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Modern biomedical image analysis using deep learning often encounters the challenge of limited annotated data. To overcome this issue, deep generative models can be employed to synthesize realistic biomedical images. In this regard, we…

Image and Video Processing · Electrical Eng. & Systems 2026-02-23 Yuli Wu , Weidong He , Dennis Eschweiler , Ningxin Dou , Zixin Fan , Shengli Mi , Peter Walter , Johannes Stegmaier

The treatment of age-related macular degeneration (AMD) requires continuous eye exams using optical coherence tomography (OCT). The need for treatment is determined by the presence or change of disease-specific OCT-based biomarkers.…

Image and Video Processing · Electrical Eng. & Systems 2026-03-12 Timo Kepp , Helge Sudkamp , Claus von der Burchard , Hendrik Schenke , Peter Koch , Gereon Hüttmann , Johann Roider , Mattias P. Heinrich , Heinz Handels

Optical coherence tomography (OCT) is widely used for diagnosing and monitoring retinal diseases, such as age-related macular degeneration (AMD). The segmentation of biomarkers such as layers and lesions is essential for patient diagnosis…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Botond Fazekas , Guilherme Aresta , Philipp Seeböck , Julia Mai , Ursula Schmidt-Erfurth , Hrvoje Bogunović

Our objective is to evaluate the efficacy of methods that use deep learning (DL) for the automatic fine-grained segmentation of optical coherence tomography (OCT) images of the retina. OCT images from 10 patients with mild non-proliferative…

Computer Vision and Pattern Recognition · Computer Science 2018-01-31 Mike Pekala , Neil Joshi , David E. Freund , Neil M. Bressler , Delia Cabrera DeBuc , Philippe M Burlina

Optical coherence tomography (OCT) imaging is a well-known technology for visualizing retinal layers and helps ophthalmologists to detect possible diseases. Accurate and early diagnosis of common retinal diseases can prevent the patients…

Image and Video Processing · Electrical Eng. & Systems 2022-03-04 Mohammad Rahimzadeh , Mahmoud Reza Mohammadi

Retinal Vessel Segmentation is important for the diagnosis of various diseases. The research on retinal vessel segmentation focuses mainly on the improvement of the segmentation model which is usually based on U-Net architecture. In our…

Image and Video Processing · Electrical Eng. & Systems 2021-06-01 Enes Sadi Uysal , M. Şafak Bilici , B. Selin Zaza , M. Yiğit Özgenç , Onur Boyar

Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality that can acquire high-resolution volumes of the retinal vasculature and aid the diagnosis of ocular, neurological and cardiac diseases. Segmenting the…

With the introduction of spectral-domain optical coherence tomography (OCT), resulting in a significant increase in acquisition speed, the fast and accurate segmentation of 3-D OCT scans has become evermore important. This paper presents a…

Computer Vision and Pattern Recognition · Computer Science 2014-04-01 Fabian Rathke , Stefan Schmidt , Christoph Schnörr

Optical Coherence Tomography (OCT) is essential for diagnosing conditions such as glaucoma, diabetic retinopathy, and age-related macular degeneration. Accurate retinal layer segmentation enables quantitative biomarkers critical for…

Image and Video Processing · Electrical Eng. & Systems 2025-09-10 S M Asiful Islam Saky , Ugyen Tshering

Medical Image Segmentation is a useful application for medical image analysis including detecting diseases and abnormalities in imaging modalities such as MRI, CT etc. Deep learning has proven to be promising for this task but usually has a…

Image and Video Processing · Electrical Eng. & Systems 2023-02-08 Soham Bhosale , Arjun Krishna , Ge Wang , Klaus Mueller

Recent years have witnessed a growing academic and industrial interest in deep learning (DL) for medical imaging. To perform well, DL models require very large labeled datasets. However, most medical imaging datasets are small, with a…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Minh H. Vu , Lorenzo Tronchin , Tufve Nyholm , Tommy Löfstedt

Major retinal layer segmentation methods from OCT images assume that the retina is flattened in advance, and thus cannot always deal with retinas that have changes in retinal structure due to ophthalmopathy and/or curvature due to myopia.…

Image and Video Processing · Electrical Eng. & Systems 2024-10-03 Tsubasa Konno , Takahiro Ninomiya , Kanta Miura , Koichi Ito , Noriko Himori , Parmanand Sharma , Toru Nakazawa , Takafumi Aoki

This paper proposed a retinal image segmentation method based on conditional Generative Adversarial Network (cGAN) to segment optic disc. The proposed model consists of two successive networks: generator and discriminator. The generator…

Computer Vision and Pattern Recognition · Computer Science 2018-06-12 Vivek Kumar Singh , Hatem Rashwan , Farhan Akram , Nidhi Pandey , Md. Mostaf Kamal Sarker , Adel Saleh , Saddam Abdulwahab , Najlaa Maaroof , Santiago Romani , Domenec Puig

Optical coherence tomography (OCT) is one of the non-invasive and easy-to-acquire biomarkers (the thickness of the retinal layers, which is detectable within OCT scans) being investigated to diagnose Alzheimer's disease (AD). This work aims…

Image and Video Processing · Electrical Eng. & Systems 2022-06-14 Paria Jeihouni , Omid Dehzangi , Annahita Amireskandari , Ali Dabouei , Ali Rezai , Nasser M. Nasrabadi

Retinal optical coherence tomography (OCT) images provide crucial insights into the health of the posterior ocular segment. Therefore, the advancement of automated image analysis methods is imperative to equip clinicians and researchers…

Image and Video Processing · Electrical Eng. & Systems 2024-02-16 Jiahao Wang , Hong Peng , Shengchao Chen , Sufen Ren

In medical imaging, there are clinically relevant segmentation tasks where the output mask is a projection to a subset of input image dimensions. In this work, we propose a novel convolutional neural network architecture that can…

Image and Video Processing · Electrical Eng. & Systems 2021-08-03 Dmitrii Lachinov , Philipp Seeboeck , Julia Mai , Ursula Schmidt-Erfurth , Hrvoje Bogunovic

Purpose: To assess whether a generative adversarial network (GAN) could synthesize realistic optical coherence tomography (OCT) images that satisfactorily serve as the educational images for retinal specialists and the training datasets for…

Medical Physics · Physics 2020-06-02 Ce Zheng , Xiaolin Xie , Kang Zhou , Bang Chen , Jili Chen , Haiyun Ye , Wen Li , Tong Qiao , Shenghua Gao , Jianlong Yang , Jiang Liu

Optical coherence tomography (OCT) is a noninvasive imaging modality which can be used to obtain depth images of the retina. The changing layer thicknesses can thus be quantified by analyzing these OCT images, moreover these changes have…

Computer Vision and Pattern Recognition · Computer Science 2018-03-15 Yufan He , Aaron Carass , Bruno M. Jedynak , Sharon D. Solomon , Shiv Saidha , Peter A. Calabresi , Jerry L. Prince

We report, to our knowledge, the first end-to-end application of Generative Adversarial Networks (GANs) towards the synthesis of Optical Coherence Tomography (OCT) images of the retina. Generative models have gained recent attention for the…

Computer Vision and Pattern Recognition · Computer Science 2019-02-19 Stephen G. Odaibo , M. D. , M. S. , M. S.

Many eye diseases like Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD), and Glaucoma manifest in the retina, can cause irreversible blindness or severely impair the central version. The Optical Coherence Tomography…

Image and Video Processing · Electrical Eng. & Systems 2023-03-10 Nchongmaje Ndipenoch , Alina Miron , Zidong Wang , Yongmin Li