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In this work we consider the image reconstruction problem of sparsely sampled dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). DCE-MRI is a technique for acquiring a series of MR images before, during and after intravenous…

Image and Video Processing · Electrical Eng. & Systems 2020-02-24 Kati Niinimäki , Matti Hanhela , Ville Kolehmainen

Image reconstruction in X-ray tomography is an ill-posed inverse problem, particularly with limited available data. Regularization is thus essential, but its effectiveness hinges on the choice of a regularization parameter that balances…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Chuyang Wu , Samuli Siltanen

Modern technologies are producing a wealth of data with complex structures. For instance, in two-dimensional digital imaging, flow cytometry, and electroencephalography, matrix type covariates frequently arise when measurements are obtained…

Methodology · Statistics 2013-10-22 Hua Zhou , Lexin Li

Compressed sensing (CS) methods in magnetic resonance imaging (MRI) offer rapid acquisition and improved image quality but require iterative reconstruction schemes with regularization to enforce sparsity. Regardless of the difficulty in…

Computer Vision and Pattern Recognition · Computer Science 2018-09-19 Raji Susan Mathew , Joseph Suresh Paul

Variational regularization of ill-posed inverse problems is based on minimizing the sum of a data fidelity term and a regularization term. The balance between them is tuned using a positive regularization parameter, whose automatic choice…

Numerical Analysis · Mathematics 2025-11-12 Markus Juvonen , Bjørn Jensen , Ilmari Pohjola , Yiqiu Dong , Samuli Siltanen

In this paper we propose a new approach for tomographic reconstruction with spatially varying regularization parameter. Our work is based on the SA-TV image restoration model proposed in [3] where an automated parameter selection rule for…

Numerical Analysis · Mathematics 2018-11-27 Yiqiu Dong , Carola-Bibiane Schönlieb

High-dimensional predictive models, those with more measurements than observations, require regularization to be well defined, perform well empirically, and possess theoretical guarantees. The amount of regularization, often determined by…

Methodology · Statistics 2019-07-16 Darren Homrighausen , Daniel J. McDonald

We propose a novel deformation corrected compressed sensing (DC-CS) framework to recover dynamic magnetic resonance images from undersampled measurements. We introduce a generalized formulation that is capable of handling a wide class of…

Computer Vision and Pattern Recognition · Computer Science 2014-09-04 Sajan Goud Lingala , Edward DiBella , Mathews Jacob

Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) ideally requires a high spatial and high temporal resolution, but hardware limitations prevent acquisitions from simultaneously achieving both. Existing image reconstruction…

Signal Processing · Electrical Eng. & Systems 2025-11-18 Alexander J. Mertens , Hai-Ling Margaret Cheng

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is used to study microvascular structure and tissue perfusion. In DCE-MRI a bolus of gadolinium based contrast agent is injected into the blood stream and spatiotemporal changes…

Medical Physics · Physics 2020-09-22 Matti Hanhela , Mikko Kettunen , Olli Gröhn , Marko Vauhkonen , Ville Kolehmainen

Measuring the dynamics and mechanical properties of muscles and joints is important to understand the (patho)physiology of muscles. However, acquiring dynamic time-resolved MRI data is challenging. We have previously developed…

The compressed sensing (CS) framework leverages the sparsity of MR images to reconstruct from undersampled acquisitions. CS reconstructions involve one or more regularization parameters that weigh sparsity in transform domains against…

X-ray tomography is a reliable tool for determining the inner structure of 3D object with penetrating X-rays. However, traditional reconstruction methods such as FDK require dense angular sampling in the data acquisition phase leading to…

A computational method is introduced for choosing the regularization parameter for total variation (TV) regularization. The approach is based on computing reconstructions at a few different resolutions and various values of regularization…

Kidney DCE-MRI aims at both qualitative assessment of kidney anatomy and quantitative assessment of kidney function by estimating the tracer kinetic (TK) model parameters. Accurate estimation of TK model parameters requires an accurate…

Machine Learning · Computer Science 2022-01-03 Aziz Koçanaoğulları , Cemre Ariyurek , Onur Afacan , Sila Kurugol

The choice of the parameter value for regularized inverse problems is critical to the results and remains a topic of interest. This article explores a criterion for selecting a good parameter value by maximizing the probability of the data,…

Numerical Analysis · Mathematics 2020-02-11 Toby Sanders , Rodrigo B. Platte , Robert D. Skeel

Compressed Sensing Magnetic Resonance Imaging (CS-MRI) significantly accelerates MR data acquisition at a sampling rate much lower than the Nyquist criterion. A major challenge for CS-MRI lies in solving the severely ill-posed inverse…

Image and Video Processing · Electrical Eng. & Systems 2019-10-30 Risheng Liu , Yuxi Zhang , Shichao Cheng , Zhongxuan Luo , Xin Fan

Purpose: To apply tracer kinetic models as temporal constraints during reconstruction of under-sampled dynamic contrast enhanced (DCE) MRI. Methods: A library of concentration v.s time profiles is simulated for a range of physiological…

Physics-inspired regularization is desired for intra-patient image registration since it can effectively capture the biomechanical characteristics of anatomical structures. However, a major challenge lies in the reliance on physical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Anna Reithmeir , Lina Felsner , Rickmer Braren , Julia A. Schnabel , Veronika A. Zimmer

The goal of dynamic magnetic resonance imaging (dynamic MRI) is to visualize tissue properties and their local changes over time that are traceable in the MR signal. We propose a new variational approach for the reconstruction of subsampled…

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