Related papers: Thermodynamic cost, speed, fluctuations, and error…
We review the trade-offs between speed, fluctuations, and thermodynamic cost involved with biological processes in nonequilibrium states, and discuss how optimal these processes are in light of the universal bound set by the thermodynamic…
Information processing at the molecular scale is limited by thermal fluctuations. This can cause undesired consequences in copying information since thermal noise can lead to errors that can compromise the functionality of the copy. For…
To mitigate errors induced by the cell's heterogeneous noisy environment, its main information channels and production networks utilize the kinetic proofreading (KPR) mechanism. Here, we examine two extensively-studied KPR circuits, DNA…
Thermodynamic uncertainty relations (TURs) are a set of inequalities expressing a fundamental trade-off between precision and dissipation in non-equilibrium classical and quantum thermodynamic processes. TURs show that achieving low…
Templated copying is the central operation by which biology produces complex molecules. Cells copy sequence information from DNA to RNA and on into proteins, which are the molecules responsible for the function and regulation of cellular…
Fluctuations affect the functionality of nanodevices. Thermodynamic uncertainty relations (TURs), derived within the framework of stochastic thermodynamics, show that a minimal amount of dissipation is required to obtain a given relative…
Many biological processes discriminate between correct and incorrect substrates through the kinetic proofreading mechanism which enables lower error at the cost of higher energy dissipation. Elucidating physicochemical constraints for…
Thermodynamic uncertainty relations (TURs) set fundamental bounds on the fluctuation and dissipation of stochastic systems. Here, we examine these bounds, in experiment and theory, by exploring the entire phase space of a cyclic information…
A cost-precision trade-off relationship, the so-called thermodynamic uncertainty relation (TUR), has been recently discovered in stochastic thermodynamics. It bounds certain thermodynamic observables in terms of the associated entropy…
Many versions of Thermodynamic Uncertainty Relations (TUR) have recently been discovered, which impose lower bounds on relative fluctuations of integrated currents in irreversible dissipative processes, and suggest that there may be…
The high accuracy exhibited by biological information transcription processes is due to kinetic proofreading, i.e., by a mechanism which reduces the error rate of the information-handling process by driving it out of equilibrium. We provide…
The thermodynamic uncertainty relation (TUR) provides a universal entropic bound for the precision of the fluctuation of the charge transfer for example for a class of continuous time stochastic processes. However, its extension to general…
Synthesis of biopolymers such as DNA, RNA, and proteins are biophysical processes aided by enzymes. Performance of these enzymes is usually characterized in terms of their average error rate and speed. However, because of thermal…
Thermodynamic cost of communication is a major factor in the thermodynamic cost of real-world computers, both biological and digital. Despite its importance, the fundamental principles underlying this cost remain poorly understood. This…
Thermodynamic uncertainty relations (TURs) relate precision to the dissipation rate, yet the inequalities can be far from saturation. Indeed, in catenane molecular motor simulations, we record precision far below the TUR limit. We further…
Thermodynamic uncertainty relations (TURs) place strict bounds on the fluctuations of thermodynamic quantities in terms of the associated entropy production. In this work we identify the tightest (and saturable) matrix-valued TUR that can…
Kinetic proofreading mechanisms explain the extraordinary accuracy observed in central biological events in terms of the enhanced specificity of substrate selection networks under a nonequilibrium environment. The nonequilibrium steady…
Conformational fluctuations are believed to play an important role in the process by which transcription factor proteins locate and bind their target site on the genome of a bacterium. Using a simple model, we show that the binding time can…
Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that,…
Feedback cooling enables a system to achieve low temperatures through measurement-based control. Determining the thermodynamic cost required to achieve the ideal cooling efficiency within a finite time remains an important problem. In this…