computer Science 2024-02-02 Yuhang Bai , Kristóf Bérczi , Gergely Csáji , Tamás Schwarcz

The tree metric theorem provides a combinatorial four point condition that characterizes dissimilarity maps derived from pairwise compatible split systems. A similar (but weaker) four point condition characterizes dissimilarity maps derived…

Combinatorics · Mathematics 2011-10-24 Aaron Kleinman , Matan Harel , Lior Pachter

Comparing and computing distances between phylogenetic trees are important biological problems, especially for models where edge lengths play an important role. The geodesic distance measure between two phylogenetic trees with edge lengths…

Populations and Evolution · Quantitative Biology 2009-11-05 Megan Owen , J. Scott Provan

In this article we study the treewidth of the \emph{display graph}, an auxiliary graph structure obtained from the fusion of phylogenetic (i.e., evolutionary) trees at their leaves. Earlier work has shown that the treewidth of the display…

Discrete Mathematics · Computer Science 2017-04-03 Steven Kelk , Georgios Stamoulis , Taoyang Wu

Maximum bipartite matching is a fundamental algorithmic problem which can be solved in polynomial time. We consider a natural variant in which there is a separation constraint: the vertices on one side lie on a path or a grid, and two…

Data Structures and Algorithms · Computer Science 2023-03-20 Pasin Manurangsi , Erel Segal-Halevi , Warut Suksompong

Modelling the substitution of nucleotides along a phylogenetic tree is usually done by a hidden Markov process. This allows to define a distribution of characters at the leaves of the trees and one might be able to obtain polynomial…

Populations and Evolution · Quantitative Biology 2020-10-12 Marta Casanellas , Jesús Fernández-Sánchez , Marina Garrote-López

In this study, we investigate the problem of comparing gene trees reconciled with the same species tree using a novel semi-metric, called the Path-Label Reconciliation (PLR) dissimilarity measure. This approach not only quantifies…

A \emph{binary tanglegram} is a drawing of a pair of rooted binary trees whose leaf sets are in one-to-one correspondence; matching leaves are connected by inter-tree edges. For applications, for example, in phylogenetics, it is essential…

Computational Geometry · Computer Science 2010-09-17 Kevin Buchin , Maike Buchin , Jaroslaw Byrka , Martin Nöllenburg , Yoshio Okamoto , Rodrigo I. Silveira , Alexander Wolff

Optimal transport provides a metric which quantifies the dissimilarity between probability measures. For measures supported in discrete metric spaces, finding the optimal transport distance has cubic time complexity in the size of the…

Machine Learning · Computer Science 2024-01-30 Samantha Chen , Puoya Tabaghi , Yusu Wang

An evolutionary tree (phylogenetic tree) is a binary, rooted, unordered tree that models the evolutionary history of currently living species in which leaves are labeled by species. In this paper, we investigate the problem of finding the…

Populations and Evolution · Quantitative Biology 2013-04-02 Soheil Jahangiri Tazehkand , Seyed Naser Hashemi , Hadi Poormohammadi

We propose a statistical method to test whether two phylogenetic trees with given alignments are significantly incongruent. Our method compares the two distributions of phylogenetic trees given by the input alignments, instead of comparing…

Populations and Evolution · Quantitative Biology 2010-04-14 Elissaveta Arnaoudova , David Haws , Peter Huggins , Jerzy W. Jaromczyk , Neil Moore , Chris Schardl , Ruriko Yoshida

We study the problem of constructing phylogenetic trees for a given set of species. The problem is formulated as that of finding a minimum Steiner tree on $n$ points over the Boolean hypercube of dimension $d$. It is known that an optimal…

Data Structures and Algorithms · Computer Science 2012-06-18 Pranjal Awasthi , Avrim Blum , Jamie Morgenstern , Or Sheffet

In phylogenetic analysis, for non-molecular data, particularly morphology, parsimony optimization is the most commonly employed approach. In the past and present application of the parsimony principle, extra step numbers have been added…

Populations and Evolution · Quantitative Biology 2016-10-12 Yue Zhang

Dissimilarity measures for (possibly weighted) phylogenetic trees based on the comparison of their vectors of path lengths between pairs of taxa, have been present in the systematics literature since the early seventies. But, as far as…

Populations and Evolution · Quantitative Biology 2008-07-06 Gabriel Cardona , Merce Llabres , Francesc Rossello , Gabriel Valiente

The maximum agreement forest (MAF) problem in phylogenetics takes as input a set t >= 2 of binary phylogenetic trees T on the same set of taxa X. It asks for a partition of X into the smallest number of blocks such that the subtrees induced…

Combinatorics · Mathematics 2026-03-23 Steven Kelk , Ruben Meuwese , Leo van Iersel

The asymmetric tropical distance is a distance measure on the tropical torus $\mathbb{R}^n/\mathbb{R}\mathbf{1}$ and in particular on the Bergman fan $B(K_N) \subseteq \mathbb{R}^{\binom{N}{2}}/\mathbb{R}\mathbf{1}$ of the complete…

Combinatorics · Mathematics 2026-03-02 Fabian Lenzen , Lena Weis
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