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Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Aim: provide a methodological framework for the process of clinical tests, clinical acceptance, and scientific assessment of algorithms and software based on the artificial intelligence (AI) technologies. Clinical tests are considered as a…

Early detection of skin cancers like melanoma is crucial to ensure high chances of survival for patients. Clinical application of Deep Learning (DL)-based Decision Support Systems (DSS) for skin cancer screening has the potential to improve…

Computer Vision and Pattern Recognition · Computer Science 2021-03-10 Adriano Lucieri , Andreas Dengel , Sheraz Ahmed

Medical image analysis has emerged as an essential element of contemporary healthcare, facilitating physicians in achieving expedited and precise diagnosis. Recent breakthroughs in deep learning, a subset of artificial intelligence, have…

Image and Video Processing · Electrical Eng. & Systems 2024-11-06 Aimina Ali Eli , Abida Ali

Model-Based Diagnosis deals with the identification of the real cause of a system's malfunction based on a formal system model and observations of the system behavior. When a malfunction is detected, there is usually not enough information…

Artificial Intelligence · Computer Science 2017-11-16 Patrick Rodler , Wolfgang Schmid , Konstantin Schekotihin

Purpose: To accelerate MRI acquisition by incorporating the previous scans of a subject during reconstruction. Although longitudinal imaging constitutes much of clinical MRI, leveraging previous scans is challenging due to the complex…

Image and Video Processing · Electrical Eng. & Systems 2025-10-21 Yonatan Urman , Zachary Shah , Ashwin Kumar , Bruno P. Soares , Kawin Setsompop

We introduce a novel class of factor analysis methodologies for the joint analysis of multiple studies. The goal is to separately identify and estimate 1) common factors shared across multiple studies, and 2) study-specific factors. We…

Applications · Statistics 2018-06-27 Roberta De Vito , Ruggero Bellio , Lorenzo Trippa , Giovanni Parmigiani

The COVID-19 pandemic has had a considerable impact on day-to-day life. Tackling the disease by providing the necessary resources to the affected is of paramount importance. However, estimation of the required resources is not a trivial…

Image and Video Processing · Electrical Eng. & Systems 2022-05-11 Sai Vidyaranya Nuthalapati , Marcela Vizcaychipi , Pallav Shah , Piotr Chudzik , Chee Hau Leow , Paria Yousefi , Ahmed Selim , Keiran Tait , Ben Irving

Deep learning has revolutionized many industries by enabling models to automatically learn complex patterns from raw data, reducing dependence on manual feature engineering. However, deep learning algorithms are sensitive to input data, and…

Machine Learning · Computer Science 2025-07-21 Mert Sehri , Zehui Hua , Francisco de Assis Boldt , Patrick Dumond

Cardiotoxicity induced by cancer treatment has become a major clinical concern, affecting the long-term survival and quality of life of cancer patients. Effective clinical decision-making, including the detection of cancer treatment-induced…

Human-Computer Interaction · Computer Science 2024-08-08 Siyi Wu , Weidan Cao , Shihan Fu , Bingsheng Yao , Ziqi Yang , Changchang Yin , Varun Mishra , Daniel Addison , Ping Zhang , Dakuo Wang

Advances in computing power, deep learning architectures, and expert labelled datasets have spurred the development of medical imaging artificial intelligence systems that rival clinical experts in a variety of scenarios. The National…

Image and Video Processing · Electrical Eng. & Systems 2021-11-18 Rohan Shad , John P. Cunningham , Euan A. Ashley , Curtis P. Langlotz , William Hiesinger

Would you trust physicians if they cannot explain their decisions to you? Medical diagnostics using machine learning gained enormously in importance within the last decade. However, without further enhancements many state-of-the-art machine…

Machine Learning · Computer Science 2022-06-01 Emanuel Slany , Yannik Ott , Stephan Scheele , Jan Paulus , Ute Schmid

Computerized adaptive tests (CATs) play a crucial role in educational assessment and diagnostic screening in behavioral health. Unlike traditional linear tests that administer a fixed set of pre-assembled items, CATs adaptively tailor the…

Methodology · Statistics 2026-05-11 Jiguang Li , Robert Gibbons , Veronika Rockova

The problem of learning the structure of a high dimensional graphical model from data has received considerable attention in recent years. In many applications such as sensor networks and proteomics it is often expensive to obtain samples…

Machine Learning · Statistics 2016-04-08 Gautam Dasarathy , Aarti Singh , Maria-Florina Balcan , Jong Hyuk Park

Analyzing microscopy images to extract biological object properties (e.g., their morphological organization, temporal dynamics, and population density) is fundamental to various biomedical research. Yet conducting this manually is costly…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Xiaofei Hui , Haoxuan Qu , Hossein Rahmani , Shuohong Wang , Jeff W. Lichtman , Jun Liu

The diagnosis of prostate cancer faces a problem with overdiagnosis that leads to damaging side effects due to unnecessary treatment. Research has shown that the use of multi-parametric magnetic resonance images to conduct biopsies can…

Image and Video Processing · Electrical Eng. & Systems 2021-06-04 Pedro C. Neto

This paper studies Clinical Intelligent Decision Support Systems (CIDSSs) for lung cancer segmentation, which are based on deep neural nets. A new interactive CIDSS is proposed and compared with previous approaches. Addition-ally, the…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Volodymyr Sydorskyi

Model informed precision dosing (MIPD) is a Bayesian framework to individualize drug therapy based on prior knowledge and patient-specific monitoring data. Typically, prior knowledge results from controlled clinical trials with a more…

Computation · Statistics 2025-05-27 Franziska Thoma , Niklas Hartung , Manfred Opper , Wilhelm Huisinga

The histological assessment of human tissue has emerged as the key challenge for detection and treatment of cancer. A plethora of different data sources ranging from tissue microarray data to gene expression, proteomics or metabolomics data…

Computer Vision and Pattern Recognition · Computer Science 2016-01-05 Thomas J. Fuchs , Joachim M. Buhmann

An integrated approach is proposed across visual and textual data to both determine and justify a medical diagnosis by a neural network. As deep learning techniques improve, interest grows to apply them in medical applications. To enable a…

Machine Learning · Computer Science 2019-07-15 Graham Spinks , Marie-Francine Moens